Spironolactone Drug Interactions
200Total Interactions
2Severe
2Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Abiraterone | SEVERE | Spironolactone might oppose the effects of Abiraterone. Manufacturer advises avoid. |
| Mitotane | SEVERE | Spironolactone is predicted to decrease the effects of Mitotane. Manufacturer advises avoid. |
| Digoxin | MODERATE | Spironolactone increases the concentration of Digoxin. Manufacturer advises monitor and adjust dose. |
| Lithium | MODERATE | Spironolactone potentially increases the concentration of Lithium. Manufacturer makes no recommen... |
| Acebutolol | LOW | Both Spironolactone and Acebutolol can increase the risk of hypotension. |
| Aceclofenac | LOW | Both Spironolactone and Aceclofenac can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Alcohol | LOW | Both Spironolactone and Alcohol can increase the risk of hypotension. |
| Alfuzosin | LOW | Both Spironolactone and Alfuzosin can increase the risk of hypotension. |
| Aliskiren | LOW | Both Spironolactone and Aliskiren can increase the risk of hypotension. |
| Alprostadil | LOW | Both Spironolactone and Alprostadil can increase the risk of hypotension. |
| Amantadine | LOW | Both Spironolactone and Amantadine can increase the risk of hypotension. |
| Amiloride | LOW | Both Spironolactone and Amiloride can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Amitriptyline | LOW | Both Spironolactone and Amitriptyline can increase the risk of hypotension. |
| Amlodipine | LOW | Both Spironolactone and Amlodipine can increase the risk of hypotension. |
| Apomorphine | LOW | Both Spironolactone and Apomorphine can increase the risk of hypotension. |
| Apraclonidine | LOW | Both Spironolactone and Apraclonidine can increase the risk of hypotension. |
| Aripiprazole | LOW | Both Spironolactone and Aripiprazole can increase the risk of hypotension. |
| Asenapine | LOW | Both Spironolactone and Asenapine can increase the risk of hypotension. |
| Atenolol | LOW | Both Spironolactone and Atenolol can increase the risk of hypotension. |
| Avanafil | LOW | Both Spironolactone and Avanafil can increase the risk of hypotension. |
| Azilsartan | LOW | Both Spironolactone and Azilsartan can increase the risk of hypotension. |
| Baclofen | LOW | Both Spironolactone and Baclofen can increase the risk of hypotension. |
| Bemiparin | LOW | Both Spironolactone and Bemiparin can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Bendroflumethiazide | LOW | Both Spironolactone and Bendroflumethiazide can increase the risk of hypotension. |
| Benperidol | LOW | Both Spironolactone and Benperidol can increase the risk of hypotension. |
| Betaxolol | LOW | Both Spironolactone and Betaxolol can increase the risk of hypotension. |
| Bisoprolol | LOW | Both Spironolactone and Bisoprolol can increase the risk of hypotension. |
| Bortezomib | LOW | Both Spironolactone and Bortezomib can increase the risk of hypotension. |
| Brimonidine | LOW | Both Spironolactone and Brimonidine can increase the risk of hypotension. |
| Bromfenac | LOW | Both Spironolactone and Bromfenac can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Bromocriptine | LOW | Both Spironolactone and Bromocriptine can increase the risk of hypotension. |
| Bumetanide | LOW | Both Spironolactone and Bumetanide can increase the risk of hypotension. |
| Cabergoline | LOW | Both Spironolactone and Cabergoline can increase the risk of hypotension. |
| Canagliflozin | LOW | Both Spironolactone and Canagliflozin can increase the risk of hypotension. |
| Candesartan | LOW | Both Spironolactone and Candesartan can increase the risk of hypotension. |
| Captopril | LOW | Both Spironolactone and Captopril can increase the risk of hypotension. |
| Cariprazine | LOW | Both Spironolactone and Cariprazine can increase the risk of hypotension. |
| Carvedilol | LOW | Both Spironolactone and Carvedilol can increase the risk of hypotension. |
| Celecoxib | LOW | Both Spironolactone and Celecoxib can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Celiprolol | LOW | Both Spironolactone and Celiprolol can increase the risk of hypotension. |
| Chlorothiazide | LOW | Both Spironolactone and Chlorothiazide can increase the risk of hypotension. |
| Chlorpromazine | LOW | Both Spironolactone and Chlorpromazine can increase the risk of hypotension. |
| Chlortalidone | LOW | Both Spironolactone and Chlortalidone can increase the risk of hypotension. |
| Ciclosporin | LOW | Both Spironolactone and Ciclosporin can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Clomipramine | LOW | Both Spironolactone and Clomipramine can increase the risk of hypotension. |
| Clonidine | LOW | Both Spironolactone and Clonidine can increase the risk of hypotension. |
| Clozapine | LOW | Both Spironolactone and Clozapine can increase the risk of hypotension. |
| Dalteparin | LOW | Both Spironolactone and Dalteparin can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Dapagliflozin | LOW | Both Spironolactone and Dapagliflozin can increase the risk of hypotension. |
| Desflurane | LOW | Both Spironolactone and Desflurane can increase the risk of hypotension. |
| Dexketoprofen | LOW | Both Spironolactone and Dexketoprofen can increase the risk of hyperkalaemia (hyperkalaemia is pa... |
| Diazoxide | LOW | Both Spironolactone and Diazoxide can increase the risk of hypotension. |
| Diclofenac | LOW | Both Spironolactone and Diclofenac can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Diltiazem | LOW | Both Spironolactone and Diltiazem can increase the risk of hypotension. |
| Dipyridamole | LOW | Both Spironolactone and Dipyridamole can increase the risk of hypotension. |
| Dosulepin | LOW | Both Spironolactone and Dosulepin can increase the risk of hypotension. |
| Doxazosin | LOW | Both Spironolactone and Doxazosin can increase the risk of hypotension. |
| Doxepin | LOW | Both Spironolactone and Doxepin can increase the risk of hypotension. |
| Droperidol | LOW | Both Spironolactone and Droperidol can increase the risk of hypotension. |
| Drospirenone | LOW | Both Spironolactone and Drospirenone can increase the risk of hyperkalaemia (hyperkalaemia is par... |
| Empagliflozin | LOW | Both Spironolactone and Empagliflozin can increase the risk of hypotension. |
| Enalapril | LOW | Both Spironolactone and Enalapril can increase the risk of hypotension. |
| Enoxaparin | LOW | Both Spironolactone and Enoxaparin can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Epoprostenol | LOW | Both Spironolactone and Epoprostenol can increase the risk of hypotension. |
| Eprosartan | LOW | Both Spironolactone and Eprosartan can increase the risk of hypotension. |
| Ertugliflozin | LOW | Both Spironolactone and Ertugliflozin can increase the risk of hypotension. |
| Esketamine | LOW | Both Spironolactone and Esketamine can increase the risk of hypotension. |
| Esmolol | LOW | Both Spironolactone and Esmolol can increase the risk of hypotension. |
| Etodolac | LOW | Both Spironolactone and Etodolac can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Etomidate | LOW | Both Spironolactone and Etomidate can increase the risk of hypotension. |
| Etoricoxib | LOW | Both Spironolactone and Etoricoxib can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Felodipine | LOW | Both Spironolactone and Felodipine can increase the risk of hypotension. |
| Flupentixol | LOW | Both Spironolactone and Flupentixol can increase the risk of hypotension. |
| Flurbiprofen | LOW | Both Spironolactone and Flurbiprofen can increase the risk of hyperkalaemia (hyperkalaemia is par... |
| Fosinopril | LOW | Both Spironolactone and Fosinopril can increase the risk of hypotension. |
| Foslevodopa | LOW | Both Spironolactone and Foslevodopa can increase the risk of hypotension. |
| Furosemide | LOW | Both Spironolactone and Furosemide can increase the risk of hypotension. |
| Glyceryl trinitrate | LOW | Both Spironolactone and Glyceryl trinitrate can increase the risk of hypotension. |
| Guanfacine | LOW | Both Spironolactone and Guanfacine can increase the risk of hypotension. |
| Haloperidol | LOW | Both Spironolactone and Haloperidol can increase the risk of hypotension. |
| Heparin | LOW | Both Spironolactone and Heparin can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Hydralazine | LOW | Both Spironolactone and Hydralazine can increase the risk of hypotension. |
| Hydrochlorothiazide | LOW | Both Spironolactone and Hydrochlorothiazide can increase the risk of hypotension. |
| Hydroflumethiazide | LOW | Both Spironolactone and Hydroflumethiazide can increase the risk of hypotension. |
| Ibuprofen | LOW | Both Spironolactone and Ibuprofen can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Iloprost | LOW | Both Spironolactone and Iloprost can increase the risk of hypotension. |
| Imidapril | LOW | Both Spironolactone and Imidapril can increase the risk of hypotension. |
| Imipramine | LOW | Both Spironolactone and Imipramine can increase the risk of hypotension. |
| Indapamide | LOW | Both Spironolactone and Indapamide can increase the risk of hypotension. |
| Indometacin | LOW | Both Spironolactone and Indometacin can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Indoramin | LOW | Both Spironolactone and Indoramin can increase the risk of hypotension. |
| Irbesartan | LOW | Both Spironolactone and Irbesartan can increase the risk of hypotension. |
| Isocarboxazid | LOW | Both Spironolactone and Isocarboxazid can increase the risk of hypotension. |
| Isoflurane | LOW | Both Spironolactone and Isoflurane can increase the risk of hypotension. |
| Isosorbide dinitrate | LOW | Both Spironolactone and Isosorbide dinitrate can increase the risk of hypotension. |
| Isosorbide mononitrate | LOW | Both Spironolactone and Isosorbide mononitrate can increase the risk of hypotension. |
| Ketamine | LOW | Both Spironolactone and Ketamine can increase the risk of hypotension. |
| Ketoprofen | LOW | Both Spironolactone and Ketoprofen can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Ketorolac | LOW | Both Spironolactone and Ketorolac can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Labetalol | LOW | Both Spironolactone and Labetalol can increase the risk of hypotension. |
| Lacidipine | LOW | Both Spironolactone and Lacidipine can increase the risk of hypotension. |
| Landiolol | LOW | Both Spironolactone and Landiolol can increase the risk of hypotension. |
| Lercanidipine | LOW | Both Spironolactone and Lercanidipine can increase the risk of hypotension. |
| Levobunolol | LOW | Both Spironolactone and Levobunolol can increase the risk of hypotension. |
| Levodopa | LOW | Both Spironolactone and Levodopa can increase the risk of hypotension. |
| Levomepromazine | LOW | Both Spironolactone and Levomepromazine can increase the risk of hypotension. |
| Lisinopril | LOW | Both Spironolactone and Lisinopril can increase the risk of hypotension. |
| Lofepramine | LOW | Both Spironolactone and Lofepramine can increase the risk of hypotension. |
| Lofexidine | LOW | Both Spironolactone and Lofexidine can increase the risk of hypotension. |
| Losartan | LOW | Both Spironolactone and Losartan can increase the risk of hypotension. |
| Loxapine | LOW | Both Spironolactone and Loxapine can increase the risk of hypotension. |
| Lurasidone | LOW | Both Spironolactone and Lurasidone can increase the risk of hypotension. |
| Mefenamic acid | LOW | Both Spironolactone and Mefenamic acid can increase the risk of hyperkalaemia (hyperkalaemia is p... |
| Meloxicam | LOW | Both Spironolactone and Meloxicam can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Methoxyflurane | LOW | Both Spironolactone and Methoxyflurane can increase the risk of hypotension. |
| Methyldopa | LOW | Both Spironolactone and Methyldopa can increase the risk of hypotension. |
| Metolazone | LOW | Both Spironolactone and Metolazone can increase the risk of hypotension. |
| Metoprolol | LOW | Both Spironolactone and Metoprolol can increase the risk of hypotension. |
| Minoxidil | LOW | Both Spironolactone and Minoxidil can increase the risk of hypotension. |
| Moxonidine | LOW | Both Spironolactone and Moxonidine can increase the risk of hypotension. |
| Nabumetone | LOW | Both Spironolactone and Nabumetone can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Nadolol | LOW | Both Spironolactone and Nadolol can increase the risk of hypotension. |
| Naproxen | LOW | Both Spironolactone and Naproxen can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Nebivolol | LOW | Both Spironolactone and Nebivolol can increase the risk of hypotension. |
| Nicardipine | LOW | Both Spironolactone and Nicardipine can increase the risk of hypotension. |
| Nicorandil | LOW | Both Spironolactone and Nicorandil can increase the risk of hypotension. |
| Nifedipine | LOW | Both Spironolactone and Nifedipine can increase the risk of hypotension. |
| Nimodipine | LOW | Both Spironolactone and Nimodipine can increase the risk of hypotension. |
| Nitroprusside | LOW | Both Spironolactone and Nitroprusside can increase the risk of hypotension. |
| Nitrous oxide | LOW | Both Spironolactone and Nitrous oxide can increase the risk of hypotension. |
| Nortriptyline | LOW | Both Spironolactone and Nortriptyline can increase the risk of hypotension. |
| Olanzapine | LOW | Both Spironolactone and Olanzapine can increase the risk of hypotension. |
| Olmesartan | LOW | Both Spironolactone and Olmesartan can increase the risk of hypotension. |
| Paliperidone | LOW | Both Spironolactone and Paliperidone can increase the risk of hypotension. |
| Parecoxib | LOW | Both Spironolactone and Parecoxib can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Pentamidine | LOW | Both Spironolactone and Pentamidine can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Pericyazine | LOW | Both Spironolactone and Pericyazine can increase the risk of hypotension. |
| Perindopril | LOW | Both Spironolactone and Perindopril can increase the risk of hypotension. |
| Phenazone | LOW | Both Spironolactone and Phenazone can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Phenelzine | LOW | Both Spironolactone and Phenelzine can increase the risk of hypotension. |
| Pimozide | LOW | Both Spironolactone and Pimozide can increase the risk of hypotension. |
| Pindolol | LOW | Both Spironolactone and Pindolol can increase the risk of hypotension. |
| Piroxicam | LOW | Both Spironolactone and Piroxicam can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Potassium aminobenzoate | LOW | Both Spironolactone and Potassium aminobenzoate can increase the risk of hyperkalaemia (hyperkala... |
| Potassium canrenoate | LOW | Both Spironolactone and Potassium canrenoate can increase the risk of hyperkalaemia (hyperkalaemi... |
| Potassium chloride | LOW | Both Spironolactone and Potassium chloride can increase the risk of hyperkalaemia (hyperkalaemia ... |
| Pramipexole | LOW | Both Spironolactone and Pramipexole can increase the risk of hypotension. |
| Prazosin | LOW | Both Spironolactone and Prazosin can increase the risk of hypotension. |
| Prochlorperazine | LOW | Both Spironolactone and Prochlorperazine can increase the risk of hypotension. |
| Promazine | LOW | Both Spironolactone and Promazine can increase the risk of hypotension. |
| Propofol | LOW | Both Spironolactone and Propofol can increase the risk of hypotension. |
| Propranolol | LOW | Both Spironolactone and Propranolol can increase the risk of hypotension. |
| Quetiapine | LOW | Both Spironolactone and Quetiapine can increase the risk of hypotension. |
| Quinagolide | LOW | Both Spironolactone and Quinagolide can increase the risk of hypotension. |
| Quinapril | LOW | Both Spironolactone and Quinapril can increase the risk of hypotension. |
| Ramipril | LOW | Both Spironolactone and Ramipril can increase the risk of hypotension. |
| Riociguat | LOW | Both Spironolactone and Riociguat can increase the risk of hypotension. |
| Risperidone | LOW | Both Spironolactone and Risperidone can increase the risk of hypotension. |
| Ropinirole | LOW | Both Spironolactone and Ropinirole can increase the risk of hypotension. |
| Rotigotine | LOW | Both Spironolactone and Rotigotine can increase the risk of hypotension. |
| Sacubitril | LOW | Both Spironolactone and Sacubitril can increase the risk of hypotension. |
| Sapropterin | LOW | Both Spironolactone and Sapropterin can increase the risk of hypotension. |
| Selegiline | LOW | Both Spironolactone and Selegiline can increase the risk of hypotension. |
| Sevoflurane | LOW | Both Spironolactone and Sevoflurane can increase the risk of hypotension. |
| Sildenafil | LOW | Both Spironolactone and Sildenafil can increase the risk of hypotension. |
| Sodium oxybate | LOW | Both Spironolactone and Sodium oxybate can increase the risk of hypotension. |
| Sotalol | LOW | Both Spironolactone and Sotalol can increase the risk of hypotension. |
| Sparsentan | LOW | Both Spironolactone and Sparsentan can increase the risk of hypotension. |
| Sulindac | LOW | Both Spironolactone and Sulindac can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Sulpiride | LOW | Both Spironolactone and Sulpiride can increase the risk of hypotension. |
| Suxamethonium | LOW | Both Spironolactone and Suxamethonium can increase the risk of hyperkalaemia (hyperkalaemia is pa... |
| Tacrolimus | LOW | Both Spironolactone and Tacrolimus can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Tadalafil | LOW | Both Spironolactone and Tadalafil can increase the risk of hypotension. |
| Tamsulosin | LOW | Both Spironolactone and Tamsulosin can increase the risk of hypotension. |
| Telmisartan | LOW | Both Spironolactone and Telmisartan can increase the risk of hypotension. |
| Tenoxicam | LOW | Both Spironolactone and Tenoxicam can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Terazosin | LOW | Both Spironolactone and Terazosin can increase the risk of hypotension. |
| Thiopental | LOW | Both Spironolactone and Thiopental can increase the risk of hypotension. |
| Tiaprofenic acid | LOW | Both Spironolactone and Tiaprofenic acid can increase the risk of hyperkalaemia (hyperkalaemia is... |
| Timolol | LOW | Both Spironolactone and Timolol can increase the risk of hypotension. |
| Tinzaparin | LOW | Both Spironolactone and Tinzaparin can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Tizanidine | LOW | Both Spironolactone and Tizanidine can increase the risk of hypotension. |
| Tolfenamic acid | LOW | Both Spironolactone and Tolfenamic acid can increase the risk of hyperkalaemia (hyperkalaemia is ... |
| Tolvaptan | LOW | Both Spironolactone and Tolvaptan can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Torasemide | LOW | Both Spironolactone and Torasemide can increase the risk of hypotension. |
| Trandolapril | LOW | Both Spironolactone and Trandolapril can increase the risk of hypotension. |
| Tranylcypromine | LOW | Both Spironolactone and Tranylcypromine can increase the risk of hypotension. |
| Treprostinil | LOW | Both Spironolactone and Treprostinil can increase the risk of hypotension. |
| Triamterene | LOW | Both Spironolactone and Triamterene can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Trifluoperazine | LOW | Both Spironolactone and Trifluoperazine can increase the risk of hypotension. |
| Trimethoprim | LOW | Both Spironolactone and Trimethoprim can increase the risk of hyperkalaemia (hyperkalaemia is par... |
| Trimipramine | LOW | Both Spironolactone and Trimipramine can increase the risk of hypotension. |
| Valsartan | LOW | Both Spironolactone and Valsartan can increase the risk of hypotension. |
| Vardenafil | LOW | Both Spironolactone and Vardenafil can increase the risk of hypotension. |
| Verapamil | LOW | Both Spironolactone and Verapamil can increase the risk of hypotension. |
| Vericiguat | LOW | Both Spironolactone and Vericiguat can increase the risk of hypotension. |
| Vernakalant | LOW | Both Spironolactone and Vernakalant can increase the risk of hypotension. |
| Voclosporin | LOW | Both Spironolactone and Voclosporin can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Xipamide | LOW | Both Spironolactone and Xipamide can increase the risk of hypotension. |
| Zuclopenthixol | LOW | Both Spironolactone and Zuclopenthixol can increase the risk of hypotension. |
Check Spironolactone against your patient's full medication list
InteractRx checks all drug combinations at once — built for GP surgery pharmacists.
Use the Free Checker