Rivaroxaban Drug Interactions
145Total Interactions
121Severe
24Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Acalabrutinib | SEVERE | Rivaroxaban causes bleeding, as can Acalabrutinib ; concurrent use might increase the risk of dev... |
| Aceclofenac | SEVERE | Rivaroxaban causes bleeding, as can Aceclofenac ; concurrent use might increase the risk of devel... |
| Acenocoumarol | SEVERE | Both Rivaroxaban and Acenocoumarol can increase the risk of bleeding. |
| Alprostadil | SEVERE | Rivaroxaban causes bleeding, as can Alprostadil ; concurrent use might increase the risk of devel... |
| Alteplase | SEVERE | Both Rivaroxaban and Alteplase can increase the risk of bleeding. |
| Anagrelide | SEVERE | Rivaroxaban causes bleeding, as can Anagrelide ; concurrent use might increase the risk of develo... |
| Argatroban | SEVERE | Both Rivaroxaban and Argatroban can increase the risk of bleeding. |
| Asparaginase | SEVERE | Both Rivaroxaban and Asparaginase can increase the risk of bleeding. |
| Aspirin | SEVERE | Rivaroxaban causes bleeding, as can Aspirin ; concurrent use might increase the risk of developin... |
| Atazanavir | SEVERE | Atazanavir boosted with ritonavir is predicted to increase the exposure to Rivaroxaban. Manufactu... |
| Avapritinib | SEVERE | Rivaroxaban might increase the risk of bleeding when given with Avapritinib. Manufacturer advises... |
| Axitinib | SEVERE | Rivaroxaban causes bleeding, as can Axitinib ; concurrent use might increase the risk of developi... |
| Bemiparin | SEVERE | Both Rivaroxaban and Bemiparin can increase the risk of bleeding. |
| Benzydamine | SEVERE | Rivaroxaban causes bleeding, as can Benzydamine ; concurrent use might increase the risk of devel... |
| Bevacizumab | SEVERE | Rivaroxaban causes bleeding, as can Bevacizumab ; concurrent use might increase the risk of devel... |
| Bivalirudin | SEVERE | Both Rivaroxaban and Bivalirudin can increase the risk of bleeding. |
| Bosutinib | SEVERE | Rivaroxaban causes bleeding, as can Bosutinib ; concurrent use might increase the risk of develop... |
| Bromfenac | SEVERE | Rivaroxaban causes bleeding, as can Bromfenac ; concurrent use might increase the risk of develop... |
| Cabozantinib | SEVERE | Rivaroxaban causes bleeding, as can Cabozantinib ; concurrent use might increase the risk of deve... |
| Cangrelor | SEVERE | Rivaroxaban causes bleeding, as can Cangrelor ; concurrent use might increase the risk of develop... |
| Caplacizumab | SEVERE | Rivaroxaban causes bleeding, as can Caplacizumab ; concurrent use might increase the risk of deve... |
| Carbamazepine | SEVERE | Carbamazepine is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid un... |
| Celecoxib | SEVERE | Rivaroxaban causes bleeding, as can Celecoxib ; concurrent use might increase the risk of develop... |
| Cilostazol | SEVERE | Rivaroxaban causes bleeding, as can Cilostazol ; concurrent use might increase the risk of develo... |
| Citalopram | SEVERE | Rivaroxaban causes bleeding, as can Citalopram ; concurrent use might increase the risk of develo... |
| Clopidogrel | SEVERE | Rivaroxaban causes bleeding, as can Clopidogrel ; concurrent use might increase the risk of devel... |
| Cobicistat | SEVERE | Cobicistat is predicted to increase the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Cobimetinib | SEVERE | Rivaroxaban causes bleeding, as can Cobimetinib ; concurrent use might increase the risk of devel... |
| Crisantaspase | SEVERE | Both Rivaroxaban and Crisantaspase can increase the risk of bleeding. |
| Dabigatran | SEVERE | Both Rivaroxaban and Dabigatran can increase the risk of bleeding. |
| Dalteparin | SEVERE | Both Rivaroxaban and Dalteparin can increase the risk of bleeding. |
| Danaparoid | SEVERE | Both Rivaroxaban and Danaparoid can increase the risk of bleeding. |
| Dapoxetine | SEVERE | Rivaroxaban causes bleeding, as can Dapoxetine ; concurrent use might increase the risk of develo... |
| Darunavir | SEVERE | Darunavir boosted with ritonavir is predicted to increase the exposure to Rivaroxaban. Manufactur... |
| Dasatinib | SEVERE | Rivaroxaban causes bleeding, as can Dasatinib ; concurrent use might increase the risk of develop... |
| Dexketoprofen | SEVERE | Rivaroxaban causes bleeding, as can Dexketoprofen ; concurrent use might increase the risk of dev... |
| Diclofenac | SEVERE | Rivaroxaban causes bleeding, as can Diclofenac ; concurrent use might increase the risk of develo... |
| Dipyridamole | SEVERE | Rivaroxaban causes bleeding, as can Dipyridamole ; concurrent use might increase the risk of deve... |
| Donanemab | SEVERE | Donanemab can increase the risk of brain haemorrhage when given with Rivaroxaban. Manufacturer ad... |
| Duloxetine | SEVERE | Rivaroxaban causes bleeding, as can Duloxetine ; concurrent use might increase the risk of develo... |
| Enoxaparin | SEVERE | Both Rivaroxaban and Enoxaparin can increase the risk of bleeding. |
| Epoprostenol | SEVERE | Rivaroxaban causes bleeding, as can Epoprostenol ; concurrent use might increase the risk of deve... |
| Eptifibatide | SEVERE | Both Rivaroxaban and Eptifibatide can increase the risk of bleeding. |
| Escitalopram | SEVERE | Rivaroxaban causes bleeding, as can Escitalopram ; concurrent use might increase the risk of deve... |
| Etodolac | SEVERE | Rivaroxaban causes bleeding, as can Etodolac ; concurrent use might increase the risk of developi... |
| Etoricoxib | SEVERE | Rivaroxaban causes bleeding, as can Etoricoxib ; concurrent use might increase the risk of develo... |
| Fluoxetine | SEVERE | Rivaroxaban causes bleeding, as can Fluoxetine ; concurrent use might increase the risk of develo... |
| Flurbiprofen | SEVERE | Rivaroxaban causes bleeding, as can Flurbiprofen ; concurrent use might increase the risk of deve... |
| Fluvoxamine | SEVERE | Rivaroxaban causes bleeding, as can Fluvoxamine ; concurrent use might increase the risk of devel... |
| Fosamprenavir | SEVERE | Fosamprenavir boosted with ritonavir is predicted to increase the exposure to Rivaroxaban. Manufa... |
| Fosphenytoin | SEVERE | Fosphenytoin is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unl... |
| Heparin | SEVERE | Both Rivaroxaban and Heparin can increase the risk of bleeding. |
| Ibrutinib | SEVERE | Rivaroxaban causes bleeding, as can Ibrutinib ; concurrent use might increase the risk of develop... |
| Ibuprofen | SEVERE | Rivaroxaban causes bleeding, as can Ibuprofen ; concurrent use might increase the risk of develop... |
| Icosapent | SEVERE | Rivaroxaban causes bleeding, as can Icosapent ; concurrent use might increase the risk of develop... |
| Iloprost | SEVERE | Rivaroxaban causes bleeding, as can Iloprost ; concurrent use might increase the risk of developi... |
| Imatinib | SEVERE | Rivaroxaban causes bleeding, as can Imatinib ; concurrent use might increase the risk of developi... |
| Indometacin | SEVERE | Rivaroxaban causes bleeding, as can Indometacin ; concurrent use might increase the risk of devel... |
| Inotersen | SEVERE | Rivaroxaban causes bleeding, as can Inotersen ; concurrent use might increase the risk of develop... |
| Ipilimumab | SEVERE | Rivaroxaban might increase the risk of gastrointestinal bleeding when given with Ipilimumab. Manu... |
| Itraconazole | SEVERE | Itraconazole is predicted to increase the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Ketoconazole | SEVERE | Ketoconazole moderately increases the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Ketoprofen | SEVERE | Rivaroxaban causes bleeding, as can Ketoprofen ; concurrent use might increase the risk of develo... |
| Ketorolac | SEVERE | Rivaroxaban causes bleeding, as can Ketorolac ; concurrent use might increase the risk of develop... |
| Lecanemab | SEVERE | Lecanemab can increase the risk of brain haemorrhage when given with Rivaroxaban. Manufacturer ad... |
| Lenacapavir | SEVERE | Lenacapavir is predicted to increase the concentration of Rivaroxaban. Manufacturer advises monit... |
| Lenvatinib | SEVERE | Rivaroxaban causes bleeding, as can Lenvatinib ; concurrent use might increase the risk of develo... |
| Lopinavir | SEVERE | Lopinavir boosted with ritonavir increases the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Lorlatinib | SEVERE | Lorlatinib is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unles... |
| Mefenamic acid | SEVERE | Rivaroxaban causes bleeding, as can Mefenamic acid ; concurrent use might increase the risk of de... |
| Meloxicam | SEVERE | Rivaroxaban causes bleeding, as can Meloxicam ; concurrent use might increase the risk of develop... |
| Nabumetone | SEVERE | Rivaroxaban causes bleeding, as can Nabumetone ; concurrent use might increase the risk of develo... |
| Naproxen | SEVERE | Rivaroxaban causes bleeding, as can Naproxen ; concurrent use might increase the risk of developi... |
| Nicotinic acid | SEVERE | Both Rivaroxaban and Nicotinic acid can increase the risk of bleeding. |
| Nintedanib | SEVERE | Rivaroxaban causes bleeding, as can Nintedanib ; concurrent use might increase the risk of develo... |
| Nirmatrelvir | SEVERE | Nirmatrelvir boosted with ritonavir is predicted to increase the concentration of Rivaroxaban. Ma... |
| Omega-3-acid ethyl esters | SEVERE | Rivaroxaban causes bleeding, as can Omega-3-acid ethyl esters ; concurrent use might increase the... |
| Oxcarbazepine | SEVERE | Oxcarbazepine decreases the exposure to Rivaroxaban. Manufacturer makes no recommendation. |
| Parecoxib | SEVERE | Rivaroxaban causes bleeding, as can Parecoxib ; concurrent use might increase the risk of develop... |
| Paroxetine | SEVERE | Rivaroxaban causes bleeding, as can Paroxetine ; concurrent use might increase the risk of develo... |
| Pazopanib | SEVERE | Rivaroxaban causes bleeding, as can Pazopanib ; concurrent use might increase the risk of develop... |
| Pegaspargase | SEVERE | Both Rivaroxaban and Pegaspargase can increase the risk of bleeding. |
| Pentosan | SEVERE | Both Rivaroxaban and Pentosan can increase the risk of bleeding. |
| Phenazone | SEVERE | Rivaroxaban causes bleeding, as can Phenazone ; concurrent use might increase the risk of develop... |
| Phenindione | SEVERE | Both Rivaroxaban and Phenindione can increase the risk of bleeding. |
| Phenobarbital | SEVERE | Phenobarbital decreases the exposure to Rivaroxaban. Manufacturer advises avoid unless patient ca... |
| Phenytoin | SEVERE | Phenytoin decreases the exposure to Rivaroxaban. Manufacturer advises avoid unless patient can be... |
| Piroxicam | SEVERE | Rivaroxaban causes bleeding, as can Piroxicam ; concurrent use might increase the risk of develop... |
| Ponatinib | SEVERE | Rivaroxaban causes bleeding, as can Ponatinib ; concurrent use might increase the risk of develop... |
| Posaconazole | SEVERE | Posaconazole is predicted to increase the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Prasugrel | SEVERE | Rivaroxaban causes bleeding, as can Prasugrel ; concurrent use might increase the risk of develop... |
| Primidone | SEVERE | Primidone decreases the exposure to Rivaroxaban. Manufacturer advises avoid unless patient can be... |
| Ranibizumab | SEVERE | Rivaroxaban causes bleeding, as can Ranibizumab ; concurrent use might increase the risk of devel... |
| Regorafenib | SEVERE | Rivaroxaban causes bleeding, as can Regorafenib ; concurrent use might increase the risk of devel... |
| Rifampicin | SEVERE | Rifampicin is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unles... |
| Ritonavir | SEVERE | Ritonavir moderately increases the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Ruxolitinib | SEVERE | Rivaroxaban causes bleeding, as can Ruxolitinib ; concurrent use might increase the risk of devel... |
| Sertraline | SEVERE | Rivaroxaban causes bleeding, as can Sertraline ; concurrent use might increase the risk of develo... |
| Sorafenib | SEVERE | Rivaroxaban causes bleeding, as can Sorafenib ; concurrent use might increase the risk of develop... |
| St John's wort | SEVERE | St John's wort is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid u... |
| Streptokinase | SEVERE | Both Rivaroxaban and Streptokinase can increase the risk of bleeding. |
| Sulindac | SEVERE | Rivaroxaban causes bleeding, as can Sulindac ; concurrent use might increase the risk of developi... |
| Sunitinib | SEVERE | Rivaroxaban causes bleeding, as can Sunitinib ; concurrent use might increase the risk of develop... |
| Tenecteplase | SEVERE | Both Rivaroxaban and Tenecteplase can increase the risk of bleeding. |
| Tenoxicam | SEVERE | Rivaroxaban causes bleeding, as can Tenoxicam ; concurrent use might increase the risk of develop... |
| Tiaprofenic acid | SEVERE | Rivaroxaban causes bleeding, as can Tiaprofenic acid ; concurrent use might increase the risk of ... |
| Ticagrelor | SEVERE | Rivaroxaban causes bleeding, as can Ticagrelor ; concurrent use might increase the risk of develo... |
| Tinzaparin | SEVERE | Both Rivaroxaban and Tinzaparin can increase the risk of bleeding. |
| Tirofiban | SEVERE | Both Rivaroxaban and Tirofiban can increase the risk of bleeding. |
| Tolfenamic acid | SEVERE | Rivaroxaban causes bleeding, as can Tolfenamic acid ; concurrent use might increase the risk of d... |
| Trametinib | SEVERE | Rivaroxaban causes bleeding, as can Trametinib ; concurrent use might increase the risk of develo... |
| Trastuzumab emtansine | SEVERE | Rivaroxaban causes bleeding, as can Trastuzumab emtansine ; concurrent use might increase the ris... |
| Treprostinil | SEVERE | Rivaroxaban causes bleeding, as can Treprostinil ; concurrent use might increase the risk of deve... |
| Urokinase | SEVERE | Both Rivaroxaban and Urokinase can increase the risk of bleeding. |
| Venetoclax | SEVERE | Venetoclax is predicted to increase the exposure to Rivaroxaban. Manufacturer advises avoid or ad... |
| Venlafaxine | SEVERE | Rivaroxaban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of devel... |
| Volanesorsen | SEVERE | Rivaroxaban causes bleeding, as can Volanesorsen ; concurrent use might increase the risk of deve... |
| Voriconazole | SEVERE | Voriconazole is predicted to increase the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Vortioxetine | SEVERE | Rivaroxaban causes bleeding, as can Vortioxetine ; concurrent use might increase the risk of deve... |
| Warfarin | SEVERE | Both Rivaroxaban and Warfarin can increase the risk of bleeding. |
| Zanubrutinib | SEVERE | Rivaroxaban causes bleeding, as can Zanubrutinib ; concurrent use might increase the risk of deve... |
| Amiodarone | MODERATE | Amiodarone might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impa... |
| Apalutamide | MODERATE | Apalutamide is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unle... |
| Azithromycin | MODERATE | Azithromycin is predicted to increase the exposure to Rivaroxaban. Manufacturer advises caution i... |
| Bismuth | MODERATE | Bismuth subsalicylate is predicted to increase the risk of bleeding events when given with Rivaro... |
| Ceritinib | MODERATE | Ceritinib might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impai... |
| Ciclosporin | MODERATE | Ciclosporin slightly increases the exposure to Rivaroxaban. Manufacturer advises caution in renal... |
| Clarithromycin | MODERATE | Clarithromycin slightly increases the exposure to Rivaroxaban. Manufacturer advises caution in re... |
| Dronedarone | MODERATE | Dronedarone might increase the exposure to Rivaroxaban. Manufacturer advises avoid. |
| Encorafenib | MODERATE | Encorafenib is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unle... |
| Enzalutamide | MODERATE | Enzalutamide is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unl... |
| Erythromycin | MODERATE | Erythromycin slightly increases the exposure to Rivaroxaban. Manufacturer advises caution in rena... |
| Glecaprevir | MODERATE | Glecaprevir might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal imp... |
| Idelalisib | MODERATE | Idelalisib might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impa... |
| Ivosidenib | MODERATE | Ivosidenib is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unles... |
| Lapatinib | MODERATE | Lapatinib might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impai... |
| Lumacaftor | MODERATE | Lumacaftor is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unles... |
| Mitotane | MODERATE | Mitotane is predicted to decrease the exposure to Rivaroxaban. Manufacturer advises avoid unless ... |
| Pibrentasvir | MODERATE | Pibrentasvir might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal im... |
| Ranolazine | MODERATE | Ranolazine might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impa... |
| Tucatinib | MODERATE | Tucatinib might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal impai... |
| Velpatasvir | MODERATE | Velpatasvir might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal imp... |
| Vemurafenib | MODERATE | Vemurafenib might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal imp... |
| Verapamil | MODERATE | Verapamil slightly increases the exposure to Rivaroxaban. Manufacturer advises caution in renal i... |
| Voxilaprevir | MODERATE | Voxilaprevir might increase the exposure to Rivaroxaban. Manufacturer advises caution in renal im... |
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