Duloxetine Drug Interactions
305Total Interactions
104Severe
14Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Acalabrutinib | SEVERE | Both Duloxetine and Acalabrutinib can increase the risk of bleeding. |
| Aceclofenac | SEVERE | Both Duloxetine and Aceclofenac can increase the risk of bleeding. |
| Acenocoumarol | SEVERE | Acenocoumarol causes bleeding, as can Duloxetine ; concurrent use might increase the risk of deve... |
| Alprostadil | SEVERE | Both Duloxetine and Alprostadil can increase the risk of bleeding. |
| Alteplase | SEVERE | Alteplase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developi... |
| Anagrelide | SEVERE | Both Duloxetine and Anagrelide can increase the risk of bleeding. |
| Apixaban | SEVERE | Apixaban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developin... |
| Argatroban | SEVERE | Argatroban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Asparaginase | SEVERE | Asparaginase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of devel... |
| Aspirin | SEVERE | Both Duloxetine and Aspirin can increase the risk of bleeding. |
| Avapritinib | SEVERE | Duloxetine might increase the risk of bleeding when given with Avapritinib. Manufacturer advises ... |
| Axitinib | SEVERE | Both Duloxetine and Axitinib can increase the risk of bleeding. |
| Bemiparin | SEVERE | Bemiparin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developi... |
| Benzydamine | SEVERE | Both Duloxetine and Benzydamine can increase the risk of bleeding. |
| Bevacizumab | SEVERE | Duloxetine causes bleeding, as can Bevacizumab ; concurrent use might increase the risk of develo... |
| Bivalirudin | SEVERE | Bivalirudin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develo... |
| Bosutinib | SEVERE | Both Duloxetine and Bosutinib can increase the risk of bleeding. |
| Bromfenac | SEVERE | Both Duloxetine and Bromfenac can increase the risk of bleeding. |
| Bupropion | SEVERE | Bupropion might enhance the risk of serotonin syndrome when given with Duloxetine. MHRA advises m... |
| Cabozantinib | SEVERE | Duloxetine causes bleeding, as can Cabozantinib ; concurrent use might increase the risk of devel... |
| Cangrelor | SEVERE | Both Duloxetine and Cangrelor can increase the risk of bleeding. |
| Caplacizumab | SEVERE | Duloxetine causes bleeding, as can Caplacizumab ; concurrent use might increase the risk of devel... |
| Celecoxib | SEVERE | Both Duloxetine and Celecoxib can increase the risk of bleeding. |
| Cilostazol | SEVERE | Both Duloxetine and Cilostazol can increase the risk of bleeding. |
| Citalopram | SEVERE | Both Duloxetine and Citalopram can increase the risk of bleeding. |
| Clopidogrel | SEVERE | Both Duloxetine and Clopidogrel can increase the risk of bleeding. |
| Cobimetinib | SEVERE | Duloxetine causes bleeding, as can Cobimetinib ; concurrent use might increase the risk of develo... |
| Crisantaspase | SEVERE | Crisantaspase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of deve... |
| Dabigatran | SEVERE | Dabigatran causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Dalteparin | SEVERE | Dalteparin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Danaparoid | SEVERE | Danaparoid causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Dapoxetine | SEVERE | Both Duloxetine and Dapoxetine can increase the risk of bleeding. |
| Dasatinib | SEVERE | Both Duloxetine and Dasatinib can increase the risk of bleeding. |
| Dexketoprofen | SEVERE | Both Duloxetine and Dexketoprofen can increase the risk of bleeding. |
| Diclofenac | SEVERE | Both Duloxetine and Diclofenac can increase the risk of bleeding. |
| Dipyridamole | SEVERE | Both Duloxetine and Dipyridamole can increase the risk of bleeding. |
| Donanemab | SEVERE | Donanemab can increase the risk of bleeding when given with Duloxetine. Manufacturer makes no rec... |
| Edoxaban | SEVERE | Edoxaban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developin... |
| Eliglustat | SEVERE | Duloxetine is predicted to increase the exposure to Eliglustat. Manufacturer advises avoid or adj... |
| Enoxaparin | SEVERE | Enoxaparin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Epoprostenol | SEVERE | Both Duloxetine and Epoprostenol can increase the risk of bleeding. |
| Eptifibatide | SEVERE | Eptifibatide causes bleeding, as can Duloxetine ; concurrent use might increase the risk of devel... |
| Escitalopram | SEVERE | Both Duloxetine and Escitalopram can increase the risk of bleeding. |
| Etodolac | SEVERE | Both Duloxetine and Etodolac can increase the risk of bleeding. |
| Etoricoxib | SEVERE | Both Duloxetine and Etoricoxib can increase the risk of bleeding. |
| Fluoxetine | SEVERE | Both Duloxetine and Fluoxetine can increase the risk of bleeding. |
| Flurbiprofen | SEVERE | Both Duloxetine and Flurbiprofen can increase the risk of bleeding. |
| Fluvoxamine | SEVERE | Fluvoxamine markedly increases the exposure to Duloxetine. Manufacturer advises avoid. |
| Fondaparinux | SEVERE | Fondaparinux causes bleeding, as can Duloxetine ; concurrent use might increase the risk of devel... |
| Heparin | SEVERE | Heparin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developing... |
| Ibrutinib | SEVERE | Both Duloxetine and Ibrutinib can increase the risk of bleeding. |
| Ibuprofen | SEVERE | Both Duloxetine and Ibuprofen can increase the risk of bleeding. |
| Icosapent | SEVERE | Both Duloxetine and Icosapent can increase the risk of bleeding. |
| Iloprost | SEVERE | Both Duloxetine and Iloprost can increase the risk of bleeding. |
| Imatinib | SEVERE | Both Duloxetine and Imatinib can increase the risk of bleeding. |
| Indometacin | SEVERE | Both Duloxetine and Indometacin can increase the risk of bleeding. |
| Inotersen | SEVERE | Duloxetine causes bleeding, as can Inotersen ; concurrent use might increase the risk of developi... |
| Ketoprofen | SEVERE | Both Duloxetine and Ketoprofen can increase the risk of bleeding. |
| Ketorolac | SEVERE | Both Duloxetine and Ketorolac can increase the risk of bleeding. |
| Lecanemab | SEVERE | Lecanemab can increase the risk of bleeding when given with Duloxetine. Manufacturer makes no rec... |
| Lenvatinib | SEVERE | Both Duloxetine and Lenvatinib can increase the risk of bleeding. |
| Mefenamic acid | SEVERE | Both Duloxetine and Mefenamic acid can increase the risk of bleeding. |
| Meloxicam | SEVERE | Both Duloxetine and Meloxicam can increase the risk of bleeding. |
| Nabumetone | SEVERE | Both Duloxetine and Nabumetone can increase the risk of bleeding. |
| Naproxen | SEVERE | Both Duloxetine and Naproxen can increase the risk of bleeding. |
| Nicotinic acid | SEVERE | Nicotinic acid causes bleeding, as can Duloxetine ; concurrent use might increase the risk of dev... |
| Nintedanib | SEVERE | Both Duloxetine and Nintedanib can increase the risk of bleeding. |
| Omega-3-acid ethyl esters | SEVERE | Both Duloxetine and Omega-3-acid ethyl esters can increase the risk of bleeding. |
| Ozanimod | SEVERE | Duloxetine might increase the risk of adverse effects when given with Ozanimod. Manufacturer make... |
| Parecoxib | SEVERE | Both Duloxetine and Parecoxib can increase the risk of bleeding. |
| Paroxetine | SEVERE | Both Duloxetine and Paroxetine can increase the risk of bleeding. |
| Pazopanib | SEVERE | Both Duloxetine and Pazopanib can increase the risk of bleeding. |
| Pegaspargase | SEVERE | Pegaspargase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of devel... |
| Pentosan | SEVERE | Pentosan causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developin... |
| Phenazone | SEVERE | Both Duloxetine and Phenazone can increase the risk of bleeding. |
| Phenindione | SEVERE | Phenindione causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develo... |
| Piroxicam | SEVERE | Both Duloxetine and Piroxicam can increase the risk of bleeding. |
| Ponatinib | SEVERE | Both Duloxetine and Ponatinib can increase the risk of bleeding. |
| Prasugrel | SEVERE | Both Duloxetine and Prasugrel can increase the risk of bleeding. |
| Ranibizumab | SEVERE | Duloxetine causes bleeding, as can Ranibizumab ; concurrent use might increase the risk of develo... |
| Regorafenib | SEVERE | Both Duloxetine and Regorafenib can increase the risk of bleeding. |
| Rivaroxaban | SEVERE | Rivaroxaban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develo... |
| Ruxolitinib | SEVERE | Duloxetine causes bleeding, as can Ruxolitinib ; concurrent use might increase the risk of develo... |
| Sertraline | SEVERE | Both Duloxetine and Sertraline can increase the risk of bleeding. |
| Sorafenib | SEVERE | Both Duloxetine and Sorafenib can increase the risk of bleeding. |
| Streptokinase | SEVERE | Streptokinase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of deve... |
| Sulindac | SEVERE | Both Duloxetine and Sulindac can increase the risk of bleeding. |
| Sunitinib | SEVERE | Both Duloxetine and Sunitinib can increase the risk of bleeding. |
| Tapentadol | SEVERE | Tapentadol is predicted to increase the risk of serotonin syndrome when given with Duloxetine. Ma... |
| Tenecteplase | SEVERE | Tenecteplase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of devel... |
| Tenoxicam | SEVERE | Both Duloxetine and Tenoxicam can increase the risk of bleeding. |
| Tiaprofenic acid | SEVERE | Both Duloxetine and Tiaprofenic acid can increase the risk of bleeding. |
| Ticagrelor | SEVERE | Both Duloxetine and Ticagrelor can increase the risk of bleeding. |
| Tinzaparin | SEVERE | Tinzaparin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develop... |
| Tirofiban | SEVERE | Tirofiban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developi... |
| Tolfenamic acid | SEVERE | Both Duloxetine and Tolfenamic acid can increase the risk of bleeding. |
| Trametinib | SEVERE | Duloxetine causes bleeding, as can Trametinib ; concurrent use might increase the risk of develop... |
| Trastuzumab emtansine | SEVERE | Duloxetine causes bleeding, as can Trastuzumab emtansine ; concurrent use might increase the risk... |
| Treprostinil | SEVERE | Both Duloxetine and Treprostinil can increase the risk of bleeding. |
| Urokinase | SEVERE | Urokinase causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developi... |
| Volanesorsen | SEVERE | Duloxetine causes bleeding, as can Volanesorsen ; concurrent use might increase the risk of devel... |
| Vortioxetine | SEVERE | Both Duloxetine and Vortioxetine can increase the risk of bleeding. |
| Warfarin | SEVERE | Warfarin causes bleeding, as can Duloxetine ; concurrent use might increase the risk of developin... |
| Zanubrutinib | SEVERE | Both Duloxetine and Zanubrutinib can increase the risk of bleeding. |
| Ciprofloxacin | MODERATE | Ciprofloxacin is predicted to increase the exposure to Duloxetine. Manufacturer advises avoid. |
| Givosiran | MODERATE | Givosiran is predicted to increase the exposure to Duloxetine. Manufacturer advises use with caut... |
| Leflunomide | MODERATE | Leflunomide is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommenda... |
| Leniolisib | MODERATE | Leniolisib is predicted to increase the exposure to Duloxetine. Manufacturer advises avoid. |
| Metoprolol | MODERATE | Duloxetine is predicted to increase the exposure to Metoprolol. Manufacturer makes no recommendat... |
| Mexiletine | MODERATE | Mexiletine is predicted to increase the exposure to Duloxetine. Manufacturer makes no recommendat... |
| Osilodrostat | MODERATE | Osilodrostat is predicted to increase the exposure to Duloxetine. Manufacturer advises caution. |
| Phenytoin | MODERATE | Phenytoin is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommendation. |
| Pitolisant | MODERATE | Duloxetine is predicted to increase the exposure to Pitolisant. Manufacturer advises use with cau... |
| Rifampicin | MODERATE | Rifampicin is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommendat... |
| Ritonavir | MODERATE | Ritonavir is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommendation. |
| Rucaparib | MODERATE | Rucaparib is predicted to increase the exposure to Duloxetine. Manufacturer advises monitor and a... |
| Teriflunomide | MODERATE | Teriflunomide is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommen... |
| Vemurafenib | MODERATE | Vemurafenib is predicted to increase the exposure to Duloxetine. Manufacturer advises use with ca... |
| Agomelatine | LOW | Both Duloxetine and Agomelatine have effects on the CNS and can cause sedation, which might affec... |
| Alcohol | LOW | Both Duloxetine and Alcohol have effects on the CNS and can cause sedation, which might affect th... |
| Alfentanil | LOW | Both Duloxetine and Alfentanil have effects on the CNS and can cause sedation, which might affect... |
| Alimemazine | LOW | Both Duloxetine and Alimemazine have effects on the CNS and can cause sedation, which might affec... |
| Almotriptan | LOW | Both Duloxetine and Almotriptan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Alprazolam | LOW | Both Duloxetine and Alprazolam have effects on the CNS and can cause sedation, which might affect... |
| Amiloride | LOW | Both Duloxetine and Amiloride can increase the risk of hyponatraemia. |
| Amisulpride | LOW | Both Duloxetine and Amisulpride can increase the risk of hyponatraemia. |
| Amitriptyline | LOW | Both Duloxetine and Amitriptyline can increase the risk of hyponatraemia. |
| Apomorphine | LOW | Both Duloxetine and Apomorphine have effects on the CNS and can cause sedation, which might affec... |
| Apraclonidine | LOW | Both Duloxetine and Apraclonidine have effects on the CNS and can cause sedation, which might aff... |
| Aripiprazole | LOW | Both Duloxetine and Aripiprazole can increase the risk of hyponatraemia. |
| Asenapine | LOW | Both Duloxetine and Asenapine can increase the risk of hyponatraemia. |
| Baclofen | LOW | Both Duloxetine and Baclofen have effects on the CNS and can cause sedation, which might affect t... |
| Bendroflumethiazide | LOW | Both Duloxetine and Bendroflumethiazide can increase the risk of hyponatraemia. |
| Benperidol | LOW | Both Duloxetine and Benperidol can increase the risk of hyponatraemia. |
| Brimonidine | LOW | Both Duloxetine and Brimonidine have effects on the CNS and can cause sedation, which might affec... |
| Bromocriptine | LOW | Both Duloxetine and Bromocriptine have effects on the CNS and can cause sedation, which might aff... |
| Buclizine | LOW | Both Duloxetine and Buclizine have effects on the CNS and can cause sedation, which might affect ... |
| Bumetanide | LOW | Both Duloxetine and Bumetanide can increase the risk of hyponatraemia. |
| Buprenorphine | LOW | Both Duloxetine and Buprenorphine have effects on the CNS and can cause sedation, which might aff... |
| Cabergoline | LOW | Both Duloxetine and Cabergoline have effects on the CNS and can cause sedation, which might affec... |
| Cannabidiol | LOW | Both Duloxetine and Cannabidiol have effects on the CNS and can cause sedation, which might affec... |
| Carbamazepine | LOW | Both Duloxetine and Carbamazepine can increase the risk of hyponatraemia. |
| Carboplatin | LOW | Both Duloxetine and Carboplatin can increase the risk of hyponatraemia. |
| Cariprazine | LOW | Both Duloxetine and Cariprazine can increase the risk of hyponatraemia. |
| Cenobamate | LOW | Both Duloxetine and Cenobamate have effects on the CNS and can cause sedation, which might affect... |
| Chloral hydrate | LOW | Both Duloxetine and Chloral hydrate have effects on the CNS and can cause sedation, which might a... |
| Chlordiazepoxide | LOW | Both Duloxetine and Chlordiazepoxide have effects on the CNS and can cause sedation, which might ... |
| Chlorothiazide | LOW | Both Duloxetine and Chlorothiazide can increase the risk of hyponatraemia. |
| Chlorphenamine | LOW | Both Duloxetine and Chlorphenamine have effects on the CNS and can cause sedation, which might af... |
| Chlorpromazine | LOW | Both Duloxetine and Chlorpromazine can increase the risk of hyponatraemia. |
| Chlortalidone | LOW | Both Duloxetine and Chlortalidone can increase the risk of hyponatraemia. |
| Cinnarizine | LOW | Both Duloxetine and Cinnarizine have effects on the CNS and can cause sedation, which might affec... |
| Cisplatin | LOW | Both Duloxetine and Cisplatin can increase the risk of hyponatraemia. |
| Clobazam | LOW | Both Duloxetine and Clobazam have effects on the CNS and can cause sedation, which might affect t... |
| Clomethiazole | LOW | Both Duloxetine and Clomethiazole have effects on the CNS and can cause sedation, which might aff... |
| Clomipramine | LOW | Both Duloxetine and Clomipramine can increase the risk of hyponatraemia. |
| Clonazepam | LOW | Both Duloxetine and Clonazepam have effects on the CNS and can cause sedation, which might affect... |
| Clonidine | LOW | Both Duloxetine and Clonidine have effects on the CNS and can cause sedation, which might affect ... |
| Clozapine | LOW | Both Duloxetine and Clozapine can increase the risk of hyponatraemia. |
| Codeine | LOW | Both Duloxetine and Codeine have effects on the CNS and can cause sedation, which might affect th... |
| Cyclizine | LOW | Both Duloxetine and Cyclizine have effects on the CNS and can cause sedation, which might affect ... |
| Cyclophosphamide | LOW | Both Duloxetine and Cyclophosphamide can increase the risk of hyponatraemia. |
| Cyproheptadine | LOW | Both Duloxetine and Cyproheptadine have effects on the CNS and can cause sedation, which might af... |
| Daridorexant | LOW | Both Duloxetine and Daridorexant have effects on the CNS and can cause sedation, which might affe... |
| Desflurane | LOW | Both Duloxetine and Desflurane have effects on the CNS and can cause sedation, which might affect... |
| Desmopressin | LOW | Both Duloxetine and Desmopressin can increase the risk of hyponatraemia. |
| Dexamfetamine | LOW | Both Duloxetine and Dexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Dexmedetomidine | LOW | Both Duloxetine and Dexmedetomidine have effects on the CNS and can cause sedation, which might a... |
| Diamorphine | LOW | Both Duloxetine and Diamorphine have effects on the CNS and can cause sedation, which might affec... |
| Diazepam | LOW | Both Duloxetine and Diazepam have effects on the CNS and can cause sedation, which might affect t... |
| Difelikefalin | LOW | Both Duloxetine and Difelikefalin have effects on the CNS and can cause sedation, which might aff... |
| Dihydrocodeine | LOW | Both Duloxetine and Dihydrocodeine have effects on the CNS and can cause sedation, which might af... |
| Dimenhydrinate | LOW | Both Duloxetine and Dimenhydrinate have effects on the CNS and can cause sedation, which might af... |
| Dipipanone | LOW | Both Duloxetine and Dipipanone have effects on the CNS and can cause sedation, which might affect... |
| Dosulepin | LOW | Both Duloxetine and Dosulepin can increase the risk of hyponatraemia. |
| Doxepin | LOW | Both Duloxetine and Doxepin can increase the risk of hyponatraemia. |
| Doxylamine | LOW | Both Duloxetine and Doxylamine have effects on the CNS and can cause sedation, which might affect... |
| Dronabinol | LOW | Both Duloxetine and Dronabinol have effects on the CNS and can cause sedation, which might affect... |
| Droperidol | LOW | Both Duloxetine and Droperidol can increase the risk of hyponatraemia. |
| Eletriptan | LOW | Both Duloxetine and Eletriptan can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Esketamine | LOW | Both Duloxetine and Esketamine have effects on the CNS and can cause sedation, which might affect... |
| Eslicarbazepine | LOW | Both Duloxetine and Eslicarbazepine can increase the risk of hyponatraemia. |
| Eszopiclone | LOW | Both Duloxetine and Eszopiclone have effects on the CNS and can cause sedation, which might affec... |
| Etomidate | LOW | Both Duloxetine and Etomidate have effects on the CNS and can cause sedation, which might affect ... |
| Fenfluramine | LOW | Both Duloxetine and Fenfluramine can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Fentanyl | LOW | Both Duloxetine and Fentanyl can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Flupentixol | LOW | Both Duloxetine and Flupentixol can increase the risk of hyponatraemia. |
| Flurazepam | LOW | Both Duloxetine and Flurazepam have effects on the CNS and can cause sedation, which might affect... |
| Foslevodopa | LOW | Both Duloxetine and Foslevodopa have effects on the CNS and can cause sedation, which might affec... |
| Fosphenytoin | LOW | Both Duloxetine and Fosphenytoin have effects on the CNS and can cause sedation, which might affe... |
| Frovatriptan | LOW | Both Duloxetine and Frovatriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Furosemide | LOW | Both Duloxetine and Furosemide can increase the risk of hyponatraemia. |
| Gabapentin | LOW | Both Duloxetine and Gabapentin have effects on the CNS and can cause sedation, which might affect... |
| Granisetron | LOW | Both Duloxetine and Granisetron can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Guanfacine | LOW | Both Duloxetine and Guanfacine have effects on the CNS and can cause sedation, which might affect... |
| Haloperidol | LOW | Both Duloxetine and Haloperidol can increase the risk of hyponatraemia. |
| Hydrochlorothiazide | LOW | Both Duloxetine and Hydrochlorothiazide can increase the risk of hyponatraemia. |
| Hydroflumethiazide | LOW | Both Duloxetine and Hydroflumethiazide can increase the risk of hyponatraemia. |
| Hydromorphone | LOW | Both Duloxetine and Hydromorphone have effects on the CNS and can cause sedation, which might aff... |
| Hydroxyzine | LOW | Both Duloxetine and Hydroxyzine have effects on the CNS and can cause sedation, which might affec... |
| Imipramine | LOW | Both Duloxetine and Imipramine can increase the risk of hyponatraemia. |
| Indapamide | LOW | Both Duloxetine and Indapamide can increase the risk of hyponatraemia. |
| Isocarboxazid | LOW | Both Duloxetine and Isocarboxazid can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Isoflurane | LOW | Both Duloxetine and Isoflurane have effects on the CNS and can cause sedation, which might affect... |
| Ketamine | LOW | Both Duloxetine and Ketamine have effects on the CNS and can cause sedation, which might affect t... |
| Ketotifen | LOW | Both Duloxetine and Ketotifen have effects on the CNS and can cause sedation, which might affect ... |
| Lamotrigine | LOW | Both Duloxetine and Lamotrigine have effects on the CNS and can cause sedation, which might affec... |
| Levetiracetam | LOW | Both Duloxetine and Levetiracetam have effects on the CNS and can cause sedation, which might aff... |
| Levodopa | LOW | Both Duloxetine and Levodopa have effects on the CNS and can cause sedation, which might affect t... |
| Levomepromazine | LOW | Both Duloxetine and Levomepromazine can increase the risk of hyponatraemia. |
| Linezolid | LOW | Both Duloxetine and Linezolid can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Lisdexamfetamine | LOW | Both Duloxetine and Lisdexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin ... |
| Lithium | LOW | Both Duloxetine and Lithium can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Lofepramine | LOW | Both Duloxetine and Lofepramine can increase the risk of hyponatraemia. |
| Lofexidine | LOW | Both Duloxetine and Lofexidine have effects on the CNS and can cause sedation, which might affect... |
| Loprazolam | LOW | Both Duloxetine and Loprazolam have effects on the CNS and can cause sedation, which might affect... |
| Lorazepam | LOW | Both Duloxetine and Lorazepam have effects on the CNS and can cause sedation, which might affect ... |
| Lormetazepam | LOW | Both Duloxetine and Lormetazepam have effects on the CNS and can cause sedation, which might affe... |
| Loxapine | LOW | Both Duloxetine and Loxapine can increase the risk of hyponatraemia. |
| Lurasidone | LOW | Both Duloxetine and Lurasidone can increase the risk of hyponatraemia. |
| Mannitol | LOW | Both Duloxetine and Mannitol can increase the risk of hyponatraemia. |
| Melatonin | LOW | Both Duloxetine and Melatonin have effects on the CNS and can cause sedation, which might affect ... |
| Meptazinol | LOW | Both Duloxetine and Meptazinol have effects on the CNS and can cause sedation, which might affect... |
| Methadone | LOW | Both Duloxetine and Methadone can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Methocarbamol | LOW | Both Duloxetine and Methocarbamol have effects on the CNS and can cause sedation, which might aff... |
| Methoxyflurane | LOW | Both Duloxetine and Methoxyflurane have effects on the CNS and can cause sedation, which might af... |
| Methylthioninium chloride | LOW | Both Duloxetine and Methylthioninium chloride can increase the risk of serotonin syndrome. See 'S... |
| Metolazone | LOW | Both Duloxetine and Metolazone can increase the risk of hyponatraemia. |
| Mianserin | LOW | Both Duloxetine and Mianserin have effects on the CNS and can cause sedation, which might affect ... |
| Midazolam | LOW | Both Duloxetine and Midazolam have effects on the CNS and can cause sedation, which might affect ... |
| Mirtazapine | LOW | Both Duloxetine and Mirtazapine can increase the risk of hyponatraemia. |
| Moclobemide | LOW | Both Duloxetine and Moclobemide can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Morphine | LOW | Both Duloxetine and Morphine have effects on the CNS and can cause sedation, which might affect t... |
| Moxonidine | LOW | Both Duloxetine and Moxonidine have effects on the CNS and can cause sedation, which might affect... |
| Nabilone | LOW | Both Duloxetine and Nabilone have effects on the CNS and can cause sedation, which might affect t... |
| Naratriptan | LOW | Both Duloxetine and Naratriptan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Nitrazepam | LOW | Both Duloxetine and Nitrazepam have effects on the CNS and can cause sedation, which might affect... |
| Nitrous oxide | LOW | Both Duloxetine and Nitrous oxide have effects on the CNS and can cause sedation, which might aff... |
| Nortriptyline | LOW | Both Duloxetine and Nortriptyline can increase the risk of hyponatraemia. |
| Olanzapine | LOW | Both Duloxetine and Olanzapine can increase the risk of hyponatraemia. |
| Ondansetron | LOW | Both Duloxetine and Ondansetron can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Orphenadrine | LOW | Both Duloxetine and Orphenadrine have effects on the CNS and can cause sedation, which might affe... |
| Oxazepam | LOW | Both Duloxetine and Oxazepam have effects on the CNS and can cause sedation, which might affect t... |
| Oxcarbazepine | LOW | Both Duloxetine and Oxcarbazepine can increase the risk of hyponatraemia. |
| Oxycodone | LOW | Both Duloxetine and Oxycodone have effects on the CNS and can cause sedation, which might affect ... |
| Oxytocin | LOW | Both Duloxetine and Oxytocin can increase the risk of hyponatraemia. |
| Paliperidone | LOW | Both Duloxetine and Paliperidone can increase the risk of hyponatraemia. |
| Palonosetron | LOW | Both Duloxetine and Palonosetron can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Pentazocine | LOW | Both Duloxetine and Pentazocine can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Perampanel | LOW | Both Duloxetine and Perampanel have effects on the CNS and can cause sedation, which might affect... |
| Pericyazine | LOW | Both Duloxetine and Pericyazine can increase the risk of hyponatraemia. |
| Pethidine | LOW | Both Duloxetine and Pethidine can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Phenelzine | LOW | Both Duloxetine and Phenelzine can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Phenobarbital | LOW | Both Duloxetine and Phenobarbital have effects on the CNS and can cause sedation, which might aff... |
| Pimozide | LOW | Both Duloxetine and Pimozide can increase the risk of hyponatraemia. |
| Pizotifen | LOW | Both Duloxetine and Pizotifen have effects on the CNS and can cause sedation, which might affect ... |
| Pramipexole | LOW | Both Duloxetine and Pramipexole have effects on the CNS and can cause sedation, which might affec... |
| Pregabalin | LOW | Both Duloxetine and Pregabalin have effects on the CNS and can cause sedation, which might affect... |
| Primidone | LOW | Both Duloxetine and Primidone have effects on the CNS and can cause sedation, which might affect ... |
| Prochlorperazine | LOW | Both Duloxetine and Prochlorperazine can increase the risk of hyponatraemia. |
| Procyclidine | LOW | Both Duloxetine and Procyclidine have effects on the CNS and can cause sedation, which might affe... |
| Promazine | LOW | Both Duloxetine and Promazine can increase the risk of hyponatraemia. |
| Promethazine | LOW | Both Duloxetine and Promethazine have effects on the CNS and can cause sedation, which might affe... |
| Propofol | LOW | Both Duloxetine and Propofol have effects on the CNS and can cause sedation, which might affect t... |
| Quetiapine | LOW | Both Duloxetine and Quetiapine can increase the risk of hyponatraemia. |
| Quinagolide | LOW | Both Duloxetine and Quinagolide have effects on the CNS and can cause sedation, which might affec... |
| Rasagiline | LOW | Both Duloxetine and Rasagiline can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Remifentanil | LOW | Both Duloxetine and Remifentanil have effects on the CNS and can cause sedation, which might affe... |
| Remimazolam | LOW | Both Duloxetine and Remimazolam have effects on the CNS and can cause sedation, which might affec... |
| Risperidone | LOW | Both Duloxetine and Risperidone can increase the risk of hyponatraemia. |
| Rizatriptan | LOW | Both Duloxetine and Rizatriptan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Ropinirole | LOW | Both Duloxetine and Ropinirole have effects on the CNS and can cause sedation, which might affect... |
| Rotigotine | LOW | Both Duloxetine and Rotigotine have effects on the CNS and can cause sedation, which might affect... |
| Rufinamide | LOW | Both Duloxetine and Rufinamide have effects on the CNS and can cause sedation, which might affect... |
| Safinamide | LOW | Both Duloxetine and Safinamide can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Selegiline | LOW | Both Duloxetine and Selegiline can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Sevoflurane | LOW | Both Duloxetine and Sevoflurane have effects on the CNS and can cause sedation, which might affec... |
| Sodium oxybate | LOW | Both Duloxetine and Sodium oxybate have effects on the CNS and can cause sedation, which might af... |
| St John's wort | LOW | Both Duloxetine and St John's wort can increase the risk of serotonin syndrome. See 'Serotonin sy... |
| Sufentanil | LOW | Both Duloxetine and Sufentanil have effects on the CNS and can cause sedation, which might affect... |
| Sulpiride | LOW | Both Duloxetine and Sulpiride can increase the risk of hyponatraemia. |
| Sumatriptan | LOW | Both Duloxetine and Sumatriptan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Temazepam | LOW | Both Duloxetine and Temazepam have effects on the CNS and can cause sedation, which might affect ... |
| Tetrabenazine | LOW | Both Duloxetine and Tetrabenazine have effects on the CNS and can cause sedation, which might aff... |
| Thalidomide | LOW | Both Duloxetine and Thalidomide have effects on the CNS and can cause sedation, which might affec... |
| Thiopental | LOW | Both Duloxetine and Thiopental have effects on the CNS and can cause sedation, which might affect... |
| Tizanidine | LOW | Both Duloxetine and Tizanidine have effects on the CNS and can cause sedation, which might affect... |
| Torasemide | LOW | Both Duloxetine and Torasemide can increase the risk of hyponatraemia. |
| Tramadol | LOW | Both Duloxetine and Tramadol can increase the risk of hyponatraemia. |
| Tranylcypromine | LOW | Both Duloxetine and Tranylcypromine can increase the risk of serotonin syndrome. See 'Serotonin s... |
| Trazodone | LOW | Both Duloxetine and Trazodone can increase the risk of hyponatraemia. |
| Trifluoperazine | LOW | Both Duloxetine and Trifluoperazine can increase the risk of hyponatraemia. |
| Trihexyphenidyl | LOW | Both Duloxetine and Trihexyphenidyl have effects on the CNS and can cause sedation, which might a... |
| Trimipramine | LOW | Both Duloxetine and Trimipramine can increase the risk of hyponatraemia. |
| Tryptophan | LOW | Both Duloxetine and Tryptophan can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Valproate | LOW | Both Duloxetine and Valproate can increase the risk of hyponatraemia. |
| Vigabatrin | LOW | Both Duloxetine and Vigabatrin have effects on the CNS and can cause sedation, which might affect... |
| Vinblastine | LOW | Both Duloxetine and Vinblastine can increase the risk of hyponatraemia. |
| Vincristine | LOW | Both Duloxetine and Vincristine can increase the risk of hyponatraemia. |
| Vinorelbine | LOW | Both Duloxetine and Vinorelbine can increase the risk of hyponatraemia. |
| Xipamide | LOW | Both Duloxetine and Xipamide can increase the risk of hyponatraemia. |
| Zolmitriptan | LOW | Both Duloxetine and Zolmitriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Zolpidem | LOW | Both Duloxetine and Zolpidem have effects on the CNS and can cause sedation, which might affect t... |
| Zopiclone | LOW | Both Duloxetine and Zopiclone have effects on the CNS and can cause sedation, which might affect ... |
| Zuclopenthixol | LOW | Both Duloxetine and Zuclopenthixol can increase the risk of hyponatraemia. |
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