Digoxin Drug Interactions
186Total Interactions
77Severe
61Moderate
4Mild
| Drug | Severity | Summary |
|---|---|---|
| Alfacalcidol | SEVERE | Alfacalcidol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer ... |
| Aminophylline | SEVERE | Aminophylline is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Amiodarone | SEVERE | Amiodarone is predicted to moderately increase the exposure to Digoxin. Manufacturer advises moni... |
| Amphotericin B | SEVERE | Amphotericin B is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Man... |
| Asciminib | SEVERE | Asciminib is predicted to increase the exposure to Digoxin. Manufacturer makes no recommendation. |
| Azithromycin | SEVERE | Azithromycin increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concent... |
| Beclometasone | SEVERE | Beclometasone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Bendroflumethiazide | SEVERE | Bendroflumethiazide is predicted to increase the risk of Digoxin toxicity when given with Digoxin... |
| Betamethasone | SEVERE | Betamethasone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Budesonide | SEVERE | Budesonide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Bumetanide | SEVERE | Bumetanide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Bupropion | SEVERE | Bupropion might decrease the exposure to Digoxin. Manufacturer advises monitor. |
| Calcifediol | SEVERE | Calcifediol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer a... |
| Calcipotriol | SEVERE | Calcipotriol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer ... |
| Calcitriol | SEVERE | Calcitriol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer ad... |
| Ceritinib | SEVERE | Ceritinib is predicted to increase the risk of bradycardia when given with Digoxin. Manufacturer ... |
| Chlorothiazide | SEVERE | Chlorothiazide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Man... |
| Chlortalidone | SEVERE | Chlortalidone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Ciclesonide | SEVERE | Ciclesonide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufa... |
| Ciclosporin | SEVERE | Ciclosporin increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Clarithromycin | SEVERE | Clarithromycin increases the concentration of Digoxin. Manufacturer advises monitor Digoxin conce... |
| Colecalciferol | SEVERE | Colecalciferol is predicted to increase the risk of toxicity when given with Digoxin. Manufacture... |
| Deflazacort | SEVERE | Deflazacort is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufa... |
| Dexamethasone | SEVERE | Dexamethasone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Diltiazem | SEVERE | Diltiazem increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Dronedarone | SEVERE | Dronedarone is predicted to moderately increase the exposure to Digoxin. Manufacturer advises mon... |
| Ergocalciferol | SEVERE | Ergocalciferol is predicted to increase the risk of toxicity when given with Digoxin. Manufacture... |
| Erythromycin | SEVERE | Erythromycin increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concent... |
| Fludrocortisone | SEVERE | Fludrocortisone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Ma... |
| Fluticasone | SEVERE | Fluticasone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufa... |
| Formoterol | SEVERE | Formoterol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Furosemide | SEVERE | Furosemide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Hydrochlorothiazide | SEVERE | Hydrochlorothiazide is predicted to increase the risk of Digoxin toxicity when given with Digoxin... |
| Hydrocortisone | SEVERE | Hydrocortisone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Man... |
| Hydroflumethiazide | SEVERE | Hydroflumethiazide is predicted to increase the risk of Digoxin toxicity when given with Digoxin.... |
| Indacaterol | SEVERE | Indacaterol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufa... |
| Indapamide | SEVERE | Indapamide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Indometacin | SEVERE | Indometacin increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concentr... |
| Isoprenaline | SEVERE | Isoprenaline is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manuf... |
| Itraconazole | SEVERE | Itraconazole increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Ketoconazole | SEVERE | Ketoconazole is predicted to increase the exposure to Digoxin. Manufacturer advises monitor Digox... |
| Lopinavir | SEVERE | Lopinavir boosted with ritonavir is predicted to increase the exposure to Digoxin. Manufacturer a... |
| Mefloquine | SEVERE | Mefloquine is predicted to increase the risk of bradycardia when given with Digoxin. Manufacturer... |
| Methylprednisolone | SEVERE | Methylprednisolone is predicted to increase the risk of Digoxin toxicity when given with Digoxin.... |
| Metolazone | SEVERE | Metolazone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Mirabegron | SEVERE | Mirabegron slightly increases the exposure to Digoxin. Manufacturer advises monitor concentration... |
| Mometasone | SEVERE | Mometasone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Nirmatrelvir | SEVERE | Nirmatrelvir boosted with ritonavir is predicted to increase the concentration of Digoxin. Manufa... |
| Olodaterol | SEVERE | Olodaterol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Pancuronium | SEVERE | Pancuronium is predicted to increase the risk of cardiovascular adverse effects when given with D... |
| Paricalcitol | SEVERE | Paricalcitol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer ... |
| Penicillamine | SEVERE | Penicillamine potentially decreases the concentration of Digoxin. Manufacturer advises separate a... |
| Posaconazole | SEVERE | Posaconazole is predicted to increase the concentration of Digoxin. Manufacturer advises monitor ... |
| Prednisolone | SEVERE | Prednisolone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manuf... |
| Propafenone | SEVERE | Propafenone increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Quinine | SEVERE | Quinine increases the concentration of Digoxin. Manufacturer advises monitor and adjust Digoxin d... |
| Ritonavir | SEVERE | Ritonavir increases the concentration of Digoxin. Manufacturer advises adjust dose and monitor co... |
| Salbutamol | SEVERE | Salbutamol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Salmeterol | SEVERE | Salmeterol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Sparsentan | SEVERE | Sparsentan is predicted to increase the exposure to Digoxin. Manufacturer makes no recommendation. |
| St John's wort | SEVERE | St John's wort decreases the concentration of Digoxin. Manufacturer advises avoid. |
| Sucralfate | SEVERE | Sucralfate decreases the absorption of Digoxin. Manufacturer advises separate administration by 2... |
| Suxamethonium | SEVERE | Suxamethonium is predicted to increase the risk of cardiovascular adverse effects when given with... |
| Tacalcitol | SEVERE | Tacalcitol is predicted to increase the risk of toxicity when given with Digoxin. Manufacturer ad... |
| Tepotinib | SEVERE | Tepotinib is predicted to increase the concentration of Digoxin. Manufacturer advises monitor. |
| Terbutaline | SEVERE | Terbutaline is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufa... |
| Theophylline | SEVERE | Theophylline is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manuf... |
| Torasemide | SEVERE | Torasemide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Triamcinolone | SEVERE | Triamcinolone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manu... |
| Vamorolone | SEVERE | Vamorolone is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Velpatasvir | SEVERE | Velpatasvir is predicted to increase the exposure to Digoxin. Manufacturer advises monitor. |
| Vemurafenib | SEVERE | Vemurafenib slightly increases the exposure to Digoxin. Manufacturer advises use with caution and... |
| Venetoclax | SEVERE | Venetoclax increases the exposure to Digoxin. Manufacturer advises avoid or adjust dose. |
| Verapamil | SEVERE | Verapamil increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Vilanterol | SEVERE | Vilanterol is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufac... |
| Voxilaprevir | SEVERE | Voxilaprevir with sofosbuvir and velpatasvir is predicted to increase the exposure to Digoxin. Ma... |
| Xipamide | SEVERE | Xipamide is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manufactu... |
| Abrocitinib | MODERATE | Abrocitinib might increase the exposure to Digoxin. Manufacturer advises caution. |
| Acarbose | MODERATE | Acarbose decreases the concentration of Digoxin. Manufacturer advises monitor. |
| Amikacin | MODERATE | Amikacin might increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Balsalazide | MODERATE | Balsalazide is predicted to decrease the concentration of Digoxin. Manufacturer advises monitor. |
| Belumosudil | MODERATE | Belumosudil might increase the exposure to Digoxin. Manufacturer advises avoid or adjust dose. |
| Berotralstat | MODERATE | Berotralstat is predicted to increase the concentration of Digoxin. Manufacturer advises monitor ... |
| Calcium acetate | MODERATE | intravenous Calcium acetate increases the effects of Digoxin. Manufacturer advises avoid. |
| Calcium carbonate | MODERATE | intravenous Calcium carbonate increases the effects of Digoxin. Manufacturer advises avoid. |
| Calcium chloride | MODERATE | intravenous Calcium chloride increases the effects of Digoxin. Manufacturer advises avoid. |
| Calcium gluconate | MODERATE | intravenous Calcium gluconate increases the effects of Digoxin. Manufacturer advises avoid. |
| Calcium lactate | MODERATE | intravenous Calcium lactate increases the effects of Digoxin. Manufacturer advises avoid. |
| Calcium phosphate | MODERATE | intravenous Calcium phosphate increases the effects of Digoxin. Manufacturer advises avoid. |
| Cannabidiol | MODERATE | Cannabidiol is predicted to increase the exposure to Digoxin. Manufacturer advises monitor and ad... |
| Carbimazole | MODERATE | Carbimazole affects the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Dabrafenib | MODERATE | Dabrafenib is predicted to decrease the exposure to Digoxin. Manufacturer advises monitor. |
| Danicopan | MODERATE | Danicopan is predicted to increase the exposure to Digoxin. Manufacturer advises caution. |
| Daridorexant | MODERATE | Daridorexant is predicted to increase the exposure to Digoxin. Manufacturer advises caution. |
| Deutivacaftor | MODERATE | Deutivacaftor is predicted to increase the exposure to Digoxin. Manufacturer advises caution. |
| Eliglustat | MODERATE | Eliglustat increases the exposure to Digoxin. Manufacturer advises adjust dose. |
| Enzalutamide | MODERATE | Enzalutamide is predicted to increase the exposure to Digoxin. Manufacturer advises use with caut... |
| Erdafitinib | MODERATE | Erdafitinib is predicted to increase the exposure to Digoxin. Manufacturer advises separate admin... |
| Fosphenytoin | MODERATE | Fosphenytoin is predicted to decrease the concentration of Digoxin. Manufacturer makes no recomme... |
| Gentamicin | MODERATE | Gentamicin might increases the concentration of Digoxin. Manufacturer advises monitor and adjust ... |
| Glecaprevir | MODERATE | Glecaprevir with pibrentasvir increases the exposure to Digoxin. Manufacturer advises caution and... |
| Ibrutinib | MODERATE | Ibrutinib might increase the exposure to Digoxin. Manufacturer advises separate administration by... |
| Isavuconazole | MODERATE | Isavuconazole slightly increases the exposure to Digoxin. Manufacturer advises monitor and adjust... |
| Ivacaftor | MODERATE | Ivacaftor slightly increases the exposure to Digoxin. Manufacturer advises caution. |
| Ivosidenib | MODERATE | Ivosidenib is predicted to alter the exposure to Digoxin. Manufacturer makes no recommendation. |
| Lapatinib | MODERATE | Lapatinib slightly increases the exposure to Digoxin. Manufacturer advises caution. |
| Ledipasvir | MODERATE | Ledipasvir is predicted to increase the exposure to Digoxin. Manufacturer advises monitor and adj... |
| Lenacapavir | MODERATE | Lenacapavir is predicted to increase the concentration of Digoxin. Manufacturer advises caution o... |
| Levothyroxine | MODERATE | Levothyroxine is predicted to affect the concentration of Digoxin. Manufacturer advises monitor a... |
| Liothyronine | MODERATE | Liothyronine is predicted to affect the concentration of Digoxin. Manufacturer advises monitor an... |
| Lomitapide | MODERATE | Lomitapide might increase the exposure to Digoxin. Manufacturer advises adjust dose. |
| Lorlatinib | MODERATE | Lorlatinib is predicted to decrease the exposure to Digoxin. Manufacturer advises caution. |
| Maribavir | MODERATE | Maribavir very slightly increases the exposure to Digoxin. Manufacturer advises monitor and adjus... |
| Neomycin | MODERATE | Neomycin decreases the concentration of Digoxin. Manufacturer makes no recommendation. |
| Neratinib | MODERATE | Neratinib slightly increases the exposure to Digoxin. Manufacturer advises monitor. |
| Netilmicin | MODERATE | Netilmicin might increases the concentration of Digoxin. Manufacturer advises monitor and adjust ... |
| Olaparib | MODERATE | Olaparib might increase the exposure to Digoxin. Manufacturer advises monitor. |
| Osimertinib | MODERATE | Osimertinib is predicted to increase the exposure to Digoxin. Manufacturer advises monitor. |
| Pemigatinib | MODERATE | Pemigatinib might increase the exposure to Digoxin. Manufacturer advises separate administration ... |
| Phenytoin | MODERATE | Phenytoin is predicted to decrease the concentration of Digoxin. Manufacturer makes no recommenda... |
| Pibrentasvir | MODERATE | Pibrentasvir with glecaprevir increases the exposure to Digoxin. Manufacturer advises caution and... |
| Pirtobrutinib | MODERATE | Pirtobrutinib slightly increases the exposure to Digoxin. Manufacturer advises avoid or monitor. |
| Ranolazine | MODERATE | Ranolazine increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concentra... |
| Ribociclib | MODERATE | Ribociclib is predicted to increase the exposure to Digoxin. Manufacturer advises monitor for tox... |
| Rifampicin | MODERATE | Rifampicin decreases the concentration of Digoxin. Manufacturer advises monitor Digoxin concentra... |
| Selpercatinib | MODERATE | Selpercatinib is predicted to increase the exposure to Digoxin. Manufacturer advises caution. |
| Sotorasib | MODERATE | Sotorasib very slightly increases the exposure to Digoxin. Manufacturer advises avoid or adjust d... |
| Spironolactone | MODERATE | Spironolactone increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Streptomycin | MODERATE | Streptomycin might increases the concentration of Digoxin. Manufacturer advises monitor and adjus... |
| Sulfasalazine | MODERATE | Sulfasalazine decreases the concentration of Digoxin. Manufacturer advises monitor Digoxin concen... |
| Ticagrelor | MODERATE | Ticagrelor increases the concentration of Digoxin. Manufacturer advises monitor. |
| Tirzepatide | MODERATE | Tirzepatide might affect the absorption of Digoxin. Manufacturer advises monitor. |
| Tobramycin | MODERATE | Tobramycin might increases the concentration of Digoxin. Manufacturer advises monitor and adjust ... |
| Tolvaptan | MODERATE | Tolvaptan slightly increases the exposure to Digoxin. Manufacturer advises monitor. |
| Trimethoprim | MODERATE | Trimethoprim increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concent... |
| Tucatinib | MODERATE | Tucatinib slightly increases the exposure to Digoxin. Manufacturer advises use with caution and a... |
| Vandetanib | MODERATE | Vandetanib very slightly increases the exposure to Digoxin. Manufacturer advises monitor. |
| Voclosporin | MODERATE | Voclosporin slightly increases the exposure to Digoxin. Manufacturer advises monitor. |
| Antacids | MILD | oral Antacids decrease the absorption of oral Digoxin. Manufacturer advises separate administrati... |
| Apalutamide | MILD | Apalutamide is predicted to decrease the exposure to Digoxin. Manufacturer advises monitor. |
| Eplerenone | MILD | Eplerenone very slightly increases the exposure to Digoxin. Manufacturer advises caution. |
| Pitolisant | MILD | Pitolisant is predicted to decrease the exposure to Digoxin. Manufacturer advises caution. |
| Acebutolol | LOW | Both Digoxin and Acebutolol can increase the risk of bradycardia. |
| Alectinib | LOW | Both Digoxin and Alectinib can increase the risk of bradycardia. |
| Alfentanil | LOW | Both Digoxin and Alfentanil can increase the risk of bradycardia. |
| Apraclonidine | LOW | Both Digoxin and Apraclonidine can increase the risk of bradycardia. |
| Atenolol | LOW | Both Digoxin and Atenolol can increase the risk of bradycardia. |
| Betaxolol | LOW | Both Digoxin and Betaxolol can increase the risk of bradycardia. |
| Bisoprolol | LOW | Both Digoxin and Bisoprolol can increase the risk of bradycardia. |
| Brigatinib | LOW | Both Digoxin and Brigatinib can increase the risk of bradycardia. |
| Brimonidine | LOW | Both Digoxin and Brimonidine can increase the risk of bradycardia. |
| Carvedilol | LOW | Both Digoxin and Carvedilol can increase the risk of bradycardia. |
| Celiprolol | LOW | Both Digoxin and Celiprolol can increase the risk of bradycardia. |
| Clonidine | LOW | Both Digoxin and Clonidine can increase the risk of bradycardia. |
| Crizotinib | LOW | Both Digoxin and Crizotinib can increase the risk of bradycardia. |
| Donepezil | LOW | Both Digoxin and Donepezil can increase the risk of bradycardia. |
| Esmolol | LOW | Both Digoxin and Esmolol can increase the risk of bradycardia. |
| Etrasimod | LOW | Both Digoxin and Etrasimod can increase the risk of bradycardia. |
| Fentanyl | LOW | Both Digoxin and Fentanyl can increase the risk of bradycardia. |
| Fingolimod | LOW | Both Digoxin and Fingolimod can increase the risk of bradycardia. |
| Flecainide | LOW | Both Digoxin and Flecainide can increase the risk of bradycardia. |
| Galantamine | LOW | Both Digoxin and Galantamine can increase the risk of bradycardia. |
| Ivabradine | LOW | Both Digoxin and Ivabradine can increase the risk of bradycardia. |
| Labetalol | LOW | Both Digoxin and Labetalol can increase the risk of bradycardia. |
| Landiolol | LOW | Both Digoxin and Landiolol can increase the risk of bradycardia. |
| Levobunolol | LOW | Both Digoxin and Levobunolol can increase the risk of bradycardia. |
| Metoprolol | LOW | Both Digoxin and Metoprolol can increase the risk of bradycardia. |
| Nadolol | LOW | Both Digoxin and Nadolol can increase the risk of bradycardia. |
| Nebivolol | LOW | Both Digoxin and Nebivolol can increase the risk of bradycardia. |
| Neostigmine | LOW | Both Digoxin and Neostigmine can increase the risk of bradycardia. |
| Ozanimod | LOW | Both Digoxin and Ozanimod can increase the risk of bradycardia. |
| Pasireotide | LOW | Both Digoxin and Pasireotide can increase the risk of bradycardia. |
| Pindolol | LOW | Both Digoxin and Pindolol can increase the risk of bradycardia. |
| Ponesimod | LOW | Both Digoxin and Ponesimod can increase the risk of bradycardia. |
| Propofol | LOW | Both Digoxin and Propofol can increase the risk of bradycardia. |
| Propranolol | LOW | Both Digoxin and Propranolol can increase the risk of bradycardia. |
| Pyridostigmine | LOW | Both Digoxin and Pyridostigmine can increase the risk of bradycardia. |
| Remifentanil | LOW | Both Digoxin and Remifentanil can increase the risk of bradycardia. |
| Rivastigmine | LOW | Both Digoxin and Rivastigmine can increase the risk of bradycardia. |
| Selegiline | LOW | Both Digoxin and Selegiline can increase the risk of bradycardia. |
| Siponimod | LOW | Both Digoxin and Siponimod can increase the risk of bradycardia. |
| Sotalol | LOW | Both Digoxin and Sotalol can increase the risk of bradycardia. |
| Sufentanil | LOW | Both Digoxin and Sufentanil can increase the risk of bradycardia. |
| Thalidomide | LOW | Both Digoxin and Thalidomide can increase the risk of bradycardia. |
| Timolol | LOW | Both Digoxin and Timolol can increase the risk of bradycardia. |
| Tizanidine | LOW | Both Digoxin and Tizanidine can increase the risk of bradycardia. |
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