Theophylline Drug Interactions
168Total Interactions
98Severe
36Moderate
2Mild
| Drug | Severity | Summary |
|---|---|---|
| Acebutolol | SEVERE | Acebutolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufa... |
| Aciclovir | SEVERE | Aciclovir is predicted to increase the exposure to Theophylline. Manufacturer advises monitor and... |
| Amifampridine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Amiodarone | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Amisulpride | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Anagrelide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Apalutamide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Apomorphine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Aripiprazole | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Arsenic trioxide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Artemether | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Artenimol | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Atenolol | SEVERE | Atenolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufact... |
| Bedaquiline | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Betaxolol | SEVERE | Betaxolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufac... |
| Bisoprolol | SEVERE | Bisoprolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufa... |
| Bosutinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Cabozantinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Carvedilol | SEVERE | Carvedilol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufa... |
| Celiprolol | SEVERE | Celiprolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufa... |
| Ceritinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Chlorpromazine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Cimetidine | SEVERE | Cimetidine increases the concentration of Theophylline. Manufacturer advises adjust dose. |
| Citalopram | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Clomipramine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Crizotinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Dasatinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Delamanid | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Desflurane | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Digoxin | SEVERE | Theophylline is predicted to increase the risk of Digoxin toxicity when given with Digoxin. Manuf... |
| Disopyramide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Dronedarone | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Droperidol | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Efavirenz | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Encorafenib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Entrectinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Eribulin | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Erythromycin | SEVERE | Erythromycin decreases the clearance of Theophylline and Theophylline potentially decreases the c... |
| Escitalopram | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Esketamine | SEVERE | Esketamine is predicted to increase the risk of seizures when given with Theophylline. Manufactur... |
| Esmolol | SEVERE | Esmolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufactu... |
| Fluconazole | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Fluvoxamine | SEVERE | Fluvoxamine moderately to markedly increases the exposure to Theophylline. Manufacturer advises a... |
| Glasdegib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Haloperidol | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Hydroxychloroquine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Hydroxyzine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Inotuzumab ozogamicin | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Isoflurane | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Isoniazid | SEVERE | Isoniazid is predicted to affect the clearance of Theophylline. Manufacturer advises monitor. |
| Ivosidenib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Labetalol | SEVERE | Labetalol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufac... |
| Landiolol | SEVERE | Landiolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufac... |
| Lapatinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Lenvatinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Levobunolol | SEVERE | Levobunolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manuf... |
| Levomepromazine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Methadone | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Metoprolol | SEVERE | Metoprolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufa... |
| Metreleptin | SEVERE | Metreleptin might alter the exposure to Theophylline. Manufacturer advises monitor concentration ... |
| Moxifloxacin | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Nadolol | SEVERE | Nadolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufactu... |
| Nebivolol | SEVERE | Nebivolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufac... |
| Nilotinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Obeticholic acid | SEVERE | Obeticholic acid is predicted to increase the exposure to Theophylline. Manufacturer advises moni... |
| Ondansetron | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Osilodrostat | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Osimertinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Paliperidone | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Panobinostat | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Pasireotide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Pazopanib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Pentoxifylline | SEVERE | Pentoxifylline increases the concentration of Theophylline. Manufacturer advises monitor and adju... |
| Pimozide | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Pindolol | SEVERE | Pindolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufact... |
| Promethazine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Propranolol | SEVERE | Propranolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manuf... |
| Quinine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Quizartinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Ranolazine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Ribociclib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Selpercatinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Sevoflurane | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Sorafenib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Sotalol | SEVERE | Sotalol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufactu... |
| St John's wort | SEVERE | St John's wort potentially decreases the exposure to Theophylline. Manufacturer makes no recommen... |
| Sunitinib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Tetrabenazine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Timolol | SEVERE | Timolol is predicted to increase the risk of bronchospasm when given with Theophylline. Manufactu... |
| Tolterodine | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Toremifene | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Valaciclovir | SEVERE | Valaciclovir is predicted to increase the exposure to Theophylline. Manufacturer makes no recomme... |
| Vandetanib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Vardenafil | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Vemurafenib | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Vernakalant | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Voclosporin | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Voriconazole | SEVERE | Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de po... |
| Axitinib | MODERATE | Axitinib is predicted to increase the exposure to Theophylline. Manufacturer makes no recommendat... |
| Azithromycin | MODERATE | Azithromycin is predicted to increase the exposure to Theophylline. Manufacturer advises adjust d... |
| Blinatumomab | MODERATE | Blinatumomab is predicted to transiently increase the exposure to Theophylline. Manufacturer advi... |
| Caffeine citrate | MODERATE | Caffeine citrate decreases the clearance of Theophylline. Manufacturer makes no recommendation. |
| Carbamazepine | MODERATE | Carbamazepine potentially increases the clearance of Theophylline and Theophylline decreases the ... |
| Ciprofloxacin | MODERATE | Ciprofloxacin is predicted to increase the exposure to Theophylline. Manufacturer advises monitor... |
| Clarithromycin | MODERATE | Clarithromycin is predicted to increase the exposure to Theophylline. Manufacturer advises adjust... |
| Combined hormonal contraceptives | MODERATE | Combined hormonal contraceptives is predicted to increase the exposure to Theophylline. Manufactu... |
| Deferasirox | MODERATE | Deferasirox increases the exposure to Theophylline. Manufacturer advises avoid. |
| Doxapram | MODERATE | Theophylline increases the risk of agitation when given with Doxapram. Manufacturer advises caution. |
| Enteral feeds | MODERATE | Enteral feeds decrease the exposure to Theophylline. Manufacturer makes no recommendation. |
| Ephedrine | MODERATE | Ephedrine increases the risk of adverse effects when given with Theophylline. Manufacturer advise... |
| Fosphenytoin | MODERATE | Fosphenytoin is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust d... |
| Givosiran | MODERATE | Givosiran is predicted to increase the exposure to Theophylline. Manufacturer advises monitor and... |
| Interferon beta | MODERATE | Interferon beta slightly increases the exposure to Theophylline. Manufacturer advises adjust dose. |
| Leflunomide | MODERATE | Leflunomide is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust dose. |
| Leniolisib | MODERATE | Leniolisib is predicted to increase the exposure to Theophylline. Manufacturer advises avoid. |
| Lithium | MODERATE | Theophylline is predicted to decrease the concentration of Lithium. Manufacturer advises monitor ... |
| Methotrexate | MODERATE | Methotrexate decreases the clearance of Theophylline. Manufacturer makes no recommendation. |
| Mexiletine | MODERATE | Mexiletine is predicted to increase the exposure to Theophylline. Manufacturer advises monitor an... |
| Nirmatrelvir | MODERATE | Nirmatrelvir boosted with ritonavir is predicted to decrease the concentration of Theophylline. M... |
| Peginterferon alfa | MODERATE | Peginterferon alfa slightly increases the exposure to Theophylline. Manufacturer advises adjust d... |
| Phenobarbital | MODERATE | Phenobarbital is predicted to increase the clearance of Theophylline. Manufacturer advises adjust... |
| Phenytoin | MODERATE | Phenytoin is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust dose. |
| Primidone | MODERATE | Primidone is predicted to increase the clearance of Theophylline. Manufacturer advises adjust dose. |
| Rifampicin | MODERATE | Rifampicin is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust dose. |
| Ritlecitinib | MODERATE | Ritlecitinib is predicted to increase the exposure to Theophylline. Manufacturer advises adjust d... |
| Ritonavir | MODERATE | Ritonavir is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust dose. |
| Roflumilast | MODERATE | Theophylline is predicted to slightly increase the exposure to Roflumilast. Manufacturer advises ... |
| Ropeginterferon alfa | MODERATE | Ropeginterferon alfa slightly increases the exposure to Theophylline. Manufacturer advises adjust... |
| Rucaparib | MODERATE | Rucaparib is predicted to increase the exposure to Theophylline. Manufacturer advises monitor and... |
| Sarilumab | MODERATE | Sarilumab potentially affects the exposure to Theophylline. Manufacturer advises monitor and adju... |
| Stiripentol | MODERATE | Stiripentol is predicted to increase the exposure to Theophylline. Manufacturer advises avoid. |
| Sucralfate | MODERATE | Sucralfate potentially decreases the absorption of Theophylline. Manufacturer advises separate ad... |
| Teriflunomide | MODERATE | Teriflunomide is predicted to decrease the exposure to Theophylline. Manufacturer advises adjust ... |
| Tocilizumab | MODERATE | Tocilizumab is predicted to decrease the exposure to Theophylline. Manufacturer advises monitor a... |
| Adenosine | MILD | Theophylline decreases the efficacy of Adenosine. Manufacturer advises separate administration by... |
| Maribavir | MILD | Maribavir is predicted to decrease the exposure to Theophylline. Manufacturer advises avoid. |
| Aminophylline | LOW | Both Theophylline and Aminophylline can increase the risk of hypokalaemia. |
| Amphotericin B | LOW | Both Theophylline and Amphotericin B can increase the risk of hypokalaemia. |
| Beclometasone | LOW | Both Theophylline and Beclometasone can increase the risk of hypokalaemia. |
| Bendroflumethiazide | LOW | Both Theophylline and Bendroflumethiazide can increase the risk of hypokalaemia. |
| Betamethasone | LOW | Both Theophylline and Betamethasone can increase the risk of hypokalaemia. |
| Budesonide | LOW | Both Theophylline and Budesonide can increase the risk of hypokalaemia. |
| Bumetanide | LOW | Both Theophylline and Bumetanide can increase the risk of hypokalaemia. |
| Chlorothiazide | LOW | Both Theophylline and Chlorothiazide can increase the risk of hypokalaemia. |
| Chlortalidone | LOW | Both Theophylline and Chlortalidone can increase the risk of hypokalaemia. |
| Deflazacort | LOW | Both Theophylline and Deflazacort can increase the risk of hypokalaemia. |
| Dexamethasone | LOW | Both Theophylline and Dexamethasone can increase the risk of hypokalaemia. |
| Fludrocortisone | LOW | Both Theophylline and Fludrocortisone can increase the risk of hypokalaemia. |
| Formoterol | LOW | Both Theophylline and Formoterol can increase the risk of hypokalaemia. |
| Furosemide | LOW | Both Theophylline and Furosemide can increase the risk of hypokalaemia. |
| Hydrochlorothiazide | LOW | Both Theophylline and Hydrochlorothiazide can increase the risk of hypokalaemia. |
| Hydrocortisone | LOW | Both Theophylline and Hydrocortisone can increase the risk of hypokalaemia. |
| Hydroflumethiazide | LOW | Both Theophylline and Hydroflumethiazide can increase the risk of hypokalaemia. |
| Indacaterol | LOW | Both Theophylline and Indacaterol can increase the risk of hypokalaemia. |
| Indapamide | LOW | Both Theophylline and Indapamide can increase the risk of hypokalaemia. |
| Isoprenaline | LOW | Both Theophylline and Isoprenaline can increase the risk of hypokalaemia. |
| Methylprednisolone | LOW | Both Theophylline and Methylprednisolone can increase the risk of hypokalaemia. |
| Metolazone | LOW | Both Theophylline and Metolazone can increase the risk of hypokalaemia. |
| Olodaterol | LOW | Both Theophylline and Olodaterol can increase the risk of hypokalaemia. |
| Prednisolone | LOW | Both Theophylline and Prednisolone can increase the risk of hypokalaemia. |
| Salbutamol | LOW | Both Theophylline and Salbutamol can increase the risk of hypokalaemia. |
| Salmeterol | LOW | Both Theophylline and Salmeterol can increase the risk of hypokalaemia. |
| Terbutaline | LOW | Both Theophylline and Terbutaline can increase the risk of hypokalaemia. |
| Torasemide | LOW | Both Theophylline and Torasemide can increase the risk of hypokalaemia. |
| Triamcinolone | LOW | Both Theophylline and Triamcinolone can increase the risk of hypokalaemia. |
| Vamorolone | LOW | Both Theophylline and Vamorolone can increase the risk of hypokalaemia. |
| Vilanterol | LOW | Both Theophylline and Vilanterol can increase the risk of hypokalaemia. |
| Xipamide | LOW | Both Theophylline and Xipamide can increase the risk of hypokalaemia. |
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