Phenytoin Drug Interactions
468Total Interactions
174Severe
177Moderate
6Mild
| Drug | Severity | Summary |
|---|---|---|
| Abemaciclib | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Abemaciclib. Manufacturer advises avoid. |
| Abiraterone | SEVERE | Phenytoin is predicted to decrease the exposure to Abiraterone. Manufacturer advises avoid. |
| Acalabrutinib | SEVERE | Phenytoin is predicted to decrease the exposure to Acalabrutinib. Manufacturer advises avoid. |
| Amiodarone | SEVERE | Amiodarone is predicted to slightly increase the concentration of Phenytoin. Manufacturer advises... |
| Apixaban | SEVERE | Phenytoin decreases the exposure to Apixaban. Manufacturer advises use with caution or avoid. |
| Apremilast | SEVERE | Phenytoin moderately decreases the exposure to Apremilast. Manufacturer advises avoid. |
| Artemether | SEVERE | Phenytoin is predicted to decrease the exposure to Artemether with lumefantrine. Manufacturer adv... |
| Artesunate | SEVERE | Phenytoin might decrease the exposure to the active metabolite of Artesunate. Manufacturer advise... |
| Atazanavir | SEVERE | Atazanavir is predicted to affect the exposure to Phenytoin and Phenytoin decreases the concentra... |
| Avacopan | SEVERE | Phenytoin is predicted to decrease the exposure to Avacopan. Manufacturer advises avoid or monitor. |
| Avanafil | SEVERE | Phenytoin is predicted to decrease the exposure to Avanafil. Manufacturer advises avoid. |
| Avapritinib | SEVERE | Phenytoin is predicted to decrease the exposure to Avapritinib. Manufacturer advises avoid. |
| Bedaquiline | SEVERE | Phenytoin decreases the exposure to Bedaquiline. Manufacturer advises avoid. |
| Belumosudil | SEVERE | Phenytoin is predicted to decrease the exposure to Belumosudil. Manufacturer advises adjust Belum... |
| Bleomycin | SEVERE | Bleomycin -containing cytotoxic regimens might affect the concentration of Phenytoin. Manufacture... |
| Bortezomib | SEVERE | Phenytoin slightly decreases the exposure to Bortezomib. Manufacturer advises avoid. |
| Bosentan | SEVERE | Phenytoin affects the exposure to Bosentan. Manufacturer advises avoid. |
| Bosutinib | SEVERE | Phenytoin is predicted to very markedly decrease the exposure to Bosutinib. Manufacturer advises ... |
| Brigatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Brigatinib. Manufacturer advises avoid. |
| Bupropion | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Bupropion. Manufacturer advises caution. |
| Buspirone | SEVERE | Phenytoin is predicted to decrease the exposure to Buspirone. Manufacturer advises use with cauti... |
| Cabotegravir | SEVERE | Phenytoin might decrease the concentration of Cabotegravir. Manufacturer advises avoid. |
| Capecitabine | SEVERE | Capecitabine increases the concentration of Phenytoin. Manufacturer advises caution and monitor c... |
| Carbamazepine | SEVERE | Carbamazepine affects the concentration of Phenytoin and Phenytoin decreases the concentration of... |
| Cariprazine | SEVERE | Phenytoin is predicted to decrease the exposure to Cariprazine. Manufacturer advises avoid. |
| Ceritinib | SEVERE | Phenytoin is predicted to decrease the exposure to Ceritinib. Manufacturer advises avoid. |
| Chloramphenicol | SEVERE | intravenous Chloramphenicol increases the concentration of Phenytoin and Phenytoin affects the co... |
| Chlordiazepoxide | SEVERE | Chlordiazepoxide affects the concentration of Phenytoin. Manufacturer makes no recommendation. |
| Ciclosporin | SEVERE | Phenytoin decreases the concentration of Ciclosporin. Manufacturer advises caution. |
| Cimetidine | SEVERE | Cimetidine increases the concentration of Phenytoin. Manufacturer advises monitor concentration a... |
| Ciprofloxacin | SEVERE | Ciprofloxacin affects the concentration of Phenytoin. Manufacturer advises monitor concentration ... |
| Clobazam | SEVERE | Clobazam potentially affects the concentration of Phenytoin. Manufacturer makes no recommendation. |
| Clonazepam | SEVERE | Clonazepam potentially affects the concentration of Phenytoin. Manufacturer makes no recommendation. |
| Cobicistat | SEVERE | Phenytoin is predicted to decrease the exposure to Cobicistat. Manufacturer advises avoid. |
| Cobimetinib | SEVERE | Phenytoin is predicted to decrease the exposure to Cobimetinib. Manufacturer advises avoid. |
| Combined hormonal contraceptives | SEVERE | Phenytoin is predicted to decrease the efficacy of Combined hormonal contraceptives. For CoSRH gu... |
| Crizotinib | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Crizotinib. Manufacturer advises avoid. |
| Cyproterone | SEVERE | Phenytoin is predicted to decrease the efficacy of Cyproterone with ethinylestradiol (co-cyprindi... |
| Dabigatran | SEVERE | Phenytoin is predicted to decrease the exposure to Dabigatran. Manufacturer advises avoid. |
| Daridorexant | SEVERE | Phenytoin is predicted to decrease the exposure to Daridorexant. Manufacturer makes no recommenda... |
| Darunavir | SEVERE | Darunavir is predicted to affect the exposure to Phenytoin and Phenytoin decreases the concentrat... |
| Dasatinib | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Dasatinib. Manufacturer advises avoid. |
| Desogestrel | SEVERE | Phenytoin is predicted to decrease the efficacy of Desogestrel. For CoSRH guidance, see Contracep... |
| Deutivacaftor | SEVERE | Phenytoin is predicted to decrease the exposure to Deutivacaftor. Manufacturer advises avoid. |
| Dexrazoxane | SEVERE | Dexrazoxane might decrease the absorption of Phenytoin. Manufacturer advises avoid. |
| Diazepam | SEVERE | Diazepam potentially affects the concentration of Phenytoin. Manufacturer advises monitor concent... |
| Dienogest | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Dienogest. Manufacturer makes no reco... |
| Diltiazem | SEVERE | Diltiazem potentially increases the concentration of Phenytoin and Phenytoin is predicted to decr... |
| Disopyramide | SEVERE | Phenytoin is predicted to decrease the exposure to Disopyramide. Manufacturer advises avoid. |
| Disulfiram | SEVERE | Disulfiram increases the concentration of Phenytoin. Manufacturer advises monitor concentration a... |
| Docetaxel | SEVERE | Phenytoin is predicted to decrease the exposure to Docetaxel. Manufacturer advises caution. |
| Dolutegravir | SEVERE | Phenytoin is predicted to decrease the exposure to Dolutegravir. Manufacturer advises adjust Dolu... |
| Doravirine | SEVERE | Phenytoin is predicted to decrease the exposure to Doravirine. Manufacturer advises avoid. |
| Dronedarone | SEVERE | Phenytoin is predicted to decrease the exposure to Dronedarone. Manufacturer advises avoid. |
| Drospirenone | SEVERE | Phenytoin is predicted to decrease the efficacy of Drospirenone. For CoSRH guidance, see Contrace... |
| Edoxaban | SEVERE | Phenytoin is predicted to decrease the exposure to Edoxaban. Manufacturer advises caution. |
| Efavirenz | SEVERE | Phenytoin slightly decreases the exposure to Efavirenz and Efavirenz affects the concentration of... |
| Elacestrant | SEVERE | Phenytoin is predicted to decrease the exposure to Elacestrant. Manufacturer advises avoid or adj... |
| Elbasvir | SEVERE | Phenytoin is predicted to decrease the exposure to Elbasvir. Manufacturer advises avoid. |
| Elexacaftor | SEVERE | Phenytoin is predicted to decreases the exposure to Elexacaftor. Manufacturer advises avoid. |
| Eliglustat | SEVERE | Phenytoin is predicted to decrease the exposure to Eliglustat. Manufacturer advises avoid. |
| Elvitegravir | SEVERE | Phenytoin is predicted to decrease the concentration of Elvitegravir. Manufacturer advises avoid. |
| Encorafenib | SEVERE | Phenytoin is predicted to decrease the exposure to Encorafenib. Manufacturer advises consider alt... |
| Enteral feeds | SEVERE | Enteral feeds decrease the absorption of Phenytoin. Manufacturer makes no recommendation. |
| Entrectinib | SEVERE | Phenytoin is predicted to decrease the exposure to Entrectinib. Manufacturer advises avoid. |
| Erdafitinib | SEVERE | Phenytoin is predicted to decrease the exposure to Erdafitinib. Manufacturer advises avoid. |
| Erlotinib | SEVERE | Phenytoin is predicted to decrease the exposure to Erlotinib. Manufacturer advises avoid or adjus... |
| Etonogestrel | SEVERE | Phenytoin is predicted to decrease the efficacy of Etonogestrel. For CoSRH guidance, see Contrace... |
| Etravirine | SEVERE | Phenytoin is predicted to decrease the exposure to Etravirine. Manufacturer advises avoid. |
| Everolimus | SEVERE | Phenytoin is predicted to decrease the concentration of Everolimus. Manufacturer advises avoid or... |
| Finerenone | SEVERE | Phenytoin is predicted to decrease the exposure to Finerenone. Manufacturer advises avoid. |
| Fluorouracil | SEVERE | Fluorouracil increases the concentration of Phenytoin. Manufacturer advises monitor concentration... |
| Fluoxetine | SEVERE | Fluoxetine is predicted to increase the concentration of Phenytoin. Manufacturer advises monitor ... |
| Fluvoxamine | SEVERE | Fluvoxamine is predicted to increase the concentration of Phenytoin. Manufacturer advises monitor... |
| Folic acid | SEVERE | Folic acid is predicted to decrease the concentration of Phenytoin. Manufacturer advises monitor ... |
| Folinic acid | SEVERE | Folinic acid is predicted to decrease the concentration of Phenytoin. Manufacturer advises monito... |
| Fosamprenavir | SEVERE | Fosamprenavir is predicted to affect the exposure to Phenytoin and Phenytoin decreases the concen... |
| Fostamatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Fostamatinib. Manufacturer advises avoid. |
| Fostemsavir | SEVERE | Phenytoin is predicted to decrease the exposure to the active metabolite of Fostemsavir. Manufact... |
| Gefitinib | SEVERE | Phenytoin is predicted to decrease the exposure to Gefitinib. Manufacturer advises avoid. |
| Gilteritinib | SEVERE | Phenytoin is predicted to decrease the exposure to Gilteritinib. Manufacturer advises avoid. |
| Glasdegib | SEVERE | Phenytoin is predicted to decrease the exposure to Glasdegib. Manufacturer advises avoid. |
| Glecaprevir | SEVERE | Phenytoin is predicted to moderately decrease the exposure to Glecaprevir. Manufacturer advises a... |
| Grazoprevir | SEVERE | Phenytoin is predicted to decrease the exposure to Grazoprevir. Manufacturer advises avoid. |
| Ibrutinib | SEVERE | Phenytoin is predicted to decrease the exposure to Ibrutinib. Manufacturer advises avoid or monitor. |
| Idelalisib | SEVERE | Phenytoin is predicted to decrease the exposure to Idelalisib. Manufacturer advises avoid. |
| Irinotecan | SEVERE | Phenytoin is predicted to decrease the exposure to Irinotecan. Manufacturer advises avoid. |
| Isavuconazole | SEVERE | Phenytoin is predicted to decrease the exposure to Isavuconazole. Manufacturer advises avoid. |
| Ivacaftor | SEVERE | Phenytoin is predicted to decrease the exposure to Ivacaftor. Manufacturer advises avoid. |
| Ivosidenib | SEVERE | Phenytoin is predicted to decrease the exposure to Ivosidenib and Ivosidenib might decrease the e... |
| Ixazomib | SEVERE | Phenytoin is predicted to decrease the exposure to Ixazomib. Manufacturer advises avoid. |
| Lapatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Lapatinib. Manufacturer advises avoid. |
| Lazertinib | SEVERE | Phenytoin is predicted to decrease the exposure to Lazertinib. Manufacturer advises avoid. |
| Ledipasvir | SEVERE | Phenytoin is predicted to decrease the exposure to Ledipasvir. Manufacturer advises avoid. |
| Lenacapavir | SEVERE | Phenytoin is predicted to decrease the exposure to Lenacapavir. Manufacturer advises avoid. |
| Leniolisib | SEVERE | Phenytoin is predicted to decrease the exposure to Leniolisib. Manufacturer advises avoid. |
| Levofolinic acid | SEVERE | Levofolinic acid is predicted to decrease the concentration of Phenytoin. Manufacturer advises mo... |
| Levonorgestrel | SEVERE | Phenytoin is predicted to decrease the efficacy of some contraceptive methods containing Levonorg... |
| Lidocaine | SEVERE | Phenytoin is predicted to decrease the exposure to Lidocaine. Manufacturer makes no recommendation. |
| Lopinavir | SEVERE | Lopinavir is predicted to affect the exposure to Phenytoin and Phenytoin decreases the concentrat... |
| Lorlatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Lorlatinib. Manufacturer advises avoid. |
| Lumacaftor | SEVERE | Lumacaftor is predicted to decrease the exposure to Phenytoin. Manufacturer advises avoid. |
| Macitentan | SEVERE | Phenytoin is predicted to decrease the exposure to Macitentan. Manufacturer advises avoid. |
| Maraviroc | SEVERE | Phenytoin is predicted to decrease the exposure to Maraviroc. Manufacturer advises adjust dose. |
| Maribavir | SEVERE | Phenytoin is predicted to decrease the exposure to Maribavir. Manufacturer advises avoid or adjus... |
| Mavacamten | SEVERE | Phenytoin is predicted to decrease the exposure to Mavacamten. Manufacturer advises monitor and a... |
| Methadone | SEVERE | Phenytoin decreases the exposure to Methadone. Manufacturer advises monitor and adjust dose. |
| Miconazole | SEVERE | Miconazole increases the risk of Phenytoin toxicity when given with Phenytoin. Manufacturer advis... |
| Midazolam | SEVERE | Phenytoin is predicted to decrease the exposure to Midazolam. Manufacturer advises monitor and ad... |
| Midostaurin | SEVERE | Phenytoin is predicted to decrease the exposure to Midostaurin. Manufacturer advises avoid. |
| Mifepristone | SEVERE | Phenytoin is predicted to decrease the exposure to Mifepristone. Manufacturer advises adjust Mife... |
| Naldemedine | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Naldemedine. Manufacturer advises avoid. |
| Neratinib | SEVERE | Phenytoin is predicted to decrease the exposure to Neratinib. Manufacturer advises avoid. |
| Netupitant | SEVERE | Phenytoin is predicted to decrease the exposure to Netupitant. Manufacturer advises avoid. |
| Nevirapine | SEVERE | Nevirapine is predicted to decrease the concentration of Phenytoin and Phenytoin is predicted to ... |
| Nilotinib | SEVERE | Phenytoin is predicted to moderately decrease the exposure to Nilotinib. Manufacturer advises avoid. |
| Nintedanib | SEVERE | Phenytoin is predicted to decrease the exposure to Nintedanib. Manufacturer advises consider alte... |
| Nirmatrelvir | SEVERE | Phenytoin is predicted to decrease the exposure to Nirmatrelvir boosted with ritonavir. Manufactu... |
| Norethisterone | SEVERE | Phenytoin is predicted to decrease the efficacy of some contraceptive methods containing Norethis... |
| Omaveloxolone | SEVERE | Phenytoin is predicted to decrease the exposure to Omaveloxolone. Manufacturer advises avoid. |
| Paclitaxel | SEVERE | Phenytoin is predicted to decrease the exposure to Paclitaxel. Manufacturer advises avoid. |
| Palbociclib | SEVERE | Phenytoin is predicted to decrease the exposure to Palbociclib. Manufacturer advises avoid. |
| Paliperidone | SEVERE | Phenytoin is predicted to decrease the exposure to Paliperidone. Manufacturer advises monitor and... |
| Pazopanib | SEVERE | Phenytoin is predicted to decrease the exposure to Pazopanib. Manufacturer advises avoid. |
| Pemigatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Pemigatinib. Manufacturer advises avoid. |
| Pibrentasvir | SEVERE | Phenytoin is predicted to moderately to markedly decrease the exposure to Pibrentasvir. Manufactu... |
| Procarbazine | SEVERE | Phenytoin is predicted to increase the risk of hypersensitivity reactions when given with Procarb... |
| Pyrimethamine | SEVERE | Pyrimethamine increases the risk of haematological toxicity when given with Phenytoin. Manufactur... |
| Quizartinib | SEVERE | Phenytoin is predicted to decrease the exposure to Quizartinib. Manufacturer advises avoid. |
| Ranolazine | SEVERE | Phenytoin is predicted to decrease the exposure to Ranolazine. Manufacturer advises avoid. |
| Ribociclib | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Ribociclib. Manufacturer advises avoid. |
| Rilpivirine | SEVERE | Phenytoin markedly decreases the exposure to Rilpivirine. Manufacturer advises avoid. |
| Ripretinib | SEVERE | Phenytoin is predicted to decrease the exposure to Ripretinib. Manufacturer advises avoid or adju... |
| Ritonavir | SEVERE | Ritonavir is predicted to affect the exposure to Phenytoin and Phenytoin decreases the concentrat... |
| Rivaroxaban | SEVERE | Phenytoin decreases the exposure to Rivaroxaban. Manufacturer advises avoid unless patient can be... |
| Sacituzumab govitecan | SEVERE | Phenytoin is predicted to decrease the exposure to the active component of Sacituzumab govitecan.... |
| Selumetinib | SEVERE | Phenytoin is predicted to decrease the exposure to Selumetinib. Manufacturer advises avoid. |
| Sertraline | SEVERE | Sertraline potentially increases the risk of toxicity when given with Phenytoin. Manufacturer adv... |
| Siponimod | SEVERE | Phenytoin is predicted to decrease the exposure to Siponimod. Manufacturer advises caution depend... |
| Sirolimus | SEVERE | Phenytoin is predicted to decrease the concentration of Sirolimus. Manufacturer advises avoid or ... |
| Sofosbuvir | SEVERE | Phenytoin is predicted to decrease the exposure to Sofosbuvir. Manufacturer advises avoid. |
| Sotorasib | SEVERE | Phenytoin is predicted to decrease the exposure to Sotorasib. Manufacturer advises avoid. |
| Sparsentan | SEVERE | Phenytoin is predicted to decrease the exposure to Sparsentan. Manufacturer advises avoid. |
| St John's wort | SEVERE | St John's wort is predicted to decrease the concentration of Phenytoin. Manufacturer advises avoid. |
| Stiripentol | SEVERE | Stiripentol is predicted to increase the concentration of Phenytoin. Manufacturer advises avoid i... |
| Sultiame | SEVERE | Sultiame might increase the concentration of Phenytoin. Manufacturer advises monitor concentration. |
| Tacrolimus | SEVERE | Phenytoin decreases the concentration of Tacrolimus. Manufacturer advises avoid or monitor and ad... |
| Tadalafil | SEVERE | Phenytoin is predicted to decrease the exposure to Tadalafil. Manufacturer advises avoid. |
| Tamoxifen | SEVERE | Tamoxifen (high-dose) might increase the concentration of Phenytoin and Phenytoin might decrease ... |
| Tegafur | SEVERE | Tegafur potentially increases the concentration of Phenytoin. Manufacturer advises monitor concen... |
| Temsirolimus | SEVERE | Phenytoin is predicted to decrease the concentration of Temsirolimus. Manufacturer advises avoid. |
| Tezacaftor | SEVERE | Phenytoin is predicted to decrease the exposure to Tezacaftor. Manufacturer advises avoid. |
| Ticagrelor | SEVERE | Phenytoin is predicted to markedly decrease the exposure to Ticagrelor. Manufacturer advises avoid. |
| Tivozanib | SEVERE | Phenytoin is predicted to decrease the exposure to Tivozanib. Manufacturer advises caution. |
| Tofacitinib | SEVERE | Phenytoin is predicted to decrease the exposure to Tofacitinib. Manufacturer advises avoid. |
| Tolvaptan | SEVERE | Phenytoin is predicted to decrease the exposure to Tolvaptan. Manufacturer advises use with cauti... |
| Trabectedin | SEVERE | Phenytoin is predicted to decrease the exposure to Trabectedin. Manufacturer advises avoid. |
| Trastuzumab emtansine | SEVERE | Phenytoin is predicted to decrease the exposure to the cytotoxic component of Trastuzumab emtansi... |
| Tucatinib | SEVERE | Phenytoin is predicted to decrease the exposure to Tucatinib. Manufacturer advises avoid. |
| Ulipristal | SEVERE | Phenytoin decreases the efficacy of Ulipristal. Manufacturer advises avoid and for 4 weeks after ... |
| Valproate | SEVERE | Valproate affects the concentration of Phenytoin and Phenytoin decreases the concentration of Val... |
| Vanzacaftor | SEVERE | Phenytoin is predicted to decrease the exposure to Vanzacaftor. Manufacturer advises avoid. |
| Velpatasvir | SEVERE | Phenytoin is predicted to moderately decrease the exposure to Velpatasvir. Manufacturer advises a... |
| Vemurafenib | SEVERE | Phenytoin is predicted to decrease the exposure to Vemurafenib. Manufacturer advises avoid. |
| Venetoclax | SEVERE | Phenytoin is predicted to decrease the exposure to Venetoclax. Manufacturer advises avoid. |
| Verapamil | SEVERE | Verapamil potentially increases the concentration of Phenytoin and Phenytoin is predicted to decr... |
| Vinblastine | SEVERE | Phenytoin is predicted to decrease the exposure to Vinblastine. Manufacturer makes no recommendat... |
| Vincristine | SEVERE | Phenytoin is predicted to decrease the exposure to Vincristine. Manufacturer advises caution. |
| Vindesine | SEVERE | Phenytoin is predicted to decrease the exposure to Vindesine. Manufacturer makes no recommendation. |
| Vinorelbine | SEVERE | Phenytoin is predicted to decrease the exposure to Vinorelbine. Manufacturer advises use with cau... |
| Voclosporin | SEVERE | Phenytoin is predicted to decrease the exposure to Voclosporin. Manufacturer advises avoid. |
| Vorasidenib | SEVERE | Phenytoin is predicted to decrease the exposure to Vorasidenib. Manufacturer advises avoid. |
| Voxilaprevir | SEVERE | Phenytoin is predicted to decrease the concentration of Voxilaprevir. Manufacturer advises avoid. |
| Zanubrutinib | SEVERE | Phenytoin is predicted to decrease the exposure to Zanubrutinib. Manufacturer advises avoid. |
| Abacavir | MODERATE | Phenytoin is predicted to decrease the exposure to Abacavir. Manufacturer makes no recommendation. |
| Abrocitinib | MODERATE | Phenytoin is predicted to decrease the exposure to Abrocitinib. Manufacturer advises avoid. |
| Acenocoumarol | MODERATE | Phenytoin is predicted to alter the anticoagulant effect of Acenocoumarol. Manufacturer makes no ... |
| Afatinib | MODERATE | Phenytoin is predicted to decrease the exposure to Afatinib. Manufacturer advises caution. |
| Agomelatine | MODERATE | Phenytoin is predicted to decrease the exposure to Agomelatine. Manufacturer makes no recommendat... |
| Albendazole | MODERATE | Phenytoin decreases the concentration of Albendazole. Manufacturer makes no recommendation. |
| Alfacalcidol | MODERATE | Phenytoin decreases the effects of Alfacalcidol. Manufacturer makes no recommendation. |
| Alfentanil | MODERATE | Phenytoin is predicted to decrease the exposure to Alfentanil. Manufacturer makes no recommendation. |
| Alpelisib | MODERATE | Phenytoin is predicted to decrease the exposure to Alpelisib. Manufacturer advises avoid. |
| Alprazolam | MODERATE | Phenytoin is predicted to decrease the exposure to Alprazolam. Manufacturer advises adjust dose. |
| Aminophylline | MODERATE | Phenytoin decreases the exposure to Aminophylline. Manufacturer advises adjust dose. |
| Amlodipine | MODERATE | Phenytoin is predicted to decrease the exposure to Amlodipine. Manufacturer advises monitor and a... |
| Aprepitant | MODERATE | Phenytoin is predicted to markedly decrease the exposure to Aprepitant. Manufacturer advises avoid. |
| Aripiprazole | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Aripiprazole. Manufacturer advises ... |
| Atorvastatin | MODERATE | Phenytoin moderately decreases the exposure to Atorvastatin. Manufacturer makes no recommendation. |
| Atracurium | MODERATE | Phenytoin decreases the effects of (but acute use increases the effects of) Atracurium. Manufactu... |
| Axitinib | MODERATE | Phenytoin is predicted to decrease the exposure to Axitinib. Manufacturer advises avoid or adjust... |
| Bazedoxifene | MODERATE | Phenytoin is predicted to decrease the exposure to Bazedoxifene. Manufacturer makes no recommenda... |
| Bictegravir | MODERATE | Phenytoin is predicted to decrease the exposure to Bictegravir. Manufacturer advises avoid. |
| Brivaracetam | MODERATE | Phenytoin decreases the concentration of Brivaracetam. Manufacturer makes no recommendation. |
| Budesonide | MODERATE | Phenytoin is predicted to decrease the exposure to Budesonide. Manufacturer advises monitor and a... |
| Buprenorphine | MODERATE | Phenytoin is predicted to decrease the exposure to Buprenorphine. Manufacturer advises monitor an... |
| Cabazitaxel | MODERATE | Phenytoin is predicted to decrease the exposure to Cabazitaxel. Manufacturer advises avoid. |
| Cabozantinib | MODERATE | Phenytoin moderately decreases the exposure to Cabozantinib. Manufacturer advises avoid. |
| Caffeine citrate | MODERATE | Phenytoin is predicted to moderately increase the clearance of Caffeine citrate. Manufacturer adv... |
| Calcifediol | MODERATE | Phenytoin decreases the effects of Calcifediol. Manufacturer makes no recommendation. |
| Calcipotriol | MODERATE | Phenytoin decreases the effects of Calcipotriol. Manufacturer makes no recommendation. |
| Calcitriol | MODERATE | Phenytoin decreases the effects of Calcitriol. Manufacturer makes no recommendation. |
| Canagliflozin | MODERATE | Phenytoin is predicted to decrease the exposure to Canagliflozin. Manufacturer advises adjust Can... |
| Cannabidiol | MODERATE | Phenytoin is predicted to decrease the exposure to Cannabidiol. Manufacturer advises adjust dose. |
| Capivasertib | MODERATE | Phenytoin is predicted to decrease the exposure to Capivasertib. Manufacturer advises avoid. |
| Caspofungin | MODERATE | Phenytoin is predicted to decrease the concentration of Caspofungin. Manufacturer advises adjust ... |
| Cenobamate | MODERATE | Cenobamate slightly increases the exposure to Phenytoin. Manufacturer advises monitor and adjust ... |
| Cilostazol | MODERATE | Phenytoin is predicted to alter the effects of Cilostazol. Manufacturer advises monitor antiplate... |
| Cinacalcet | MODERATE | Phenytoin is predicted to decrease the exposure to Cinacalcet. Manufacturer advises monitor and a... |
| Cisatracurium | MODERATE | Phenytoin decreases the effects of (but acute use increases the effects of) Cisatracurium. Manufa... |
| Clomethiazole | MODERATE | Phenytoin decreases the exposure to Clomethiazole. Manufacturer advises monitor and adjust dose. |
| Clozapine | MODERATE | Phenytoin is predicted to decrease the exposure to Clozapine. Manufacturer advises caution. |
| Colecalciferol | MODERATE | Phenytoin decreases the effects of Colecalciferol. Manufacturer makes no recommendation. |
| Dabrafenib | MODERATE | Phenytoin is predicted to decrease the exposure to Dabrafenib. Manufacturer advises avoid. |
| Darifenacin | MODERATE | Phenytoin is predicted to decrease the exposure to Darifenacin. Manufacturer makes no recommendat... |
| Darolutamide | MODERATE | Phenytoin is predicted to decrease the exposure to Darolutamide. Manufacturer advises avoid. |
| Deferasirox | MODERATE | Phenytoin is predicted to decrease the exposure to Deferasirox. Manufacturer advises monitor seru... |
| Deflazacort | MODERATE | Phenytoin is predicted to decrease the exposure to Deflazacort. Manufacturer advises monitor and ... |
| Delamanid | MODERATE | Phenytoin is predicted to slightly decrease the exposure to Delamanid. Manufacturer advises avoid. |
| Dexamethasone | MODERATE | Phenytoin is predicted to decrease the exposure to Dexamethasone. Manufacturer advises monitor an... |
| Diazoxide | MODERATE | Diazoxide decreases the concentration of Phenytoin and Phenytoin is predicted to decrease the eff... |
| Digoxin | MODERATE | Phenytoin is predicted to decrease the concentration of Digoxin. Manufacturer makes no recommenda... |
| Doxycycline | MODERATE | Phenytoin decreases the concentration of Doxycycline. Manufacturer advises adjust dose. |
| Duloxetine | MODERATE | Phenytoin is predicted to decrease the exposure to Duloxetine. Manufacturer makes no recommendation. |
| Elranatamab | MODERATE | Elranatamab might affect the exposure to Phenytoin. Manufacturer advises monitor and adjust dose. |
| Empagliflozin | MODERATE | Phenytoin might decrease the exposure to Empagliflozin. Manufacturer advises avoid or monitor dia... |
| Enfortumab vedotin | MODERATE | Phenytoin is predicted to decrease the exposure to the cytotoxic component of Enfortumab vedotin.... |
| Eplerenone | MODERATE | Phenytoin is predicted to decrease the exposure to Eplerenone. Manufacturer advises avoid. |
| Eravacycline | MODERATE | Phenytoin is predicted to decrease the exposure to Eravacycline. Manufacturer advises adjust Erav... |
| Ergocalciferol | MODERATE | Phenytoin decreases the effects of Ergocalciferol. Manufacturer makes no recommendation. |
| Esketamine | MODERATE | Phenytoin is predicted to decrease the exposure to Esketamine. Manufacturer advises adjust dose. |
| Eslicarbazepine | MODERATE | Eslicarbazepine increases the exposure to Phenytoin and Phenytoin decreases the exposure to Eslic... |
| Estradiol | MODERATE | Phenytoin is predicted to decrease the efficacy of Estradiol. Manufacturer makes no recommendation. |
| Eszopiclone | MODERATE | Phenytoin is predicted to decrease the exposure to Eszopiclone. Manufacturer advises adjust dose. |
| Etoposide | MODERATE | Phenytoin is predicted to decrease the efficacy of Etoposide. Manufacturer makes no recommendation. |
| Exemestane | MODERATE | Phenytoin moderately decreases the exposure to Exemestane. Manufacturer advises caution. |
| Fedratinib | MODERATE | Phenytoin is predicted to decrease the exposure to Fedratinib. Manufacturer advises avoid. |
| Felodipine | MODERATE | Phenytoin is predicted to decrease the exposure to Felodipine. Manufacturer advises monitor and a... |
| Fenfluramine | MODERATE | Phenytoin is predicted to decrease the exposure to Fenfluramine. Manufacturer makes no recommenda... |
| Fentanyl | MODERATE | Phenytoin is predicted to decrease the exposure to Fentanyl. Manufacturer advises caution. |
| Fesoterodine | MODERATE | Phenytoin is predicted to decrease the exposure to Fesoterodine. Manufacturer advises avoid. |
| Fluconazole | MODERATE | Fluconazole increases the concentration of Phenytoin. Manufacturer advises monitor concentration ... |
| Fludrocortisone | MODERATE | Phenytoin is predicted to decrease the exposure to Fludrocortisone. Manufacturer advises monitor ... |
| Fosaprepitant | MODERATE | Phenytoin is predicted to decrease the exposure to Fosaprepitant. Manufacturer advises avoid. |
| Foslevodopa | MODERATE | Phenytoin might decrease the effects of Foslevodopa. Manufacturer advises monitor. |
| Fruquintinib | MODERATE | Phenytoin is predicted to decrease the exposure to Fruquintinib. Manufacturer advises avoid. |
| Furosemide | MODERATE | Phenytoin decreases the effects of Furosemide. Manufacturer makes no recommendation. |
| Guanfacine | MODERATE | Phenytoin is predicted to decrease the concentration of Guanfacine. Manufacturer advises adjust G... |
| Haloperidol | MODERATE | Phenytoin decreases the concentration of Haloperidol. Manufacturer advises adjust dose. |
| Hormone replacement therapy | MODERATE | Phenytoin is predicted to decrease the effects of Hormone replacement therapy. Manufacturer advis... |
| Hydrocortisone | MODERATE | Phenytoin is predicted to decrease the exposure to Hydrocortisone. Manufacturer advises monitor a... |
| Imatinib | MODERATE | Phenytoin is predicted to decrease the exposure to Imatinib. Manufacturer advises avoid. |
| Isoniazid | MODERATE | Isoniazid increases the concentration of Phenytoin. Manufacturer advises monitor concentration. |
| Itraconazole | MODERATE | Phenytoin very markedly decreases the exposure to Itraconazole. Manufacturer advises avoid and fo... |
| Ivabradine | MODERATE | Phenytoin is predicted to decrease the exposure to Ivabradine. Manufacturer advises adjust dose. |
| Ketamine | MODERATE | Phenytoin is predicted to decrease the exposure to Ketamine. Manufacturer advises adjust dose. |
| Ketoconazole | MODERATE | Phenytoin decreases the exposure to Ketoconazole. Manufacturer advises avoid. |
| Lacidipine | MODERATE | Phenytoin is predicted to decrease the exposure to Lacidipine. Manufacturer advises monitor and a... |
| Lamotrigine | MODERATE | Phenytoin decreases the concentration of Lamotrigine. Manufacturer advises monitor and adjust Lam... |
| Larotrectinib | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Larotrectinib. Manufacturer advises... |
| Lercanidipine | MODERATE | Phenytoin is predicted to decrease the exposure to Lercanidipine. Manufacturer advises monitor an... |
| Letermovir | MODERATE | Letermovir is predicted to decrease the concentration of Phenytoin and Phenytoin is predicted to ... |
| Levodopa | MODERATE | Phenytoin decreases the effects of Levodopa. Manufacturer advises monitor worsening parkinsonian ... |
| Levothyroxine | MODERATE | Phenytoin is predicted to increase the risk of hypothyroidism when given with Levothyroxine. Manu... |
| Linagliptin | MODERATE | Phenytoin is predicted to decrease the exposure to Linagliptin. Manufacturer makes no recommendat... |
| Liothyronine | MODERATE | Phenytoin is predicted to increase the risk of hypothyroidism when given with Liothyronine. Manuf... |
| Lomitapide | MODERATE | Phenytoin is predicted to decrease the exposure to Lomitapide. Manufacturer advises monitor and a... |
| Lurasidone | MODERATE | Phenytoin is predicted to decrease the exposure to Lurasidone. Manufacturer advises avoid. |
| Melatonin | MODERATE | Phenytoin is predicted to decrease the exposure to Melatonin. Manufacturer advises caution. |
| Methylprednisolone | MODERATE | Phenytoin is predicted to decrease the exposure to Methylprednisolone. Manufacturer advises monit... |
| Metyrapone | MODERATE | Phenytoin is predicted to decrease the effects of Metyrapone. Manufacturer advises avoid. |
| Mexiletine | MODERATE | Phenytoin is predicted to increase the clearance of Mexiletine. Manufacturer advises monitor and ... |
| Mirtazapine | MODERATE | Phenytoin is predicted to decrease the exposure to Mirtazapine. Manufacturer advises adjust dose. |
| Modafinil | MODERATE | Phenytoin is predicted to decrease the exposure to Modafinil and Modafinil is predicted to increa... |
| Naloxegol | MODERATE | Phenytoin is predicted to markedly decrease the exposure to Naloxegol. Manufacturer advises avoid. |
| Nicardipine | MODERATE | Phenytoin is predicted to decrease the exposure to Nicardipine. Manufacturer advises monitor and ... |
| Nifedipine | MODERATE | Phenytoin is predicted to decrease the exposure to Nifedipine. Manufacturer advises monitor and a... |
| Nimodipine | MODERATE | Phenytoin is predicted to decrease the exposure to Nimodipine. Manufacturer advises monitor and a... |
| Nitisinone | MODERATE | Phenytoin is predicted to decrease the exposure to Nitisinone. Manufacturer advises adjust dose. |
| Olanzapine | MODERATE | Phenytoin is predicted to decrease the exposure to Olanzapine. Manufacturer advises monitor and a... |
| Olaparib | MODERATE | Phenytoin is predicted to decrease the exposure to Olaparib. Manufacturer advises avoid. |
| Ondansetron | MODERATE | Phenytoin is predicted to decrease the exposure to Ondansetron. Manufacturer makes no recommendat... |
| Osilodrostat | MODERATE | Phenytoin is predicted to decrease the exposure to Osilodrostat. Manufacturer advises caution and... |
| Osimertinib | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Osimertinib. Manufacturer advises a... |
| Ospemifene | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Ospemifene. Manufacturer makes no r... |
| Oxcarbazepine | MODERATE | Oxcarbazepine is predicted to increase the concentration of Phenytoin. Manufacturer advises monit... |
| Oxycodone | MODERATE | Phenytoin is predicted to decrease the exposure to Oxycodone. Manufacturer advises monitor and ad... |
| Pancuronium | MODERATE | Phenytoin decreases the effects of (but acute use increases the effects of) Pancuronium. Manufact... |
| Panobinostat | MODERATE | Phenytoin is predicted to decrease the exposure to Panobinostat. Manufacturer advises avoid. |
| Paracetamol | MODERATE | Phenytoin decreases the exposure to Paracetamol. Manufacturer makes no recommendation. |
| Paricalcitol | MODERATE | Phenytoin decreases the effects of Paricalcitol. Manufacturer makes no recommendation. |
| Paroxetine | MODERATE | Phenytoin decreases the concentration of Paroxetine. Manufacturer makes no recommendation. |
| Perampanel | MODERATE | Phenytoin is predicted to decrease the exposure to Perampanel. Manufacturer advises monitor and a... |
| Phenobarbital | MODERATE | Phenytoin increases the concentration of Phenobarbital and Phenobarbital affects the concentratio... |
| Piperaquine | MODERATE | Phenytoin is predicted to decrease the concentration of Piperaquine. Manufacturer advises avoid. |
| Pirfenidone | MODERATE | Phenytoin is predicted to decrease the exposure to Pirfenidone. Manufacturer makes no recommendat... |
| Pirtobrutinib | MODERATE | Phenytoin is predicted to decrease the exposure to Pirtobrutinib. Manufacturer advises avoid. |
| Pitolisant | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Pitolisant. Manufacturer advises ca... |
| Polatuzumab vedotin | MODERATE | Phenytoin is predicted to decrease the exposure to Polatuzumab vedotin. Manufacturer makes no rec... |
| Ponatinib | MODERATE | Phenytoin is predicted to decrease the exposure to Ponatinib. Manufacturer advises avoid. |
| Posaconazole | MODERATE | Phenytoin is predicted to decrease the exposure to Posaconazole. Manufacturer advises avoid. |
| Pralsetinib | MODERATE | Phenytoin is predicted to decrease the exposure to Pralsetinib. Manufacturer advises avoid or adj... |
| Praziquantel | MODERATE | Phenytoin is predicted to markedly decrease the exposure to Praziquantel. Manufacturer advises av... |
| Prednisolone | MODERATE | Phenytoin is predicted to decrease the exposure to Prednisolone. Manufacturer advises monitor and... |
| Primidone | MODERATE | Phenytoin increases the concentration of Primidone and Primidone affects the concentration of Phe... |
| Propafenone | MODERATE | Phenytoin is predicted to decrease the efficacy of Propafenone. Manufacturer advises monitor. |
| Quetiapine | MODERATE | Phenytoin is predicted to decrease the exposure to Quetiapine. Manufacturer advises consider alte... |
| Raltegravir | MODERATE | Phenytoin is predicted to affect the exposure to Raltegravir. Manufacturer advises use with cauti... |
| Reboxetine | MODERATE | Phenytoin is predicted to decrease the exposure to Reboxetine. Manufacturer makes no recommendation. |
| Regorafenib | MODERATE | Phenytoin is predicted to decrease the exposure to Regorafenib. Manufacturer advises avoid. |
| Relugolix | MODERATE | Phenytoin is predicted to decrease the exposure to Relugolix. Manufacturer advises avoid or adjus... |
| Repaglinide | MODERATE | Phenytoin is predicted to decrease the exposure to Repaglinide. Manufacturer advises monitor bloo... |
| Retigabine | MODERATE | Phenytoin is predicted to slightly increase the clearance of Retigabine. Manufacturer makes no re... |
| Rifampicin | MODERATE | Rifampicin decreases the concentration of Phenytoin. Manufacturer advises use with caution and ad... |
| Rimegepant | MODERATE | Phenytoin is predicted to decrease the exposure to Rimegepant. Manufacturer advises avoid. |
| Risperidone | MODERATE | Phenytoin is predicted to decrease the exposure to Risperidone. Manufacturer advises adjust dose. |
| Rocuronium | MODERATE | Phenytoin decreases the effects of (but acute use increases the effects of) Rocuronium. Manufactu... |
| Roflumilast | MODERATE | Phenytoin is predicted to decrease the exposure to Roflumilast. Manufacturer advises avoid. |
| Ropivacaine | MODERATE | Phenytoin is predicted to decrease the exposure to Ropivacaine. Manufacturer makes no recommendat... |
| Rucaparib | MODERATE | Rucaparib is predicted to increase the exposure to Phenytoin. Manufacturer advises monitor and ad... |
| Ruxolitinib | MODERATE | Phenytoin is predicted to decrease the exposure to Ruxolitinib. Manufacturer advises monitor and ... |
| Saxagliptin | MODERATE | Phenytoin is predicted to moderately decrease the exposure to Saxagliptin. Manufacturer advises m... |
| Selexipag | MODERATE | Phenytoin is predicted to decrease the exposure to the active metabolite of Selexipag. Manufactur... |
| Selpercatinib | MODERATE | Phenytoin is predicted to decrease the exposure to Selpercatinib. Manufacturer advises avoid. |
| Sildenafil | MODERATE | Phenytoin is predicted to decrease the exposure to Sildenafil. Manufacturer advises monitor effic... |
| Simvastatin | MODERATE | Phenytoin is predicted to decrease the exposure to Simvastatin. Manufacturer makes no recommendat... |
| Solifenacin | MODERATE | Phenytoin is predicted to decrease the exposure to Solifenacin. Manufacturer makes no recommendat... |
| Sorafenib | MODERATE | Phenytoin is predicted to decrease the exposure to Sorafenib. Manufacturer makes no recommendation. |
| Sulfadiazine | MODERATE | Sulfadiazine increases the concentration of Phenytoin. Manufacturer advises monitor and adjust dose. |
| Sunitinib | MODERATE | Phenytoin is predicted to decrease the exposure to Sunitinib. Manufacturer advises avoid or adjus... |
| Suxamethonium | MODERATE | Phenytoin increases the effects of Suxamethonium. Manufacturer makes no recommendation. |
| Tacalcitol | MODERATE | Phenytoin decreases the effects of Tacalcitol. Manufacturer makes no recommendation. |
| Tenofovir alafenamide | MODERATE | Phenytoin is predicted to decrease the exposure to Tenofovir alafenamide. Manufacturer advises av... |
| Theophylline | MODERATE | Phenytoin is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust dose. |
| Tiagabine | MODERATE | Phenytoin decreases the exposure to Tiagabine. Manufacturer advises monitor and adjust Tiagabine ... |
| Tocilizumab | MODERATE | Tocilizumab is predicted to decrease the exposure to Phenytoin. Manufacturer advises monitor and ... |
| Topiramate | MODERATE | Phenytoin decreases the concentration of Topiramate and Topiramate increases the concentration of... |
| Topotecan | MODERATE | Phenytoin increases the clearance of Topotecan. Manufacturer makes no recommendation. |
| Toremifene | MODERATE | Phenytoin is predicted to decrease the exposure to Toremifene. Manufacturer advises adjust dose. |
| Triamcinolone | MODERATE | Phenytoin is predicted to decrease the exposure to Triamcinolone. Manufacturer advises monitor an... |
| Trimethoprim | MODERATE | Trimethoprim increases the concentration of Phenytoin. Manufacturer advises monitor concentration. |
| Upadacitinib | MODERATE | Phenytoin is predicted to decrease the exposure to Upadacitinib. Manufacturer advises monitor eff... |
| Vandetanib | MODERATE | Phenytoin is predicted to decrease the exposure to Vandetanib. Manufacturer advises avoid. |
| Vardenafil | MODERATE | Phenytoin is predicted to decrease the exposure to Vardenafil. Manufacturer makes no recommendation. |
| Vecuronium | MODERATE | Phenytoin decreases the effects of (but acute use increases the effects of) Vecuronium. Manufactu... |
| Vismodegib | MODERATE | Phenytoin is predicted to decrease the exposure to Vismodegib. Manufacturer advises avoid. |
| Voriconazole | MODERATE | Phenytoin decreases the exposure to Voriconazole and Voriconazole increases the exposure to Pheny... |
| Vortioxetine | MODERATE | Phenytoin is predicted to decrease the exposure to Vortioxetine. Manufacturer advises monitor and... |
| Warfarin | MODERATE | Phenytoin is predicted to alter the anticoagulant effect of Warfarin. Manufacturer makes no recom... |
| Zonisamide | MODERATE | Phenytoin slightly to moderately decreases the concentration of Zonisamide. Manufacturer advises ... |
| Zopiclone | MODERATE | Phenytoin is predicted to decrease the exposure to Zopiclone. Manufacturer advises adjust dose. |
| Donepezil | MILD | Phenytoin is predicted to decrease the exposure to Donepezil. Manufacturer advises caution. |
| Dronabinol | MILD | Phenytoin is predicted to decrease the exposure to Dronabinol. Manufacturer advises avoid or adju... |
| Montelukast | MILD | Phenytoin is predicted to decrease the exposure to Montelukast. Manufacturer advises caution. |
| Tizanidine | MILD | Phenytoin moderately decreases the exposure to Tizanidine. Manufacturer makes no recommendation. |
| Treprostinil | MILD | Phenytoin is predicted to decrease the exposure to Treprostinil. Manufacturer advises adjust dose. |
| Vigabatrin | MILD | Vigabatrin decreases the concentration of Phenytoin. Manufacturer advises monitor concentration. |
| Alcohol | LOW | Both Phenytoin and Alcohol have effects on the CNS and can cause sedation, which might affect the... |
| Alimemazine | LOW | Both Phenytoin and Alimemazine have effects on the CNS and can cause sedation, which might affect... |
| Amisulpride | LOW | Both Phenytoin and Amisulpride have effects on the CNS and can cause sedation, which might affect... |
| Amitriptyline | LOW | Both Phenytoin and Amitriptyline have effects on the CNS and can cause sedation, which might affe... |
| Apomorphine | LOW | Both Phenytoin and Apomorphine have effects on the CNS and can cause sedation, which might affect... |
| Apraclonidine | LOW | Both Phenytoin and Apraclonidine have effects on the CNS and can cause sedation, which might affe... |
| Asenapine | LOW | Both Phenytoin and Asenapine have effects on the CNS and can cause sedation, which might affect t... |
| Baclofen | LOW | Both Phenytoin and Baclofen have effects on the CNS and can cause sedation, which might affect th... |
| Benperidol | LOW | Both Phenytoin and Benperidol have effects on the CNS and can cause sedation, which might affect ... |
| Brentuximab vedotin | LOW | Both Phenytoin and Brentuximab vedotin can increase the risk of peripheral neuropathy. |
| Brimonidine | LOW | Both Phenytoin and Brimonidine have effects on the CNS and can cause sedation, which might affect... |
| Bromocriptine | LOW | Both Phenytoin and Bromocriptine have effects on the CNS and can cause sedation, which might affe... |
| Buclizine | LOW | Both Phenytoin and Buclizine have effects on the CNS and can cause sedation, which might affect t... |
| Cabergoline | LOW | Both Phenytoin and Cabergoline have effects on the CNS and can cause sedation, which might affect... |
| Carboplatin | LOW | Both Phenytoin and Carboplatin can increase the risk of peripheral neuropathy. |
| Chloral hydrate | LOW | Both Phenytoin and Chloral hydrate have effects on the CNS and can cause sedation, which might af... |
| Chlorphenamine | LOW | Both Phenytoin and Chlorphenamine have effects on the CNS and can cause sedation, which might aff... |
| Chlorpromazine | LOW | Both Phenytoin and Chlorpromazine have effects on the CNS and can cause sedation, which might aff... |
| Cinnarizine | LOW | Both Phenytoin and Cinnarizine have effects on the CNS and can cause sedation, which might affect... |
| Cisplatin | LOW | Both Phenytoin and Cisplatin can increase the risk of peripheral neuropathy. |
| Citalopram | LOW | Both Phenytoin and Citalopram have effects on the CNS and can cause sedation, which might affect ... |
| Clomipramine | LOW | Both Phenytoin and Clomipramine have effects on the CNS and can cause sedation, which might affec... |
| Clonidine | LOW | Both Phenytoin and Clonidine have effects on the CNS and can cause sedation, which might affect t... |
| Codeine | LOW | Both Phenytoin and Codeine have effects on the CNS and can cause sedation, which might affect the... |
| Cyclizine | LOW | Both Phenytoin and Cyclizine have effects on the CNS and can cause sedation, which might affect t... |
| Cyproheptadine | LOW | Both Phenytoin and Cyproheptadine have effects on the CNS and can cause sedation, which might aff... |
| Cytarabine | LOW | Both Phenytoin and Cytarabine can increase the risk of peripheral neuropathy. |
| Dapoxetine | LOW | Both Phenytoin and Dapoxetine have effects on the CNS and can cause sedation, which might affect ... |
| Desflurane | LOW | Both Phenytoin and Desflurane have effects on the CNS and can cause sedation, which might affect ... |
| Dexmedetomidine | LOW | Both Phenytoin and Dexmedetomidine have effects on the CNS and can cause sedation, which might af... |
| Diamorphine | LOW | Both Phenytoin and Diamorphine have effects on the CNS and can cause sedation, which might affect... |
| Difelikefalin | LOW | Both Phenytoin and Difelikefalin have effects on the CNS and can cause sedation, which might affe... |
| Dihydrocodeine | LOW | Both Phenytoin and Dihydrocodeine have effects on the CNS and can cause sedation, which might aff... |
| Dimenhydrinate | LOW | Both Phenytoin and Dimenhydrinate have effects on the CNS and can cause sedation, which might aff... |
| Dipipanone | LOW | Both Phenytoin and Dipipanone have effects on the CNS and can cause sedation, which might affect ... |
| Dosulepin | LOW | Both Phenytoin and Dosulepin have effects on the CNS and can cause sedation, which might affect t... |
| Doxepin | LOW | Both Phenytoin and Doxepin have effects on the CNS and can cause sedation, which might affect the... |
| Doxylamine | LOW | Both Phenytoin and Doxylamine have effects on the CNS and can cause sedation, which might affect ... |
| Droperidol | LOW | Both Phenytoin and Droperidol have effects on the CNS and can cause sedation, which might affect ... |
| Enfuvirtide | LOW | Both Phenytoin and Enfuvirtide can increase the risk of peripheral neuropathy. |
| Eribulin | LOW | Both Phenytoin and Eribulin can increase the risk of peripheral neuropathy. |
| Escitalopram | LOW | Both Phenytoin and Escitalopram have effects on the CNS and can cause sedation, which might affec... |
| Etomidate | LOW | Both Phenytoin and Etomidate have effects on the CNS and can cause sedation, which might affect t... |
| Flupentixol | LOW | Both Phenytoin and Flupentixol have effects on the CNS and can cause sedation, which might affect... |
| Flurazepam | LOW | Both Phenytoin and Flurazepam have effects on the CNS and can cause sedation, which might affect ... |
| Hydromorphone | LOW | Both Phenytoin and Hydromorphone have effects on the CNS and can cause sedation, which might affe... |
| Hydroxyzine | LOW | Both Phenytoin and Hydroxyzine have effects on the CNS and can cause sedation, which might affect... |
| Imipramine | LOW | Both Phenytoin and Imipramine have effects on the CNS and can cause sedation, which might affect ... |
| Isoflurane | LOW | Both Phenytoin and Isoflurane have effects on the CNS and can cause sedation, which might affect ... |
| Ketotifen | LOW | Both Phenytoin and Ketotifen have effects on the CNS and can cause sedation, which might affect t... |
| Lamivudine | LOW | Both Phenytoin and Lamivudine can increase the risk of peripheral neuropathy. |
| Leflunomide | LOW | Both Phenytoin and Leflunomide can increase the risk of peripheral neuropathy. |
| Lenalidomide | LOW | Both Phenytoin and Lenalidomide can increase the risk of peripheral neuropathy. |
| Levomepromazine | LOW | Both Phenytoin and Levomepromazine have effects on the CNS and can cause sedation, which might af... |
| Lofepramine | LOW | Both Phenytoin and Lofepramine have effects on the CNS and can cause sedation, which might affect... |
| Lofexidine | LOW | Both Phenytoin and Lofexidine have effects on the CNS and can cause sedation, which might affect ... |
| Loprazolam | LOW | Both Phenytoin and Loprazolam have effects on the CNS and can cause sedation, which might affect ... |
| Lorazepam | LOW | Both Phenytoin and Lorazepam have effects on the CNS and can cause sedation, which might affect t... |
| Lormetazepam | LOW | Both Phenytoin and Lormetazepam have effects on the CNS and can cause sedation, which might affec... |
| Loxapine | LOW | Both Phenytoin and Loxapine have effects on the CNS and can cause sedation, which might affect th... |
| Meptazinol | LOW | Both Phenytoin and Meptazinol have effects on the CNS and can cause sedation, which might affect ... |
| Methocarbamol | LOW | Both Phenytoin and Methocarbamol have effects on the CNS and can cause sedation, which might affe... |
| Methoxyflurane | LOW | Both Phenytoin and Methoxyflurane have effects on the CNS and can cause sedation, which might aff... |
| Metronidazole | LOW | Both Phenytoin and Metronidazole can increase the risk of peripheral neuropathy. |
| Mianserin | LOW | Both Phenytoin and Mianserin have effects on the CNS and can cause sedation, which might affect t... |
| Morphine | LOW | Both Phenytoin and Morphine have effects on the CNS and can cause sedation, which might affect th... |
| Moxonidine | LOW | Both Phenytoin and Moxonidine have effects on the CNS and can cause sedation, which might affect ... |
| Nabilone | LOW | Both Phenytoin and Nabilone have effects on the CNS and can cause sedation, which might affect th... |
| Nitrazepam | LOW | Both Phenytoin and Nitrazepam have effects on the CNS and can cause sedation, which might affect ... |
| Nitrofurantoin | LOW | Both Phenytoin and Nitrofurantoin can increase the risk of peripheral neuropathy. |
| Nitrous oxide | LOW | Both Phenytoin and Nitrous oxide have effects on the CNS and can cause sedation, which might affe... |
| Nortriptyline | LOW | Both Phenytoin and Nortriptyline have effects on the CNS and can cause sedation, which might affe... |
| Orphenadrine | LOW | Both Phenytoin and Orphenadrine have effects on the CNS and can cause sedation, which might affec... |
| Oxaliplatin | LOW | Both Phenytoin and Oxaliplatin can increase the risk of peripheral neuropathy. |
| Oxazepam | LOW | Both Phenytoin and Oxazepam have effects on the CNS and can cause sedation, which might affect th... |
| Pentazocine | LOW | Both Phenytoin and Pentazocine have effects on the CNS and can cause sedation, which might affect... |
| Pericyazine | LOW | Both Phenytoin and Pericyazine have effects on the CNS and can cause sedation, which might affect... |
| Pethidine | LOW | Both Phenytoin and Pethidine have effects on the CNS and can cause sedation, which might affect t... |
| Pimozide | LOW | Both Phenytoin and Pimozide have effects on the CNS and can cause sedation, which might affect th... |
| Pizotifen | LOW | Both Phenytoin and Pizotifen have effects on the CNS and can cause sedation, which might affect t... |
| Pomalidomide | LOW | Both Phenytoin and Pomalidomide can increase the risk of peripheral neuropathy. |
| Pramipexole | LOW | Both Phenytoin and Pramipexole have effects on the CNS and can cause sedation, which might affect... |
| Prochlorperazine | LOW | Both Phenytoin and Prochlorperazine have effects on the CNS and can cause sedation, which might a... |
| Procyclidine | LOW | Both Phenytoin and Procyclidine have effects on the CNS and can cause sedation, which might affec... |
| Promazine | LOW | Both Phenytoin and Promazine have effects on the CNS and can cause sedation, which might affect t... |
| Promethazine | LOW | Both Phenytoin and Promethazine have effects on the CNS and can cause sedation, which might affec... |
| Propofol | LOW | Both Phenytoin and Propofol have effects on the CNS and can cause sedation, which might affect th... |
| Quinagolide | LOW | Both Phenytoin and Quinagolide have effects on the CNS and can cause sedation, which might affect... |
| Remifentanil | LOW | Both Phenytoin and Remifentanil have effects on the CNS and can cause sedation, which might affec... |
| Remimazolam | LOW | Both Phenytoin and Remimazolam have effects on the CNS and can cause sedation, which might affect... |
| Ropinirole | LOW | Both Phenytoin and Ropinirole have effects on the CNS and can cause sedation, which might affect ... |
| Rotigotine | LOW | Both Phenytoin and Rotigotine have effects on the CNS and can cause sedation, which might affect ... |
| Sevoflurane | LOW | Both Phenytoin and Sevoflurane have effects on the CNS and can cause sedation, which might affect... |
| Sodium oxybate | LOW | Both Phenytoin and Sodium oxybate have effects on the CNS and can cause sedation, which might aff... |
| Sufentanil | LOW | Both Phenytoin and Sufentanil have effects on the CNS and can cause sedation, which might affect ... |
| Sulpiride | LOW | Both Phenytoin and Sulpiride have effects on the CNS and can cause sedation, which might affect t... |
| Tapentadol | LOW | Both Phenytoin and Tapentadol have effects on the CNS and can cause sedation, which might affect ... |
| Temazepam | LOW | Both Phenytoin and Temazepam have effects on the CNS and can cause sedation, which might affect t... |
| Teriflunomide | LOW | Both Phenytoin and Teriflunomide can increase the risk of peripheral neuropathy. |
| Tetrabenazine | LOW | Both Phenytoin and Tetrabenazine have effects on the CNS and can cause sedation, which might affe... |
| Thalidomide | LOW | Both Phenytoin and Thalidomide can increase the risk of peripheral neuropathy. |
| Thiopental | LOW | Both Phenytoin and Thiopental have effects on the CNS and can cause sedation, which might affect ... |
| Tramadol | LOW | Both Phenytoin and Tramadol have effects on the CNS and can cause sedation, which might affect th... |
| Trazodone | LOW | Both Phenytoin and Trazodone have effects on the CNS and can cause sedation, which might affect t... |
| Trifluoperazine | LOW | Both Phenytoin and Trifluoperazine have effects on the CNS and can cause sedation, which might af... |
| Trihexyphenidyl | LOW | Both Phenytoin and Trihexyphenidyl have effects on the CNS and can cause sedation, which might af... |
| Trimipramine | LOW | Both Phenytoin and Trimipramine have effects on the CNS and can cause sedation, which might affec... |
| Venlafaxine | LOW | Both Phenytoin and Venlafaxine have effects on the CNS and can cause sedation, which might affect... |
| Zolpidem | LOW | Both Phenytoin and Zolpidem have effects on the CNS and can cause sedation, which might affect th... |
| Zuclopenthixol | LOW | Both Phenytoin and Zuclopenthixol have effects on the CNS and can cause sedation, which might aff... |
| Fluticasone | UNKNOWN | Phenytoin is predicted to decrease the exposure to Fluticasone. Manufacturer makes no recommendat... |
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