Codeine Drug Interactions
145Total Interactions
10Severe
8Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Buprenorphine | SEVERE | Buprenorphine is predicted to increase the risk of opiate withdrawal when given with Codeine. Man... |
| Clozapine | SEVERE | Clozapine can cause constipation, as can Codeine ; concurrent use might increase the risk of deve... |
| Isocarboxazid | SEVERE | Codeine is predicted to increase the risk of CNS excitation or depression when given with Isocarb... |
| Meptazinol | SEVERE | Meptazinol is predicted to increase the risk of opiate withdrawal when given with Codeine. Manufa... |
| Nalmefene | SEVERE | Nalmefene is predicted to decrease the efficacy of Codeine. Manufacturer advises avoid except in ... |
| Naltrexone | SEVERE | Naltrexone is predicted to decrease the efficacy of Codeine. Manufacturer advises avoid except in... |
| Ozanimod | SEVERE | Codeine might increase the risk of adverse effects when given with Ozanimod. Manufacturer makes n... |
| Pentazocine | SEVERE | Pentazocine is predicted to increase the risk of opiate withdrawal when given with Codeine. Manuf... |
| Phenelzine | SEVERE | Codeine is predicted to increase the risk of CNS excitation or depression when given with Phenelz... |
| Tranylcypromine | SEVERE | Codeine is predicted to increase the risk of CNS excitation or depression when given with Tranylc... |
| Bupropion | MODERATE | Bupropion is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Cinacalcet | MODERATE | Cinacalcet is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Dacomitinib | MODERATE | Dacomitinib is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Fluoxetine | MODERATE | Fluoxetine is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Mexiletine | MODERATE | Codeine potentially decreases the absorption of oral Mexiletine. Manufacturer makes no recommenda... |
| Paroxetine | MODERATE | Paroxetine is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Rifampicin | MODERATE | Rifampicin decreases the exposure to Codeine. Manufacturer makes no recommendation. |
| Terbinafine | MODERATE | Terbinafine is predicted to decrease the efficacy of Codeine. Manufacturer makes no recommendation. |
| Agomelatine | LOW | Both Codeine and Agomelatine have effects on the CNS and can cause sedation, which might affect t... |
| Alcohol | LOW | Both Codeine and Alcohol have effects on the CNS and can cause sedation, which might affect the a... |
| Alimemazine | LOW | Both Codeine and Alimemazine have effects on the CNS and can cause sedation, which might affect t... |
| Alprazolam | LOW | Both Codeine and Alprazolam have effects on the CNS and can cause sedation, which might affect th... |
| Amisulpride | LOW | Both Codeine and Amisulpride have effects on the CNS and can cause sedation, which might affect t... |
| Amitriptyline | LOW | Both Codeine and Amitriptyline have effects on the CNS and can cause sedation, which might affect... |
| Apomorphine | LOW | Both Codeine and Apomorphine have effects on the CNS and can cause sedation, which might affect t... |
| Apraclonidine | LOW | Both Codeine and Apraclonidine have effects on the CNS and can cause sedation, which might affect... |
| Aripiprazole | LOW | Both Codeine and Aripiprazole have effects on the CNS and can cause sedation, which might affect ... |
| Asenapine | LOW | Both Codeine and Asenapine have effects on the CNS and can cause sedation, which might affect the... |
| Baclofen | LOW | Both Codeine and Baclofen have effects on the CNS and can cause sedation, which might affect the ... |
| Benperidol | LOW | Both Codeine and Benperidol have effects on the CNS and can cause sedation, which might affect th... |
| Brimonidine | LOW | Both Codeine and Brimonidine have effects on the CNS and can cause sedation, which might affect t... |
| Bromocriptine | LOW | Both Codeine and Bromocriptine have effects on the CNS and can cause sedation, which might affect... |
| Buclizine | LOW | Both Codeine and Buclizine have effects on the CNS and can cause sedation, which might affect the... |
| Cabergoline | LOW | Both Codeine and Cabergoline have effects on the CNS and can cause sedation, which might affect t... |
| Cannabidiol | LOW | Both Codeine and Cannabidiol have effects on the CNS and can cause sedation, which might affect t... |
| Cariprazine | LOW | Both Codeine and Cariprazine have effects on the CNS and can cause sedation, which might affect t... |
| Cenobamate | LOW | Both Codeine and Cenobamate have effects on the CNS and can cause sedation, which might affect th... |
| Chloral hydrate | LOW | Both Codeine and Chloral hydrate have effects on the CNS and can cause sedation, which might affe... |
| Chlordiazepoxide | LOW | Both Codeine and Chlordiazepoxide have effects on the CNS and can cause sedation, which might aff... |
| Chlorphenamine | LOW | Both Codeine and Chlorphenamine have effects on the CNS and can cause sedation, which might affec... |
| Chlorpromazine | LOW | Both Codeine and Chlorpromazine have effects on the CNS and can cause sedation, which might affec... |
| Cinnarizine | LOW | Both Codeine and Cinnarizine have effects on the CNS and can cause sedation, which might affect t... |
| Citalopram | LOW | Both Codeine and Citalopram have effects on the CNS and can cause sedation, which might affect th... |
| Clobazam | LOW | Both Codeine and Clobazam have effects on the CNS and can cause sedation, which might affect the ... |
| Clomethiazole | LOW | Both Codeine and Clomethiazole have effects on the CNS and can cause sedation, which might affect... |
| Clomipramine | LOW | Both Codeine and Clomipramine have effects on the CNS and can cause sedation, which might affect ... |
| Clonazepam | LOW | Both Codeine and Clonazepam have effects on the CNS and can cause sedation, which might affect th... |
| Clonidine | LOW | Both Codeine and Clonidine have effects on the CNS and can cause sedation, which might affect the... |
| Cyclizine | LOW | Both Codeine and Cyclizine have effects on the CNS and can cause sedation, which might affect the... |
| Cyproheptadine | LOW | Both Codeine and Cyproheptadine have effects on the CNS and can cause sedation, which might affec... |
| Dapoxetine | LOW | Both Codeine and Dapoxetine have effects on the CNS and can cause sedation, which might affect th... |
| Daridorexant | LOW | Both Codeine and Daridorexant have effects on the CNS and can cause sedation, which might affect ... |
| Desflurane | LOW | Both Codeine and Desflurane have effects on the CNS and can cause sedation, which might affect th... |
| Dexmedetomidine | LOW | Both Codeine and Dexmedetomidine have effects on the CNS and can cause sedation, which might affe... |
| Diazepam | LOW | Both Codeine and Diazepam have effects on the CNS and can cause sedation, which might affect the ... |
| Difelikefalin | LOW | Both Codeine and Difelikefalin have effects on the CNS and can cause sedation, which might affect... |
| Dimenhydrinate | LOW | Both Codeine and Dimenhydrinate have effects on the CNS and can cause sedation, which might affec... |
| Dosulepin | LOW | Both Codeine and Dosulepin have effects on the CNS and can cause sedation, which might affect the... |
| Doxepin | LOW | Both Codeine and Doxepin have effects on the CNS and can cause sedation, which might affect the a... |
| Doxylamine | LOW | Both Codeine and Doxylamine have effects on the CNS and can cause sedation, which might affect th... |
| Dronabinol | LOW | Both Codeine and Dronabinol have effects on the CNS and can cause sedation, which might affect th... |
| Droperidol | LOW | Both Codeine and Droperidol have effects on the CNS and can cause sedation, which might affect th... |
| Duloxetine | LOW | Both Codeine and Duloxetine have effects on the CNS and can cause sedation, which might affect th... |
| Escitalopram | LOW | Both Codeine and Escitalopram have effects on the CNS and can cause sedation, which might affect ... |
| Esketamine | LOW | Both Codeine and Esketamine have effects on the CNS and can cause sedation, which might affect th... |
| Eszopiclone | LOW | Both Codeine and Eszopiclone have effects on the CNS and can cause sedation, which might affect t... |
| Etomidate | LOW | Both Codeine and Etomidate have effects on the CNS and can cause sedation, which might affect the... |
| Flupentixol | LOW | Both Codeine and Flupentixol have effects on the CNS and can cause sedation, which might affect t... |
| Flurazepam | LOW | Both Codeine and Flurazepam have effects on the CNS and can cause sedation, which might affect th... |
| Fluvoxamine | LOW | Both Codeine and Fluvoxamine have effects on the CNS and can cause sedation, which might affect t... |
| Foslevodopa | LOW | Both Codeine and Foslevodopa have effects on the CNS and can cause sedation, which might affect t... |
| Fosphenytoin | LOW | Both Codeine and Fosphenytoin have effects on the CNS and can cause sedation, which might affect ... |
| Gabapentin | LOW | Both Codeine and Gabapentin have effects on the CNS and can cause sedation, which might affect th... |
| Guanfacine | LOW | Both Codeine and Guanfacine have effects on the CNS and can cause sedation, which might affect th... |
| Haloperidol | LOW | Both Codeine and Haloperidol have effects on the CNS and can cause sedation, which might affect t... |
| Hydroxyzine | LOW | Both Codeine and Hydroxyzine have effects on the CNS and can cause sedation, which might affect t... |
| Imipramine | LOW | Both Codeine and Imipramine have effects on the CNS and can cause sedation, which might affect th... |
| Isoflurane | LOW | Both Codeine and Isoflurane have effects on the CNS and can cause sedation, which might affect th... |
| Ketamine | LOW | Both Codeine and Ketamine have effects on the CNS and can cause sedation, which might affect the ... |
| Ketotifen | LOW | Both Codeine and Ketotifen have effects on the CNS and can cause sedation, which might affect the... |
| Lamotrigine | LOW | Both Codeine and Lamotrigine have effects on the CNS and can cause sedation, which might affect t... |
| Levetiracetam | LOW | Both Codeine and Levetiracetam have effects on the CNS and can cause sedation, which might affect... |
| Levodopa | LOW | Both Codeine and Levodopa have effects on the CNS and can cause sedation, which might affect the ... |
| Levomepromazine | LOW | Both Codeine and Levomepromazine have effects on the CNS and can cause sedation, which might affe... |
| Lofepramine | LOW | Both Codeine and Lofepramine have effects on the CNS and can cause sedation, which might affect t... |
| Lofexidine | LOW | Both Codeine and Lofexidine have effects on the CNS and can cause sedation, which might affect th... |
| Loprazolam | LOW | Both Codeine and Loprazolam have effects on the CNS and can cause sedation, which might affect th... |
| Lorazepam | LOW | Both Codeine and Lorazepam have effects on the CNS and can cause sedation, which might affect the... |
| Lormetazepam | LOW | Both Codeine and Lormetazepam have effects on the CNS and can cause sedation, which might affect ... |
| Loxapine | LOW | Both Codeine and Loxapine have effects on the CNS and can cause sedation, which might affect the ... |
| Lurasidone | LOW | Both Codeine and Lurasidone have effects on the CNS and can cause sedation, which might affect th... |
| Melatonin | LOW | Both Codeine and Melatonin have effects on the CNS and can cause sedation, which might affect the... |
| Methocarbamol | LOW | Both Codeine and Methocarbamol have effects on the CNS and can cause sedation, which might affect... |
| Methoxyflurane | LOW | Both Codeine and Methoxyflurane have effects on the CNS and can cause sedation, which might affec... |
| Mianserin | LOW | Both Codeine and Mianserin have effects on the CNS and can cause sedation, which might affect the... |
| Midazolam | LOW | Both Codeine and Midazolam have effects on the CNS and can cause sedation, which might affect the... |
| Mirtazapine | LOW | Both Codeine and Mirtazapine have effects on the CNS and can cause sedation, which might affect t... |
| Moxonidine | LOW | Both Codeine and Moxonidine have effects on the CNS and can cause sedation, which might affect th... |
| Nabilone | LOW | Both Codeine and Nabilone have effects on the CNS and can cause sedation, which might affect the ... |
| Nitrazepam | LOW | Both Codeine and Nitrazepam have effects on the CNS and can cause sedation, which might affect th... |
| Nitrous oxide | LOW | Both Codeine and Nitrous oxide have effects on the CNS and can cause sedation, which might affect... |
| Nortriptyline | LOW | Both Codeine and Nortriptyline have effects on the CNS and can cause sedation, which might affect... |
| Olanzapine | LOW | Both Codeine and Olanzapine have effects on the CNS and can cause sedation, which might affect th... |
| Orphenadrine | LOW | Both Codeine and Orphenadrine have effects on the CNS and can cause sedation, which might affect ... |
| Oxazepam | LOW | Both Codeine and Oxazepam have effects on the CNS and can cause sedation, which might affect the ... |
| Paliperidone | LOW | Both Codeine and Paliperidone have effects on the CNS and can cause sedation, which might affect ... |
| Perampanel | LOW | Both Codeine and Perampanel have effects on the CNS and can cause sedation, which might affect th... |
| Pericyazine | LOW | Both Codeine and Pericyazine have effects on the CNS and can cause sedation, which might affect t... |
| Phenobarbital | LOW | Both Codeine and Phenobarbital have effects on the CNS and can cause sedation, which might affect... |
| Phenytoin | LOW | Both Codeine and Phenytoin have effects on the CNS and can cause sedation, which might affect the... |
| Pimozide | LOW | Both Codeine and Pimozide have effects on the CNS and can cause sedation, which might affect the ... |
| Pizotifen | LOW | Both Codeine and Pizotifen have effects on the CNS and can cause sedation, which might affect the... |
| Pramipexole | LOW | Both Codeine and Pramipexole have effects on the CNS and can cause sedation, which might affect t... |
| Pregabalin | LOW | Both Codeine and Pregabalin have effects on the CNS and can cause sedation, which might affect th... |
| Primidone | LOW | Both Codeine and Primidone have effects on the CNS and can cause sedation, which might affect the... |
| Prochlorperazine | LOW | Both Codeine and Prochlorperazine have effects on the CNS and can cause sedation, which might aff... |
| Procyclidine | LOW | Both Codeine and Procyclidine have effects on the CNS and can cause sedation, which might affect ... |
| Promazine | LOW | Both Codeine and Promazine have effects on the CNS and can cause sedation, which might affect the... |
| Promethazine | LOW | Both Codeine and Promethazine have effects on the CNS and can cause sedation, which might affect ... |
| Propofol | LOW | Both Codeine and Propofol have effects on the CNS and can cause sedation, which might affect the ... |
| Quetiapine | LOW | Both Codeine and Quetiapine have effects on the CNS and can cause sedation, which might affect th... |
| Quinagolide | LOW | Both Codeine and Quinagolide have effects on the CNS and can cause sedation, which might affect t... |
| Remimazolam | LOW | Both Codeine and Remimazolam have effects on the CNS and can cause sedation, which might affect t... |
| Risperidone | LOW | Both Codeine and Risperidone have effects on the CNS and can cause sedation, which might affect t... |
| Ropinirole | LOW | Both Codeine and Ropinirole have effects on the CNS and can cause sedation, which might affect th... |
| Rotigotine | LOW | Both Codeine and Rotigotine have effects on the CNS and can cause sedation, which might affect th... |
| Rufinamide | LOW | Both Codeine and Rufinamide have effects on the CNS and can cause sedation, which might affect th... |
| Sertraline | LOW | Both Codeine and Sertraline have effects on the CNS and can cause sedation, which might affect th... |
| Sevoflurane | LOW | Both Codeine and Sevoflurane have effects on the CNS and can cause sedation, which might affect t... |
| Sodium oxybate | LOW | Both Codeine and Sodium oxybate have effects on the CNS and can cause sedation, which might affec... |
| Sulpiride | LOW | Both Codeine and Sulpiride have effects on the CNS and can cause sedation, which might affect the... |
| Temazepam | LOW | Both Codeine and Temazepam have effects on the CNS and can cause sedation, which might affect the... |
| Tetrabenazine | LOW | Both Codeine and Tetrabenazine have effects on the CNS and can cause sedation, which might affect... |
| Thalidomide | LOW | Both Codeine and Thalidomide have effects on the CNS and can cause sedation, which might affect t... |
| Thiopental | LOW | Both Codeine and Thiopental have effects on the CNS and can cause sedation, which might affect th... |
| Tizanidine | LOW | Both Codeine and Tizanidine have effects on the CNS and can cause sedation, which might affect th... |
| Trazodone | LOW | Both Codeine and Trazodone have effects on the CNS and can cause sedation, which might affect the... |
| Trifluoperazine | LOW | Both Codeine and Trifluoperazine have effects on the CNS and can cause sedation, which might affe... |
| Trihexyphenidyl | LOW | Both Codeine and Trihexyphenidyl have effects on the CNS and can cause sedation, which might affe... |
| Trimipramine | LOW | Both Codeine and Trimipramine have effects on the CNS and can cause sedation, which might affect ... |
| Venlafaxine | LOW | Both Codeine and Venlafaxine have effects on the CNS and can cause sedation, which might affect t... |
| Vigabatrin | LOW | Both Codeine and Vigabatrin have effects on the CNS and can cause sedation, which might affect th... |
| Zolpidem | LOW | Both Codeine and Zolpidem have effects on the CNS and can cause sedation, which might affect the ... |
| Zopiclone | LOW | Both Codeine and Zopiclone have effects on the CNS and can cause sedation, which might affect the... |
| Zuclopenthixol | LOW | Both Codeine and Zuclopenthixol have effects on the CNS and can cause sedation, which might affec... |
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