Levothyroxine Drug Interactions
28Total Interactions
0Severe
27Moderate
1Mild
| Drug | Severity | Summary |
|---|---|---|
| Amiodarone | MODERATE | Amiodarone is predicted to increase the risk of thyroid dysfunction when given with Levothyroxine... |
| Antacids | MODERATE | oral Antacids are predicted to decrease the absorption of oral Levothyroxine. Manufacturer advise... |
| Bulevirtide | MODERATE | Bulevirtide is predicted to increase the exposure to Levothyroxine. Manufacturer advises avoid or... |
| Calcium acetate | MODERATE | oral Calcium acetate is predicted to decrease the absorption of oral Levothyroxine. Manufacturer ... |
| Calcium carbonate | MODERATE | oral Calcium carbonate is predicted to decrease the absorption of oral Levothyroxine. Manufacture... |
| Calcium chloride | MODERATE | oral Calcium chloride is predicted to decrease the absorption of oral Levothyroxine. Manufacturer... |
| Calcium gluconate | MODERATE | oral Calcium gluconate is predicted to decrease the absorption of oral Levothyroxine. Manufacture... |
| Calcium lactate | MODERATE | oral Calcium lactate is predicted to decrease the absorption of oral Levothyroxine. Manufacturer ... |
| Calcium phosphate | MODERATE | oral Calcium phosphate is predicted to decrease the absorption of oral Levothyroxine. Manufacture... |
| Carbamazepine | MODERATE | Carbamazepine is predicted to increase the risk of hypothyroidism when given with Levothyroxine. ... |
| Digoxin | MODERATE | Levothyroxine is predicted to affect the concentration of Digoxin. Manufacturer advises monitor a... |
| Enzalutamide | MODERATE | Enzalutamide is predicted to affect the exposure to Levothyroxine. Manufacturer advises use with ... |
| Fosphenytoin | MODERATE | Fosphenytoin is predicted to increase the risk of hypothyroidism when given with Levothyroxine. M... |
| Hormone replacement therapy | MODERATE | oral Hormone replacement therapy is predicted to decrease the effects of Levothyroxine. Manufactu... |
| Imatinib | MODERATE | Imatinib causes hypothyroidism when given with Levothyroxine in thyroidectomy patients. Manufactu... |
| Iron | MODERATE | oral Iron decreases the absorption of oral Levothyroxine. Manufacturer advises separate administr... |
| Lanthanum | MODERATE | Lanthanum decreases the absorption of Levothyroxine. Manufacturer advises separate administration... |
| Nirmatrelvir | MODERATE | Nirmatrelvir boosted with ritonavir might decrease the efficacy of Levothyroxine. Manufacturer ad... |
| Phenobarbital | MODERATE | Phenobarbital is predicted to decrease the effects of Levothyroxine. Manufacturer makes no recomm... |
| Phenytoin | MODERATE | Phenytoin is predicted to increase the risk of hypothyroidism when given with Levothyroxine. Manu... |
| Primidone | MODERATE | Primidone is predicted to decrease the effects of Levothyroxine. Manufacturer makes no recommenda... |
| Ritonavir | MODERATE | Ritonavir decreases the concentration of Levothyroxine. MHRA advises monitor TSH for at least one... |
| Semaglutide | MODERATE | Semaglutide slightly increases the exposure to Levothyroxine. Manufacturer advises monitor thyroi... |
| Somapacitan | MODERATE | Somapacitan might affect the efficacy of Levothyroxine. Manufacturer advises monitor and adjust d... |
| Somatrogon | MODERATE | Somatrogon might affect the efficacy of Levothyroxine. Manufacturer advises adjust dose. |
| Sucralfate | MODERATE | Sucralfate decreases the absorption of Levothyroxine. Manufacturer advises separate administratio... |
| Sunitinib | MODERATE | Sunitinib has been reported to cause hypothyroidism when given with Levothyroxine. Manufacturer a... |
| Apalutamide | MILD | Apalutamide potentially decreases the exposure to Levothyroxine. Manufacturer advises monitor. |
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