Lithium Drug Interactions
189Total Interactions
89Severe
7Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Aceclofenac | SEVERE | Aceclofenac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Acetazolamide | SEVERE | Acetazolamide alters the concentration of Lithium. Manufacturer makes no recommendation. |
| Amitriptyline | SEVERE | Amitriptyline potentially increases the risk of neurotoxicity when given with Lithium. Manufactur... |
| Azilsartan | SEVERE | Azilsartan potentially increases the concentration of Lithium. Manufacturer advises avoid or moni... |
| Bendroflumethiazide | SEVERE | Bendroflumethiazide increases the concentration of Lithium. Manufacturer advises avoid or adjust ... |
| Benzydamine | SEVERE | Benzydamine increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Bromfenac | SEVERE | Bromfenac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Bumetanide | SEVERE | Bumetanide increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Bupropion | SEVERE | Bupropion might enhance the risk of serotonin syndrome when given with Lithium. MHRA advises moni... |
| Candesartan | SEVERE | Candesartan potentially increases the concentration of Lithium. Manufacturer advises avoid or mon... |
| Captopril | SEVERE | Captopril is predicted to increase the concentration of Lithium. Manufacturer advises monitor and... |
| Carbamazepine | SEVERE | Carbamazepine is predicted to increase the risk of neurotoxicity when given with Lithium. Manufac... |
| Celecoxib | SEVERE | Celecoxib increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Chlorothiazide | SEVERE | Chlorothiazide increases the concentration of Lithium. Manufacturer advises avoid or adjust dose ... |
| Chlorpromazine | SEVERE | Chlorpromazine potentially increases the risk of neurotoxicity when given with Lithium. Manufactu... |
| Chlortalidone | SEVERE | Chlortalidone increases the concentration of Lithium. Manufacturer advises avoid or adjust dose a... |
| Clomipramine | SEVERE | Clomipramine potentially increases the risk of neurotoxicity when given with Lithium. Manufacture... |
| Demeclocycline | SEVERE | Demeclocycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) ... |
| Dexketoprofen | SEVERE | Dexketoprofen increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Diclofenac | SEVERE | Diclofenac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Diltiazem | SEVERE | Diltiazem is predicted to increase the risk of neurotoxicity when given with Lithium. Manufacture... |
| Dosulepin | SEVERE | Dosulepin potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer a... |
| Doxepin | SEVERE | Doxepin potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer adv... |
| Doxycycline | SEVERE | Doxycycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) tox... |
| Enalapril | SEVERE | Enalapril is predicted to increase the concentration of Lithium. Manufacturer advises monitor and... |
| Eprosartan | SEVERE | Eprosartan potentially increases the concentration of Lithium. Manufacturer advises avoid or moni... |
| Eravacycline | SEVERE | Eravacycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) to... |
| Etodolac | SEVERE | Etodolac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Etoricoxib | SEVERE | Etoricoxib increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Flurbiprofen | SEVERE | Flurbiprofen increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Fosinopril | SEVERE | Fosinopril is predicted to increase the concentration of Lithium. Manufacturer advises monitor an... |
| Furosemide | SEVERE | Furosemide increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Hydrochlorothiazide | SEVERE | Hydrochlorothiazide increases the concentration of Lithium. Manufacturer advises avoid or adjust ... |
| Hydroflumethiazide | SEVERE | Hydroflumethiazide increases the concentration of Lithium. Manufacturer advises avoid or adjust d... |
| Ibuprofen | SEVERE | Ibuprofen increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Imidapril | SEVERE | Imidapril is predicted to increase the concentration of Lithium. Manufacturer advises monitor and... |
| Imipramine | SEVERE | Imipramine potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer ... |
| Indapamide | SEVERE | Indapamide increases the concentration of Lithium. Manufacturer advises avoid or adjust dose and ... |
| Indometacin | SEVERE | Indometacin increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Irbesartan | SEVERE | Irbesartan potentially increases the concentration of Lithium. Manufacturer advises avoid or moni... |
| Ketoprofen | SEVERE | Ketoprofen increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Ketorolac | SEVERE | Ketorolac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Levomepromazine | SEVERE | Levomepromazine potentially increases the risk of neurotoxicity when given with Lithium. Manufact... |
| Lisinopril | SEVERE | Lisinopril is predicted to increase the concentration of Lithium. Manufacturer advises monitor an... |
| Lofepramine | SEVERE | Lofepramine potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer... |
| Losartan | SEVERE | Losartan potentially increases the concentration of Lithium. Manufacturer advises avoid or monitor. |
| Lymecycline | SEVERE | Lymecycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) tox... |
| Mefenamic acid | SEVERE | Mefenamic acid increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Meloxicam | SEVERE | Meloxicam increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Methyldopa | SEVERE | Methyldopa increases the risk of neurotoxicity when given with Lithium. Manufacturer advises moni... |
| Metolazone | SEVERE | Metolazone increases the concentration of Lithium. Manufacturer advises avoid or adjust dose and ... |
| Metronidazole | SEVERE | Metronidazole is predicted to increase the concentration of Lithium. Manufacturer advises avoid o... |
| Minocycline | SEVERE | Minocycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) tox... |
| Nabumetone | SEVERE | Nabumetone increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Naproxen | SEVERE | Naproxen increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Nepafenac | SEVERE | Nepafenac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Nortriptyline | SEVERE | Nortriptyline potentially increases the risk of neurotoxicity when given with Lithium. Manufactur... |
| Olmesartan | SEVERE | Olmesartan potentially increases the concentration of Lithium. Manufacturer advises avoid or moni... |
| Oxcarbazepine | SEVERE | Oxcarbazepine is predicted to increase the risk of neurotoxicity when given with Lithium. Manufac... |
| Oxytetracycline | SEVERE | Oxytetracycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate)... |
| Parecoxib | SEVERE | Parecoxib increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Pericyazine | SEVERE | Pericyazine potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer... |
| Perindopril | SEVERE | Perindopril is predicted to increase the concentration of Lithium. Manufacturer advises monitor a... |
| Phenazone | SEVERE | Phenazone increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Piroxicam | SEVERE | Piroxicam increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Prochlorperazine | SEVERE | Prochlorperazine potentially increases the risk of neurotoxicity when given with Lithium. Manufac... |
| Promazine | SEVERE | Promazine potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer a... |
| Quetiapine | SEVERE | Quetiapine potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer ... |
| Quinapril | SEVERE | Quinapril is predicted to increase the concentration of Lithium. Manufacturer advises monitor and... |
| Ramipril | SEVERE | Ramipril is predicted to increase the concentration of Lithium. Manufacturer advises monitor and ... |
| Risperidone | SEVERE | Risperidone potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer... |
| Sodium bicarbonate | SEVERE | Sodium bicarbonate decreases the concentration of Lithium. Manufacturer makes no recommendation. |
| Sparsentan | SEVERE | Sparsentan might increase the concentration of Lithium. Manufacturer makes no recommendation. |
| Sulindac | SEVERE | Sulindac increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Sulpiride | SEVERE | Sulpiride potentially increases the risk of neurotoxicity when given with Lithium. Manufacturer a... |
| Tapentadol | SEVERE | Tapentadol is predicted to increase the risk of serotonin syndrome when given with Lithium. Manuf... |
| Telmisartan | SEVERE | Telmisartan potentially increases the concentration of Lithium. Manufacturer advises avoid or mon... |
| Tenoxicam | SEVERE | Tenoxicam increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Tetracycline | SEVERE | Tetracycline is predicted to increase the risk of Lithium (Lithium carbonate, Lithium citrate) to... |
| Tiaprofenic acid | SEVERE | Tiaprofenic acid increases the concentration of Lithium. Manufacturer advises monitor and adjust ... |
| Tolfenamic acid | SEVERE | Tolfenamic acid increases the concentration of Lithium. Manufacturer advises monitor and adjust d... |
| Torasemide | SEVERE | Torasemide increases the concentration of Lithium. Manufacturer advises monitor and adjust dose. |
| Trandolapril | SEVERE | Trandolapril is predicted to increase the concentration of Lithium. Manufacturer advises monitor ... |
| Trifluoperazine | SEVERE | Trifluoperazine potentially increases the risk of neurotoxicity when given with Lithium. Manufact... |
| Trimipramine | SEVERE | Trimipramine potentially increases the risk of neurotoxicity when given with Lithium. Manufacture... |
| Valsartan | SEVERE | Valsartan potentially increases the concentration of Lithium. Manufacturer advises avoid or monitor. |
| Verapamil | SEVERE | Verapamil is predicted to increase the risk of neurotoxicity when given with Lithium. Manufacture... |
| Xipamide | SEVERE | Xipamide increases the concentration of Lithium. Manufacturer advises avoid or adjust dose and mo... |
| Zuclopenthixol | SEVERE | Zuclopenthixol potentially increases the risk of neurotoxicity when given with Lithium. Manufactu... |
| Aminophylline | MODERATE | Aminophylline is predicted to decrease the concentration of Lithium. Manufacturer advises caution. |
| Calcitonins | MODERATE | Calcitonins decrease the concentration of Lithium. Manufacturer advises adjust dose. |
| Eplerenone | MODERATE | Eplerenone potentially increases the concentration of Lithium. Manufacturer advises avoid. |
| Spironolactone | MODERATE | Spironolactone potentially increases the concentration of Lithium. Manufacturer makes no recommen... |
| Theophylline | MODERATE | Theophylline is predicted to decrease the concentration of Lithium. Manufacturer advises monitor ... |
| Triamterene | MODERATE | Triamterene potentially increases the clearance of Lithium. Manufacturer makes no recommendation. |
| Vasopressin | MODERATE | Lithium might decrease the antidiuretic and hypertensive effects of Vasopressin. Manufacturer mak... |
| Aciclovir | LOW | Both Lithium and Aciclovir can increase the risk of nephrotoxicity. |
| Almotriptan | LOW | Both Lithium and Almotriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Amikacin | LOW | Both Lithium and Amikacin can increase the risk of nephrotoxicity. |
| Amphotericin B | LOW | Both Lithium and Amphotericin B can increase the risk of nephrotoxicity. |
| Aspirin | LOW | Both Lithium and Aspirin can increase the risk of nephrotoxicity. |
| Carboplatin | LOW | Both Lithium and Carboplatin can increase the risk of nephrotoxicity. |
| Cefaclor | LOW | Both Lithium and Cefaclor can increase the risk of nephrotoxicity. |
| Cefadroxil | LOW | Both Lithium and Cefadroxil can increase the risk of nephrotoxicity. |
| Cefalexin | LOW | Both Lithium and Cefalexin can increase the risk of nephrotoxicity. |
| Cefazolin | LOW | Both Lithium and Cefazolin can increase the risk of nephrotoxicity. |
| Cefepime | LOW | Both Lithium and Cefepime can increase the risk of nephrotoxicity. |
| Cefixime | LOW | Both Lithium and Cefixime can increase the risk of nephrotoxicity. |
| Cefotaxime | LOW | Both Lithium and Cefotaxime can increase the risk of nephrotoxicity. |
| Cefoxitin | LOW | Both Lithium and Cefoxitin can increase the risk of nephrotoxicity. |
| Cefradine | LOW | Both Lithium and Cefradine can increase the risk of nephrotoxicity. |
| Ceftaroline | LOW | Both Lithium and Ceftaroline can increase the risk of nephrotoxicity. |
| Ceftazidime | LOW | Both Lithium and Ceftazidime can increase the risk of nephrotoxicity. |
| Ceftobiprole | LOW | Both Lithium and Ceftobiprole can increase the risk of nephrotoxicity. |
| Ceftolozane | LOW | Both Lithium and Ceftolozane can increase the risk of nephrotoxicity. |
| Ceftriaxone | LOW | Both Lithium and Ceftriaxone can increase the risk of nephrotoxicity. |
| Cefuroxime | LOW | Both Lithium and Cefuroxime can increase the risk of nephrotoxicity. |
| Ciclosporin | LOW | Both Lithium and Ciclosporin can increase the risk of nephrotoxicity. |
| Cidofovir | LOW | Both Lithium and Cidofovir can increase the risk of nephrotoxicity. |
| Cisplatin | LOW | Both Lithium and Cisplatin can increase the risk of nephrotoxicity. |
| Citalopram | LOW | Both Lithium and Citalopram can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Colistimethate | LOW | Both Lithium and Colistimethate can increase the risk of nephrotoxicity. |
| Dapoxetine | LOW | Both Lithium and Dapoxetine can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Deferasirox | LOW | Both Lithium and Deferasirox can increase the risk of nephrotoxicity. |
| Dexamfetamine | LOW | Both Lithium and Dexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Duloxetine | LOW | Both Lithium and Duloxetine can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Eletriptan | LOW | Both Lithium and Eletriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Escitalopram | LOW | Both Lithium and Escitalopram can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Fenfluramine | LOW | Both Lithium and Fenfluramine can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Fentanyl | LOW | Both Lithium and Fentanyl can increase the risk of serotonin syndrome. See 'Serotonin syndrome' a... |
| Fluoxetine | LOW | Both Lithium and Fluoxetine can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Fluvoxamine | LOW | Both Lithium and Fluvoxamine can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Foscarnet | LOW | Both Lithium and Foscarnet can increase the risk of nephrotoxicity. |
| Frovatriptan | LOW | Both Lithium and Frovatriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Ganciclovir | LOW | Both Lithium and Ganciclovir can increase the risk of nephrotoxicity. |
| Gentamicin | LOW | Both Lithium and Gentamicin can increase the risk of nephrotoxicity. |
| Granisetron | LOW | Both Lithium and Granisetron can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Ifosfamide | LOW | Both Lithium and Ifosfamide can increase the risk of nephrotoxicity. |
| Inotersen | LOW | Both Lithium and Inotersen can increase the risk of nephrotoxicity. |
| Isocarboxazid | LOW | Both Lithium and Isocarboxazid can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Linezolid | LOW | Both Lithium and Linezolid can increase the risk of serotonin syndrome. See 'Serotonin syndrome' ... |
| Lisdexamfetamine | LOW | Both Lithium and Lisdexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Mesalazine | LOW | Both Lithium and Mesalazine can increase the risk of nephrotoxicity. |
| Methadone | LOW | Both Lithium and Methadone can increase the risk of serotonin syndrome. See 'Serotonin syndrome' ... |
| Methotrexate | LOW | Both Lithium and Methotrexate can increase the risk of nephrotoxicity. |
| Methylthioninium chloride | LOW | Both Lithium and Methylthioninium chloride can increase the risk of serotonin syndrome. See 'Sero... |
| Mirtazapine | LOW | Both Lithium and Mirtazapine can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Moclobemide | LOW | Both Lithium and Moclobemide can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Naratriptan | LOW | Both Lithium and Naratriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Neomycin | LOW | Both Lithium and Neomycin can increase the risk of nephrotoxicity. |
| Netilmicin | LOW | Both Lithium and Netilmicin can increase the risk of nephrotoxicity. |
| Ondansetron | LOW | Both Lithium and Ondansetron can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Oxaliplatin | LOW | Both Lithium and Oxaliplatin can increase the risk of nephrotoxicity. |
| Palonosetron | LOW | Both Lithium and Palonosetron can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Pamidronate | LOW | Both Lithium and Pamidronate can increase the risk of nephrotoxicity. |
| Paroxetine | LOW | Both Lithium and Paroxetine can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Pemetrexed | LOW | Both Lithium and Pemetrexed can increase the risk of nephrotoxicity. |
| Pentamidine | LOW | Both Lithium and Pentamidine can increase the risk of nephrotoxicity. |
| Pentazocine | LOW | Both Lithium and Pentazocine can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Pethidine | LOW | Both Lithium and Pethidine can increase the risk of serotonin syndrome. See 'Serotonin syndrome' ... |
| Phenelzine | LOW | Both Lithium and Phenelzine can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Rasagiline | LOW | Both Lithium and Rasagiline can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Rifampicin | LOW | Both Lithium and Rifampicin can increase the risk of nephrotoxicity. |
| Rizatriptan | LOW | Both Lithium and Rizatriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Safinamide | LOW | Both Lithium and Safinamide can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Selegiline | LOW | Both Lithium and Selegiline can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Sertraline | LOW | Both Lithium and Sertraline can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| St John's wort | LOW | Both Lithium and St John's wort can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Streptomycin | LOW | Both Lithium and Streptomycin can increase the risk of nephrotoxicity. |
| Streptozocin | LOW | Both Lithium and Streptozocin can increase the risk of nephrotoxicity. |
| Sulfasalazine | LOW | Both Lithium and Sulfasalazine can increase the risk of nephrotoxicity. |
| Sumatriptan | LOW | Both Lithium and Sumatriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Tacrolimus | LOW | Both Lithium and Tacrolimus can increase the risk of nephrotoxicity. |
| Tenofovir disoproxil | LOW | Both Lithium and Tenofovir disoproxil can increase the risk of nephrotoxicity. |
| Tobramycin | LOW | Both Lithium and Tobramycin can increase the risk of nephrotoxicity. |
| Tramadol | LOW | Both Lithium and Tramadol can increase the risk of serotonin syndrome. See 'Serotonin syndrome' a... |
| Tranylcypromine | LOW | Both Lithium and Tranylcypromine can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Trazodone | LOW | Both Lithium and Trazodone can increase the risk of serotonin syndrome. See 'Serotonin syndrome' ... |
| Trimethoprim | LOW | Both Lithium and Trimethoprim can increase the risk of nephrotoxicity. |
| Tryptophan | LOW | Both Lithium and Tryptophan can increase the risk of serotonin syndrome. See 'Serotonin syndrome'... |
| Valaciclovir | LOW | Both Lithium and Valaciclovir can increase the risk of nephrotoxicity. |
| Valganciclovir | LOW | Both Lithium and Valganciclovir can increase the risk of nephrotoxicity. |
| Vancomycin | LOW | Both Lithium and Vancomycin can increase the risk of nephrotoxicity. |
| Venlafaxine | LOW | Both Lithium and Venlafaxine can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Voclosporin | LOW | Both Lithium and Voclosporin can increase the risk of nephrotoxicity. |
| Vortioxetine | LOW | Both Lithium and Vortioxetine can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Zoledronate | LOW | Both Lithium and Zoledronate can increase the risk of nephrotoxicity. |
| Zolmitriptan | LOW | Both Lithium and Zolmitriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Mexiletine | UNKNOWN | Mexiletine potentially affects the exposure to Lithium. Manufacturer advises avoid. |
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