Amitriptyline Drug Interactions
320Total Interactions
20Severe
17Moderate
2Mild
| Drug | Severity | Summary |
|---|---|---|
| Adrenaline/epinephrine | SEVERE | Amitriptyline increases the effects of Adrenaline/epinephrine. Manufacturer advises avoid. |
| Bupropion | SEVERE | Bupropion is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor fo... |
| Cinacalcet | SEVERE | Cinacalcet is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor f... |
| Clozapine | SEVERE | Clozapine can cause constipation, as can Amitriptyline ; concurrent use might increase the risk o... |
| Dacomitinib | SEVERE | Dacomitinib is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor ... |
| Dronedarone | SEVERE | Dronedarone is predicted to increase the exposure to Amitriptyline. Manufacturer advises avoid. |
| Ephedrine | SEVERE | Amitriptyline is predicted to decrease the effects of Ephedrine. Manufacturer advises avoid. |
| Fluoxetine | SEVERE | Fluoxetine is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor f... |
| Fluvoxamine | SEVERE | Fluvoxamine increases the exposure to Amitriptyline. Manufacturer advises adjust dose. |
| Isocarboxazid | SEVERE | Amitriptyline is predicted to increase the risk of severe toxic reaction when given with Isocarbo... |
| Lithium | SEVERE | Amitriptyline potentially increases the risk of neurotoxicity when given with Lithium. Manufactur... |
| Moclobemide | SEVERE | Amitriptyline is predicted to increase the risk of severe toxic reaction when given with Moclobem... |
| Noradrenaline/norepinephrine | SEVERE | Amitriptyline increases the effects of Noradrenaline/norepinephrine. Manufacturer advises avoid. |
| Ozanimod | SEVERE | Amitriptyline might increase the risk of adverse effects when given with Ozanimod. Manufacturer m... |
| Paroxetine | SEVERE | Paroxetine is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor f... |
| Phenelzine | SEVERE | Amitriptyline is predicted to increase the risk of severe toxic reaction when given with Phenelzi... |
| Phenylephrine | SEVERE | Amitriptyline increases the effects of Phenylephrine. Manufacturer advises avoid. |
| Terbinafine | SEVERE | Terbinafine is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor ... |
| Tranylcypromine | SEVERE | Amitriptyline is predicted to increase the risk of severe toxic reaction when given with Tranylcy... |
| Vorasidenib | SEVERE | Vorasidenib might decrease the concentration of Amitriptyline. Manufacturer advises avoid. |
| Berotralstat | MODERATE | Berotralstat is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor... |
| Carbamazepine | MODERATE | Carbamazepine decreases the exposure to Amitriptyline. Manufacturer advises adjust dose. |
| Cimetidine | MODERATE | Cimetidine increases the exposure to Amitriptyline. Manufacturer makes no recommendation. |
| Clonidine | MODERATE | Amitriptyline decreases the antihypertensive effects of Clonidine. Manufacturer advises monitor a... |
| Darifenacin | MODERATE | Darifenacin (high-dose) is predicted to increase the exposure to Amitriptyline. Manufacturer advi... |
| Levodopa | MODERATE | Amitriptyline might decrease the absorption of Levodopa. Manufacturer makes no recommendation. |
| Methylphenidate | MODERATE | Methylphenidate might increase the concentration of Amitriptyline. Manufacturer advises use with ... |
| Metyrapone | MODERATE | Amitriptyline decreases the effects of Metyrapone. Manufacturer advises avoid. |
| Moxonidine | MODERATE | Amitriptyline is predicted to decrease the effects of Moxonidine. Manufacturer advises avoid. |
| Nirmatrelvir | MODERATE | Nirmatrelvir boosted with ritonavir is predicted to increase the concentration of Amitriptyline. ... |
| Phenobarbital | MODERATE | Phenobarbital is predicted to decrease the exposure to Amitriptyline. Manufacturer makes no recom... |
| Primidone | MODERATE | Primidone is predicted to decrease the exposure to Amitriptyline. Manufacturer makes no recommend... |
| Propafenone | MODERATE | Propafenone is predicted to increase the concentration of Amitriptyline. Manufacturer makes no re... |
| Ritonavir | MODERATE | Ritonavir is predicted to increase the exposure to Amitriptyline. Manufacturer advises monitor. |
| Sucralfate | MODERATE | Sucralfate is predicted to decrease the absorption of Amitriptyline. Manufacturer makes no recomm... |
| Thiopental | MODERATE | Amitriptyline increases the risk of cardiac arrhythmias and hypotension when given with Thiopenta... |
| Vasopressin | MODERATE | Amitriptyline might enhances the antidiuretic and hypertensive effects of Vasopressin. Manufactur... |
| Cobicistat | MILD | Cobicistat is predicted to slightly increase the exposure to Amitriptyline. Manufacturer makes no... |
| Pitolisant | MILD | Amitriptyline is predicted to decrease the efficacy of Pitolisant. Manufacturer makes no recommen... |
| Acebutolol | LOW | Both Amitriptyline and Acebutolol can increase the risk of hypotension. |
| Aceclofenac | LOW | Both Amitriptyline and Aceclofenac can increase the risk of hyponatraemia. |
| Aclidinium | LOW | Both Amitriptyline and Aclidinium can cause antimuscarinic effects. |
| Agomelatine | LOW | Both Amitriptyline and Agomelatine have effects on the CNS and can cause sedation, which might af... |
| Alcohol | LOW | Both Amitriptyline and Alcohol can increase the risk of hypotension. |
| Alfentanil | LOW | Both Amitriptyline and Alfentanil have effects on the CNS and can cause sedation, which might aff... |
| Alfuzosin | LOW | Both Amitriptyline and Alfuzosin can increase the risk of hypotension. |
| Alimemazine | LOW | Both Amitriptyline and Alimemazine have effects on the CNS and can cause sedation, which might af... |
| Aliskiren | LOW | Both Amitriptyline and Aliskiren can increase the risk of hypotension. |
| Alprazolam | LOW | Both Amitriptyline and Alprazolam have effects on the CNS and can cause sedation, which might aff... |
| Alprostadil | LOW | Both Amitriptyline and Alprostadil can increase the risk of hypotension. |
| Amantadine | LOW | Both Amitriptyline and Amantadine can increase the risk of hypotension. |
| Amiloride | LOW | Both Amitriptyline and Amiloride can increase the risk of hyponatraemia. |
| Amisulpride | LOW | Both Amitriptyline and Amisulpride can increase the risk of hyponatraemia. |
| Amlodipine | LOW | Both Amitriptyline and Amlodipine can increase the risk of hypotension. |
| Apomorphine | LOW | Both Amitriptyline and Apomorphine can increase the risk of hypotension. |
| Apraclonidine | LOW | Both Amitriptyline and Apraclonidine can increase the risk of hypotension. |
| Aripiprazole | LOW | Both Amitriptyline and Aripiprazole can increase the risk of hyponatraemia. |
| Asenapine | LOW | Both Amitriptyline and Asenapine can increase the risk of hyponatraemia. |
| Atenolol | LOW | Both Amitriptyline and Atenolol can increase the risk of hypotension. |
| Atropine | LOW | Both Amitriptyline and Atropine can cause antimuscarinic effects. |
| Avanafil | LOW | Both Amitriptyline and Avanafil can increase the risk of hypotension. |
| Azilsartan | LOW | Both Amitriptyline and Azilsartan can increase the risk of hypotension. |
| Baclofen | LOW | Both Amitriptyline and Baclofen can increase the risk of hypotension. |
| Bendroflumethiazide | LOW | Both Amitriptyline and Bendroflumethiazide can increase the risk of hyponatraemia. |
| Benperidol | LOW | Both Amitriptyline and Benperidol can increase the risk of hyponatraemia. |
| Betaxolol | LOW | Both Amitriptyline and Betaxolol can increase the risk of hypotension. |
| Bisoprolol | LOW | Both Amitriptyline and Bisoprolol can increase the risk of hypotension. |
| Bortezomib | LOW | Both Amitriptyline and Bortezomib can increase the risk of hypotension. |
| Brimonidine | LOW | Both Amitriptyline and Brimonidine can increase the risk of hypotension. |
| Bromocriptine | LOW | Both Amitriptyline and Bromocriptine can increase the risk of hypotension. |
| Buclizine | LOW | Both Amitriptyline and Buclizine have effects on the CNS and can cause sedation, which might affe... |
| Bumetanide | LOW | Both Amitriptyline and Bumetanide can increase the risk of hyponatraemia. |
| Buprenorphine | LOW | Both Amitriptyline and Buprenorphine have effects on the CNS and can cause sedation, which might ... |
| Cabergoline | LOW | Both Amitriptyline and Cabergoline can increase the risk of hypotension. |
| Canagliflozin | LOW | Both Amitriptyline and Canagliflozin can increase the risk of hypotension. |
| Candesartan | LOW | Both Amitriptyline and Candesartan can increase the risk of hypotension. |
| Cannabidiol | LOW | Both Amitriptyline and Cannabidiol have effects on the CNS and can cause sedation, which might af... |
| Captopril | LOW | Both Amitriptyline and Captopril can increase the risk of hypotension. |
| Carboplatin | LOW | Both Amitriptyline and Carboplatin can increase the risk of hyponatraemia. |
| Cariprazine | LOW | Both Amitriptyline and Cariprazine can increase the risk of hyponatraemia. |
| Carvedilol | LOW | Both Amitriptyline and Carvedilol can increase the risk of hypotension. |
| Celecoxib | LOW | Both Amitriptyline and Celecoxib can increase the risk of hyponatraemia. |
| Celiprolol | LOW | Both Amitriptyline and Celiprolol can increase the risk of hypotension. |
| Cenobamate | LOW | Both Amitriptyline and Cenobamate have effects on the CNS and can cause sedation, which might aff... |
| Chloral hydrate | LOW | Both Amitriptyline and Chloral hydrate have effects on the CNS and can cause sedation, which migh... |
| Chlordiazepoxide | LOW | Both Amitriptyline and Chlordiazepoxide have effects on the CNS and can cause sedation, which mig... |
| Chlorothiazide | LOW | Both Amitriptyline and Chlorothiazide can increase the risk of hyponatraemia. |
| Chlorphenamine | LOW | Both Amitriptyline and Chlorphenamine can cause antimuscarinic effects. |
| Chlorpromazine | LOW | Both Amitriptyline and Chlorpromazine can increase the risk of hyponatraemia. |
| Chlortalidone | LOW | Both Amitriptyline and Chlortalidone can increase the risk of hyponatraemia. |
| Cinnarizine | LOW | Both Amitriptyline and Cinnarizine have effects on the CNS and can cause sedation, which might af... |
| Cisplatin | LOW | Both Amitriptyline and Cisplatin can increase the risk of hyponatraemia. |
| Citalopram | LOW | Both Amitriptyline and Citalopram can increase the risk of hyponatraemia. |
| Clobazam | LOW | Both Amitriptyline and Clobazam have effects on the CNS and can cause sedation, which might affec... |
| Clomethiazole | LOW | Both Amitriptyline and Clomethiazole have effects on the CNS and can cause sedation, which might ... |
| Clonazepam | LOW | Both Amitriptyline and Clonazepam have effects on the CNS and can cause sedation, which might aff... |
| Codeine | LOW | Both Amitriptyline and Codeine have effects on the CNS and can cause sedation, which might affect... |
| Cyclizine | LOW | Both Amitriptyline and Cyclizine can cause antimuscarinic effects. |
| Cyclopentolate | LOW | Both Amitriptyline and Cyclopentolate can cause antimuscarinic effects. |
| Cyclophosphamide | LOW | Both Amitriptyline and Cyclophosphamide can increase the risk of hyponatraemia. |
| Cyproheptadine | LOW | Both Amitriptyline and Cyproheptadine can cause antimuscarinic effects. |
| Dapagliflozin | LOW | Both Amitriptyline and Dapagliflozin can increase the risk of hypotension. |
| Dapoxetine | LOW | Both Amitriptyline and Dapoxetine have effects on the CNS and can cause sedation, which might aff... |
| Daridorexant | LOW | Both Amitriptyline and Daridorexant have effects on the CNS and can cause sedation, which might a... |
| Desflurane | LOW | Both Amitriptyline and Desflurane can increase the risk of hypotension. |
| Desmopressin | LOW | Both Amitriptyline and Desmopressin can increase the risk of hyponatraemia. |
| Dexketoprofen | LOW | Both Amitriptyline and Dexketoprofen can increase the risk of hyponatraemia. |
| Dexmedetomidine | LOW | Both Amitriptyline and Dexmedetomidine have effects on the CNS and can cause sedation, which migh... |
| Diamorphine | LOW | Both Amitriptyline and Diamorphine have effects on the CNS and can cause sedation, which might af... |
| Diazepam | LOW | Both Amitriptyline and Diazepam have effects on the CNS and can cause sedation, which might affec... |
| Diazoxide | LOW | Both Amitriptyline and Diazoxide can increase the risk of hypotension. |
| Diclofenac | LOW | Both Amitriptyline and Diclofenac can increase the risk of hyponatraemia. |
| Dicycloverine | LOW | Both Amitriptyline and Dicycloverine can cause antimuscarinic effects. |
| Difelikefalin | LOW | Both Amitriptyline and Difelikefalin have effects on the CNS and can cause sedation, which might ... |
| Dihydrocodeine | LOW | Both Amitriptyline and Dihydrocodeine have effects on the CNS and can cause sedation, which might... |
| Diltiazem | LOW | Both Amitriptyline and Diltiazem can increase the risk of hypotension. |
| Dimenhydrinate | LOW | Both Amitriptyline and Dimenhydrinate can cause antimuscarinic effects. |
| Dipipanone | LOW | Both Amitriptyline and Dipipanone have effects on the CNS and can cause sedation, which might aff... |
| Dipyridamole | LOW | Both Amitriptyline and Dipyridamole can increase the risk of hypotension. |
| Disopyramide | LOW | Both Amitriptyline and Disopyramide can cause antimuscarinic effects. |
| Doxazosin | LOW | Both Amitriptyline and Doxazosin can increase the risk of hypotension. |
| Doxylamine | LOW | Both Amitriptyline and Doxylamine have effects on the CNS and can cause sedation, which might aff... |
| Dronabinol | LOW | Both Amitriptyline and Dronabinol have effects on the CNS and can cause sedation, which might aff... |
| Droperidol | LOW | Both Amitriptyline and Droperidol can increase the risk of hyponatraemia. |
| Duloxetine | LOW | Both Amitriptyline and Duloxetine can increase the risk of hyponatraemia. |
| Empagliflozin | LOW | Both Amitriptyline and Empagliflozin can increase the risk of hypotension. |
| Enalapril | LOW | Both Amitriptyline and Enalapril can increase the risk of hypotension. |
| Eplerenone | LOW | Both Amitriptyline and Eplerenone can increase the risk of hypotension. |
| Epoprostenol | LOW | Both Amitriptyline and Epoprostenol can increase the risk of hypotension. |
| Eprosartan | LOW | Both Amitriptyline and Eprosartan can increase the risk of hypotension. |
| Ertugliflozin | LOW | Both Amitriptyline and Ertugliflozin can increase the risk of hypotension. |
| Escitalopram | LOW | Both Amitriptyline and Escitalopram can increase the risk of hyponatraemia. |
| Esketamine | LOW | Both Amitriptyline and Esketamine can increase the risk of hypotension. |
| Eslicarbazepine | LOW | Both Amitriptyline and Eslicarbazepine can increase the risk of hyponatraemia. |
| Esmolol | LOW | Both Amitriptyline and Esmolol can increase the risk of hypotension. |
| Eszopiclone | LOW | Both Amitriptyline and Eszopiclone have effects on the CNS and can cause sedation, which might af... |
| Etodolac | LOW | Both Amitriptyline and Etodolac can increase the risk of hyponatraemia. |
| Etomidate | LOW | Both Amitriptyline and Etomidate can increase the risk of hypotension. |
| Etoricoxib | LOW | Both Amitriptyline and Etoricoxib can increase the risk of hyponatraemia. |
| Felodipine | LOW | Both Amitriptyline and Felodipine can increase the risk of hypotension. |
| Fentanyl | LOW | Both Amitriptyline and Fentanyl have effects on the CNS and can cause sedation, which might affec... |
| Fesoterodine | LOW | Both Amitriptyline and Fesoterodine can cause antimuscarinic effects. |
| Finerenone | LOW | Both Amitriptyline and Finerenone can increase the risk of hypotension. |
| Flavoxate | LOW | Both Amitriptyline and Flavoxate can cause antimuscarinic effects. |
| Flupentixol | LOW | Both Amitriptyline and Flupentixol can increase the risk of hyponatraemia. |
| Flurazepam | LOW | Both Amitriptyline and Flurazepam have effects on the CNS and can cause sedation, which might aff... |
| Flurbiprofen | LOW | Both Amitriptyline and Flurbiprofen can increase the risk of hyponatraemia. |
| Fosinopril | LOW | Both Amitriptyline and Fosinopril can increase the risk of hypotension. |
| Foslevodopa | LOW | Both Amitriptyline and Foslevodopa can increase the risk of hypotension. |
| Fosphenytoin | LOW | Both Amitriptyline and Fosphenytoin have effects on the CNS and can cause sedation, which might a... |
| Furosemide | LOW | Both Amitriptyline and Furosemide can increase the risk of hyponatraemia. |
| Gabapentin | LOW | Both Amitriptyline and Gabapentin have effects on the CNS and can cause sedation, which might aff... |
| Glyceryl trinitrate | LOW | Both Amitriptyline and Glyceryl trinitrate can increase the risk of hypotension. |
| Glycopyrronium | LOW | Both Amitriptyline and Glycopyrronium can cause antimuscarinic effects. |
| Guanfacine | LOW | Both Amitriptyline and Guanfacine can increase the risk of hypotension. |
| Haloperidol | LOW | Both Amitriptyline and Haloperidol can increase the risk of hyponatraemia. |
| Homatropine | LOW | Both Amitriptyline and Homatropine can cause antimuscarinic effects. |
| Hydralazine | LOW | Both Amitriptyline and Hydralazine can increase the risk of hypotension. |
| Hydrochlorothiazide | LOW | Both Amitriptyline and Hydrochlorothiazide can increase the risk of hyponatraemia. |
| Hydroflumethiazide | LOW | Both Amitriptyline and Hydroflumethiazide can increase the risk of hyponatraemia. |
| Hydromorphone | LOW | Both Amitriptyline and Hydromorphone have effects on the CNS and can cause sedation, which might ... |
| Hydroxyzine | LOW | Both Amitriptyline and Hydroxyzine can cause antimuscarinic effects. |
| Hyoscine | LOW | Both Amitriptyline and Hyoscine can cause antimuscarinic effects. |
| Ibuprofen | LOW | Both Amitriptyline and Ibuprofen can increase the risk of hyponatraemia. |
| Iloprost | LOW | Both Amitriptyline and Iloprost can increase the risk of hypotension. |
| Imidapril | LOW | Both Amitriptyline and Imidapril can increase the risk of hypotension. |
| Indapamide | LOW | Both Amitriptyline and Indapamide can increase the risk of hyponatraemia. |
| Indometacin | LOW | Both Amitriptyline and Indometacin can increase the risk of hyponatraemia. |
| Indoramin | LOW | Both Amitriptyline and Indoramin can increase the risk of hypotension. |
| Ipratropium | LOW | Both Amitriptyline and Ipratropium can cause antimuscarinic effects. |
| Irbesartan | LOW | Both Amitriptyline and Irbesartan can increase the risk of hypotension. |
| Isoflurane | LOW | Both Amitriptyline and Isoflurane can increase the risk of hypotension. |
| Isosorbide dinitrate | LOW | Both Amitriptyline and Isosorbide dinitrate can increase the risk of hypotension. |
| Isosorbide mononitrate | LOW | Both Amitriptyline and Isosorbide mononitrate can increase the risk of hypotension. |
| Ketamine | LOW | Both Amitriptyline and Ketamine can increase the risk of hypotension. |
| Ketoprofen | LOW | Both Amitriptyline and Ketoprofen can increase the risk of hyponatraemia. |
| Ketorolac | LOW | Both Amitriptyline and Ketorolac can increase the risk of hyponatraemia. |
| Ketotifen | LOW | Both Amitriptyline and Ketotifen have effects on the CNS and can cause sedation, which might affe... |
| Labetalol | LOW | Both Amitriptyline and Labetalol can increase the risk of hypotension. |
| Lacidipine | LOW | Both Amitriptyline and Lacidipine can increase the risk of hypotension. |
| Lamotrigine | LOW | Both Amitriptyline and Lamotrigine have effects on the CNS and can cause sedation, which might af... |
| Landiolol | LOW | Both Amitriptyline and Landiolol can increase the risk of hypotension. |
| Lercanidipine | LOW | Both Amitriptyline and Lercanidipine can increase the risk of hypotension. |
| Levetiracetam | LOW | Both Amitriptyline and Levetiracetam have effects on the CNS and can cause sedation, which might ... |
| Levobunolol | LOW | Both Amitriptyline and Levobunolol can increase the risk of hypotension. |
| Levomepromazine | LOW | Both Amitriptyline and Levomepromazine can increase the risk of hyponatraemia. |
| Lisinopril | LOW | Both Amitriptyline and Lisinopril can increase the risk of hypotension. |
| Lofexidine | LOW | Both Amitriptyline and Lofexidine can increase the risk of hypotension. |
| Loprazolam | LOW | Both Amitriptyline and Loprazolam have effects on the CNS and can cause sedation, which might aff... |
| Lorazepam | LOW | Both Amitriptyline and Lorazepam have effects on the CNS and can cause sedation, which might affe... |
| Lormetazepam | LOW | Both Amitriptyline and Lormetazepam have effects on the CNS and can cause sedation, which might a... |
| Losartan | LOW | Both Amitriptyline and Losartan can increase the risk of hypotension. |
| Loxapine | LOW | Both Amitriptyline and Loxapine can increase the risk of hyponatraemia. |
| Lurasidone | LOW | Both Amitriptyline and Lurasidone can increase the risk of hyponatraemia. |
| Mannitol | LOW | Both Amitriptyline and Mannitol can increase the risk of hyponatraemia. |
| Mefenamic acid | LOW | Both Amitriptyline and Mefenamic acid can increase the risk of hyponatraemia. |
| Melatonin | LOW | Both Amitriptyline and Melatonin have effects on the CNS and can cause sedation, which might affe... |
| Meloxicam | LOW | Both Amitriptyline and Meloxicam can increase the risk of hyponatraemia. |
| Meptazinol | LOW | Both Amitriptyline and Meptazinol have effects on the CNS and can cause sedation, which might aff... |
| Methadone | LOW | Both Amitriptyline and Methadone have effects on the CNS and can cause sedation, which might affe... |
| Methocarbamol | LOW | Both Amitriptyline and Methocarbamol have effects on the CNS and can cause sedation, which might ... |
| Methoxyflurane | LOW | Both Amitriptyline and Methoxyflurane can increase the risk of hypotension. |
| Methyldopa | LOW | Both Amitriptyline and Methyldopa can increase the risk of hypotension. |
| Metolazone | LOW | Both Amitriptyline and Metolazone can increase the risk of hyponatraemia. |
| Metoprolol | LOW | Both Amitriptyline and Metoprolol can increase the risk of hypotension. |
| Mianserin | LOW | Both Amitriptyline and Mianserin have effects on the CNS and can cause sedation, which might affe... |
| Midazolam | LOW | Both Amitriptyline and Midazolam have effects on the CNS and can cause sedation, which might affe... |
| Minoxidil | LOW | Both Amitriptyline and Minoxidil can increase the risk of hypotension. |
| Mirtazapine | LOW | Both Amitriptyline and Mirtazapine can increase the risk of hyponatraemia. |
| Morphine | LOW | Both Amitriptyline and Morphine have effects on the CNS and can cause sedation, which might affec... |
| Nabilone | LOW | Both Amitriptyline and Nabilone have effects on the CNS and can cause sedation, which might affec... |
| Nabumetone | LOW | Both Amitriptyline and Nabumetone can increase the risk of hyponatraemia. |
| Nadolol | LOW | Both Amitriptyline and Nadolol can increase the risk of hypotension. |
| Naproxen | LOW | Both Amitriptyline and Naproxen can increase the risk of hyponatraemia. |
| Nebivolol | LOW | Both Amitriptyline and Nebivolol can increase the risk of hypotension. |
| Nicardipine | LOW | Both Amitriptyline and Nicardipine can increase the risk of hypotension. |
| Nicorandil | LOW | Both Amitriptyline and Nicorandil can increase the risk of hypotension. |
| Nifedipine | LOW | Both Amitriptyline and Nifedipine can increase the risk of hypotension. |
| Nimodipine | LOW | Both Amitriptyline and Nimodipine can increase the risk of hypotension. |
| Nitrazepam | LOW | Both Amitriptyline and Nitrazepam have effects on the CNS and can cause sedation, which might aff... |
| Nitroprusside | LOW | Both Amitriptyline and Nitroprusside can increase the risk of hypotension. |
| Nitrous oxide | LOW | Both Amitriptyline and Nitrous oxide can increase the risk of hypotension. |
| Olanzapine | LOW | Both Amitriptyline and Olanzapine can increase the risk of hyponatraemia. |
| Olmesartan | LOW | Both Amitriptyline and Olmesartan can increase the risk of hypotension. |
| Orphenadrine | LOW | Both Amitriptyline and Orphenadrine can cause antimuscarinic effects. |
| Oxazepam | LOW | Both Amitriptyline and Oxazepam have effects on the CNS and can cause sedation, which might affec... |
| Oxcarbazepine | LOW | Both Amitriptyline and Oxcarbazepine can increase the risk of hyponatraemia. |
| Oxybutynin | LOW | Both Amitriptyline and Oxybutynin can cause antimuscarinic effects. |
| Oxycodone | LOW | Both Amitriptyline and Oxycodone have effects on the CNS and can cause sedation, which might affe... |
| Oxytocin | LOW | Both Amitriptyline and Oxytocin can increase the risk of hyponatraemia. |
| Paliperidone | LOW | Both Amitriptyline and Paliperidone can increase the risk of hyponatraemia. |
| Parecoxib | LOW | Both Amitriptyline and Parecoxib can increase the risk of hyponatraemia. |
| Pentazocine | LOW | Both Amitriptyline and Pentazocine have effects on the CNS and can cause sedation, which might af... |
| Perampanel | LOW | Both Amitriptyline and Perampanel have effects on the CNS and can cause sedation, which might aff... |
| Pericyazine | LOW | Both Amitriptyline and Pericyazine can increase the risk of hyponatraemia. |
| Perindopril | LOW | Both Amitriptyline and Perindopril can increase the risk of hypotension. |
| Pethidine | LOW | Both Amitriptyline and Pethidine have effects on the CNS and can cause sedation, which might affe... |
| Phenazone | LOW | Both Amitriptyline and Phenazone can increase the risk of hyponatraemia. |
| Phenytoin | LOW | Both Amitriptyline and Phenytoin have effects on the CNS and can cause sedation, which might affe... |
| Pimozide | LOW | Both Amitriptyline and Pimozide can increase the risk of hyponatraemia. |
| Pindolol | LOW | Both Amitriptyline and Pindolol can increase the risk of hypotension. |
| Piroxicam | LOW | Both Amitriptyline and Piroxicam can increase the risk of hyponatraemia. |
| Pizotifen | LOW | Both Amitriptyline and Pizotifen have effects on the CNS and can cause sedation, which might affe... |
| Pramipexole | LOW | Both Amitriptyline and Pramipexole can increase the risk of hypotension. |
| Prazosin | LOW | Both Amitriptyline and Prazosin can increase the risk of hypotension. |
| Pregabalin | LOW | Both Amitriptyline and Pregabalin have effects on the CNS and can cause sedation, which might aff... |
| Pridinol | LOW | Both Amitriptyline and Pridinol can cause antimuscarinic effects. |
| Prochlorperazine | LOW | Both Amitriptyline and Prochlorperazine can increase the risk of hyponatraemia. |
| Procyclidine | LOW | Both Amitriptyline and Procyclidine can cause antimuscarinic effects. |
| Promazine | LOW | Both Amitriptyline and Promazine can increase the risk of hyponatraemia. |
| Promethazine | LOW | Both Amitriptyline and Promethazine can cause antimuscarinic effects. |
| Propantheline | LOW | Both Amitriptyline and Propantheline can cause antimuscarinic effects. |
| Propiverine | LOW | Both Amitriptyline and Propiverine can cause antimuscarinic effects. |
| Propofol | LOW | Both Amitriptyline and Propofol can increase the risk of hypotension. |
| Propranolol | LOW | Both Amitriptyline and Propranolol can increase the risk of hypotension. |
| Quetiapine | LOW | Both Amitriptyline and Quetiapine can increase the risk of hyponatraemia. |
| Quinagolide | LOW | Both Amitriptyline and Quinagolide can increase the risk of hypotension. |
| Quinapril | LOW | Both Amitriptyline and Quinapril can increase the risk of hypotension. |
| Ramipril | LOW | Both Amitriptyline and Ramipril can increase the risk of hypotension. |
| Remifentanil | LOW | Both Amitriptyline and Remifentanil have effects on the CNS and can cause sedation, which might a... |
| Remimazolam | LOW | Both Amitriptyline and Remimazolam have effects on the CNS and can cause sedation, which might af... |
| Riociguat | LOW | Both Amitriptyline and Riociguat can increase the risk of hypotension. |
| Risperidone | LOW | Both Amitriptyline and Risperidone can increase the risk of hyponatraemia. |
| Ropinirole | LOW | Both Amitriptyline and Ropinirole can increase the risk of hypotension. |
| Rotigotine | LOW | Both Amitriptyline and Rotigotine can increase the risk of hypotension. |
| Rufinamide | LOW | Both Amitriptyline and Rufinamide have effects on the CNS and can cause sedation, which might aff... |
| Sacubitril | LOW | Both Amitriptyline and Sacubitril can increase the risk of hypotension. |
| Sapropterin | LOW | Both Amitriptyline and Sapropterin can increase the risk of hypotension. |
| Selegiline | LOW | Both Amitriptyline and Selegiline can increase the risk of hypotension. |
| Sertraline | LOW | Both Amitriptyline and Sertraline can increase the risk of hyponatraemia. |
| Sevoflurane | LOW | Both Amitriptyline and Sevoflurane can increase the risk of hypotension. |
| Sildenafil | LOW | Both Amitriptyline and Sildenafil can increase the risk of hypotension. |
| Sodium oxybate | LOW | Both Amitriptyline and Sodium oxybate can increase the risk of hypotension. |
| Solifenacin | LOW | Both Amitriptyline and Solifenacin can cause antimuscarinic effects. |
| Sotalol | LOW | Both Amitriptyline and Sotalol can increase the risk of hypotension. |
| Sparsentan | LOW | Both Amitriptyline and Sparsentan can increase the risk of hypotension. |
| Spironolactone | LOW | Both Amitriptyline and Spironolactone can increase the risk of hypotension. |
| Sufentanil | LOW | Both Amitriptyline and Sufentanil have effects on the CNS and can cause sedation, which might aff... |
| Sulindac | LOW | Both Amitriptyline and Sulindac can increase the risk of hyponatraemia. |
| Sulpiride | LOW | Both Amitriptyline and Sulpiride can increase the risk of hyponatraemia. |
| Tadalafil | LOW | Both Amitriptyline and Tadalafil can increase the risk of hypotension. |
| Tamsulosin | LOW | Both Amitriptyline and Tamsulosin can increase the risk of hypotension. |
| Tapentadol | LOW | Both Amitriptyline and Tapentadol have effects on the CNS and can cause sedation, which might aff... |
| Telmisartan | LOW | Both Amitriptyline and Telmisartan can increase the risk of hypotension. |
| Temazepam | LOW | Both Amitriptyline and Temazepam have effects on the CNS and can cause sedation, which might affe... |
| Tenoxicam | LOW | Both Amitriptyline and Tenoxicam can increase the risk of hyponatraemia. |
| Terazosin | LOW | Both Amitriptyline and Terazosin can increase the risk of hypotension. |
| Tetrabenazine | LOW | Both Amitriptyline and Tetrabenazine have effects on the CNS and can cause sedation, which might ... |
| Thalidomide | LOW | Both Amitriptyline and Thalidomide have effects on the CNS and can cause sedation, which might af... |
| Tiaprofenic acid | LOW | Both Amitriptyline and Tiaprofenic acid can increase the risk of hyponatraemia. |
| Timolol | LOW | Both Amitriptyline and Timolol can increase the risk of hypotension. |
| Tiotropium | LOW | Both Amitriptyline and Tiotropium can cause antimuscarinic effects. |
| Tizanidine | LOW | Both Amitriptyline and Tizanidine can increase the risk of hypotension. |
| Tolfenamic acid | LOW | Both Amitriptyline and Tolfenamic acid can increase the risk of hyponatraemia. |
| Tolterodine | LOW | Both Amitriptyline and Tolterodine can cause antimuscarinic effects. |
| Torasemide | LOW | Both Amitriptyline and Torasemide can increase the risk of hyponatraemia. |
| Tramadol | LOW | Both Amitriptyline and Tramadol can increase the risk of hyponatraemia. |
| Trandolapril | LOW | Both Amitriptyline and Trandolapril can increase the risk of hypotension. |
| Trazodone | LOW | Both Amitriptyline and Trazodone can increase the risk of hyponatraemia. |
| Treprostinil | LOW | Both Amitriptyline and Treprostinil can increase the risk of hypotension. |
| Trifluoperazine | LOW | Both Amitriptyline and Trifluoperazine can increase the risk of hyponatraemia. |
| Trihexyphenidyl | LOW | Both Amitriptyline and Trihexyphenidyl can cause antimuscarinic effects. |
| Tropicamide | LOW | Both Amitriptyline and Tropicamide can cause antimuscarinic effects. |
| Trospium | LOW | Both Amitriptyline and Trospium can cause antimuscarinic effects. |
| Umeclidinium | LOW | Both Amitriptyline and Umeclidinium can cause antimuscarinic effects. |
| Valproate | LOW | Both Amitriptyline and Valproate can increase the risk of hyponatraemia. |
| Valsartan | LOW | Both Amitriptyline and Valsartan can increase the risk of hypotension. |
| Vardenafil | LOW | Both Amitriptyline and Vardenafil can increase the risk of hypotension. |
| Venlafaxine | LOW | Both Amitriptyline and Venlafaxine can increase the risk of hyponatraemia. |
| Verapamil | LOW | Both Amitriptyline and Verapamil can increase the risk of hypotension. |
| Vericiguat | LOW | Both Amitriptyline and Vericiguat can increase the risk of hypotension. |
| Vernakalant | LOW | Both Amitriptyline and Vernakalant can increase the risk of hypotension. |
| Vigabatrin | LOW | Both Amitriptyline and Vigabatrin have effects on the CNS and can cause sedation, which might aff... |
| Vinblastine | LOW | Both Amitriptyline and Vinblastine can increase the risk of hyponatraemia. |
| Vincristine | LOW | Both Amitriptyline and Vincristine can increase the risk of hyponatraemia. |
| Vinorelbine | LOW | Both Amitriptyline and Vinorelbine can increase the risk of hyponatraemia. |
| Xipamide | LOW | Both Amitriptyline and Xipamide can increase the risk of hyponatraemia. |
| Zolpidem | LOW | Both Amitriptyline and Zolpidem have effects on the CNS and can cause sedation, which might affec... |
| Zopiclone | LOW | Both Amitriptyline and Zopiclone have effects on the CNS and can cause sedation, which might affe... |
| Zuclopenthixol | LOW | Both Amitriptyline and Zuclopenthixol can increase the risk of hyponatraemia. |
Check Amitriptyline against your patient's full medication list
InteractRx checks all drug combinations at once — built for GP surgery pharmacists.
Use the Free Checker