Metformin Drug Interactions
43Total Interactions
1Severe
16Moderate
1Mild
| Drug | Severity | Summary |
|---|---|---|
| Sultiame | SEVERE | Sultiame might increase the risk of lactic acidosis when given with Metformin. Manufacturer makes... |
| Alcohol | MODERATE | Alcohol (excessive consumption) potentially increases the risk of lactic acidosis when given with... |
| Bictegravir | MODERATE | Bictegravir slightly increases the exposure to Metformin. Manufacturer advises monitor in renal i... |
| Cimetidine | MODERATE | Cimetidine is predicted to increase the exposure to Metformin. Manufacturer advises use with caut... |
| Dolutegravir | MODERATE | Dolutegravir is predicted to increase the exposure to Metformin. Manufacturer advises use with ca... |
| Fenfluramine | MODERATE | Fenfluramine might decrease blood glucose concentrations when given with Metformin. Manufacturer ... |
| Givinostat | MODERATE | Givinostat might increase the exposure to Metformin. Manufacturer advises monitor. |
| Guanfacine | MODERATE | Guanfacine is predicted to increase the concentration of Metformin. Manufacturer makes no recomme... |
| Isavuconazole | MODERATE | Isavuconazole is predicted to increase the exposure to Metformin. Manufacturer advises use with c... |
| Pyrimethamine | MODERATE | Pyrimethamine is predicted to increase the exposure to Metformin. Manufacturer advises use with c... |
| Ranolazine | MODERATE | Ranolazine is predicted to increase the exposure to Metformin. Manufacturer advises use with caut... |
| Ribociclib | MODERATE | Ribociclib is predicted to increase the exposure to Metformin. Manufacturer advises monitor for t... |
| Risdiplam | MODERATE | Risdiplam is predicted to increase the concentration of Metformin. Manufacturer advises monitor a... |
| Somapacitan | MODERATE | Somapacitan might increase blood glucose concentrations, opposing the blood glucose-lowering effe... |
| Somatrogon | MODERATE | Somatrogon might increase blood glucose concentrations, opposing the blood glucose-lowering effec... |
| Trimethoprim | MODERATE | Trimethoprim is predicted to increase the exposure to Metformin. Manufacturer advises use with ca... |
| Vandetanib | MODERATE | Vandetanib is predicted to increase the exposure to Metformin. Manufacturer advises use with caut... |
| Pitolisant | MILD | Pitolisant is predicted to increase the exposure to Metformin. Manufacturer advises caution. |
| Acarbose | LOW | Both Metformin and Acarbose can increase the risk of hypoglycaemia. |
| Alogliptin | LOW | Both Metformin and Alogliptin can increase the risk of hypoglycaemia. |
| Canagliflozin | LOW | Both Metformin and Canagliflozin can increase the risk of hypoglycaemia. |
| Dapagliflozin | LOW | Both Metformin and Dapagliflozin can increase the risk of hypoglycaemia. |
| Dulaglutide | LOW | Both Metformin and Dulaglutide can increase the risk of hypoglycaemia. |
| Empagliflozin | LOW | Both Metformin and Empagliflozin can increase the risk of hypoglycaemia. |
| Ertugliflozin | LOW | Both Metformin and Ertugliflozin can increase the risk of hypoglycaemia. |
| Exenatide | LOW | Both Metformin and Exenatide can increase the risk of hypoglycaemia. |
| Glibenclamide | LOW | Both Metformin and Glibenclamide can increase the risk of hypoglycaemia. |
| Gliclazide | LOW | Both Metformin and Gliclazide can increase the risk of hypoglycaemia. |
| Glimepiride | LOW | Both Metformin and Glimepiride can increase the risk of hypoglycaemia. |
| Glipizide | LOW | Both Metformin and Glipizide can increase the risk of hypoglycaemia. |
| Insulin | LOW | Both Metformin and Insulin can increase the risk of hypoglycaemia. |
| Linagliptin | LOW | Both Metformin and Linagliptin can increase the risk of hypoglycaemia. |
| Liraglutide | LOW | Both Metformin and Liraglutide can increase the risk of hypoglycaemia. |
| Lixisenatide | LOW | Both Metformin and Lixisenatide can increase the risk of hypoglycaemia. |
| Pioglitazone | LOW | Both Metformin and Pioglitazone can increase the risk of hypoglycaemia. |
| Repaglinide | LOW | Both Metformin and Repaglinide can increase the risk of hypoglycaemia. |
| Saxagliptin | LOW | Both Metformin and Saxagliptin can increase the risk of hypoglycaemia. |
| Semaglutide | LOW | Both Metformin and Semaglutide can increase the risk of hypoglycaemia. |
| Sitagliptin | LOW | Both Metformin and Sitagliptin can increase the risk of hypoglycaemia. |
| Tirzepatide | LOW | Both Metformin and Tirzepatide can increase the risk of hypoglycaemia. |
| Tolbutamide | LOW | Both Metformin and Tolbutamide can increase the risk of hypoglycaemia. |
| Vildagliptin | LOW | Both Metformin and Vildagliptin can increase the risk of hypoglycaemia. |
| Mexiletine | UNKNOWN | Mexiletine is predicted to affect the exposure to Metformin. Manufacturer advises monitor. |
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