Trimethoprim Drug Interactions
126Total Interactions
8Severe
10Moderate
0Mild
| Drug | Severity | Summary |
|---|---|---|
| Acenocoumarol | SEVERE | Trimethoprim is predicted to increase the anticoagulant effect of Acenocoumarol. Manufacturer mak... |
| Azathioprine | SEVERE | Trimethoprim might increase the risk of haematological toxicity when given with Azathioprine in r... |
| Clozapine | SEVERE | Trimethoprim might increase the risk of neutropenia when given with Clozapine. Manufacturer advis... |
| Dapsone | SEVERE | Dapsone increases the exposure to Trimethoprim and Trimethoprim increases the exposure to Dapsone... |
| Mercaptopurine | SEVERE | Trimethoprim might increase the risk of haematological toxicity when given with Mercaptopurine in... |
| Methotrexate | SEVERE | Trimethoprim increases the risk of haematological side-effects (sometimes fatal) when given with ... |
| Pyrimethamine | SEVERE | Pyrimethamine increases the risk of adverse effects when given with Trimethoprim. Manufacturer ma... |
| Warfarin | SEVERE | Trimethoprim is predicted to increase the anticoagulant effect of Warfarin. Manufacturer makes no... |
| Digoxin | MODERATE | Trimethoprim increases the concentration of Digoxin. Manufacturer advises monitor Digoxin concent... |
| Fosphenytoin | MODERATE | Trimethoprim increases the concentration of Fosphenytoin. Manufacturer advises monitor concentrat... |
| Lamivudine | MODERATE | Trimethoprim slightly increases the exposure to Lamivudine. Manufacturer advises monitor. |
| Metformin | MODERATE | Trimethoprim is predicted to increase the exposure to Metformin. Manufacturer advises use with ca... |
| Phenytoin | MODERATE | Trimethoprim increases the concentration of Phenytoin. Manufacturer advises monitor concentration. |
| Pramipexole | MODERATE | Trimethoprim is predicted to increase the exposure to Pramipexole. Manufacturer advises adjust dose. |
| Repaglinide | MODERATE | Trimethoprim slightly increases the exposure to Repaglinide. Manufacturer advises avoid or monito... |
| Rifampicin | MODERATE | Rifampicin decreases the exposure to Trimethoprim. Manufacturer makes no recommendation. |
| Sapropterin | MODERATE | Trimethoprim is predicted to decrease the efficacy of Sapropterin. Manufacturer advises caution. |
| Treprostinil | MODERATE | Trimethoprim is predicted to increase the exposure to Treprostinil. Manufacturer advises adjust d... |
| Aceclofenac | LOW | Both Trimethoprim and Aceclofenac can increase the risk of nephrotoxicity. |
| Aciclovir | LOW | Both Trimethoprim and Aciclovir can increase the risk of nephrotoxicity. |
| Aliskiren | LOW | Both Trimethoprim and Aliskiren can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Amikacin | LOW | Both Trimethoprim and Amikacin can increase the risk of nephrotoxicity. |
| Amiloride | LOW | Both Trimethoprim and Amiloride can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Amphotericin B | LOW | Both Trimethoprim and Amphotericin B can increase the risk of nephrotoxicity. |
| Aspirin | LOW | Both Trimethoprim and Aspirin can increase the risk of nephrotoxicity. |
| Azilsartan | LOW | Both Trimethoprim and Azilsartan can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Bemiparin | LOW | Both Trimethoprim and Bemiparin can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Bromfenac | LOW | Both Trimethoprim and Bromfenac can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Candesartan | LOW | Both Trimethoprim and Candesartan can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Captopril | LOW | Both Trimethoprim and Captopril can increase the risk of nephrotoxicity. |
| Carboplatin | LOW | Both Trimethoprim and Carboplatin can increase the risk of nephrotoxicity. |
| Cefaclor | LOW | Both Trimethoprim and Cefaclor can increase the risk of nephrotoxicity. |
| Cefadroxil | LOW | Both Trimethoprim and Cefadroxil can increase the risk of nephrotoxicity. |
| Cefalexin | LOW | Both Trimethoprim and Cefalexin can increase the risk of nephrotoxicity. |
| Cefazolin | LOW | Both Trimethoprim and Cefazolin can increase the risk of nephrotoxicity. |
| Cefepime | LOW | Both Trimethoprim and Cefepime can increase the risk of nephrotoxicity. |
| Cefixime | LOW | Both Trimethoprim and Cefixime can increase the risk of nephrotoxicity. |
| Cefotaxime | LOW | Both Trimethoprim and Cefotaxime can increase the risk of nephrotoxicity. |
| Cefoxitin | LOW | Both Trimethoprim and Cefoxitin can increase the risk of nephrotoxicity. |
| Cefradine | LOW | Both Trimethoprim and Cefradine can increase the risk of nephrotoxicity. |
| Ceftaroline | LOW | Both Trimethoprim and Ceftaroline can increase the risk of nephrotoxicity. |
| Ceftazidime | LOW | Both Trimethoprim and Ceftazidime can increase the risk of nephrotoxicity. |
| Ceftobiprole | LOW | Both Trimethoprim and Ceftobiprole can increase the risk of nephrotoxicity. |
| Ceftolozane | LOW | Both Trimethoprim and Ceftolozane can increase the risk of nephrotoxicity. |
| Ceftriaxone | LOW | Both Trimethoprim and Ceftriaxone can increase the risk of nephrotoxicity. |
| Cefuroxime | LOW | Both Trimethoprim and Cefuroxime can increase the risk of nephrotoxicity. |
| Celecoxib | LOW | Both Trimethoprim and Celecoxib can increase the risk of nephrotoxicity. |
| Ciclosporin | LOW | Both Trimethoprim and Ciclosporin can increase the risk of nephrotoxicity. |
| Cidofovir | LOW | Both Trimethoprim and Cidofovir can increase the risk of nephrotoxicity. |
| Cisplatin | LOW | Both Trimethoprim and Cisplatin can increase the risk of nephrotoxicity. |
| Colistimethate | LOW | Both Trimethoprim and Colistimethate can increase the risk of nephrotoxicity. |
| Dalteparin | LOW | Both Trimethoprim and Dalteparin can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Deferasirox | LOW | Both Trimethoprim and Deferasirox can increase the risk of nephrotoxicity. |
| Dexketoprofen | LOW | Both Trimethoprim and Dexketoprofen can increase the risk of nephrotoxicity. |
| Diclofenac | LOW | Both Trimethoprim and Diclofenac can increase the risk of nephrotoxicity. |
| Drospirenone | LOW | Both Trimethoprim and Drospirenone can increase the risk of hyperkalaemia (hyperkalaemia is parti... |
| Enalapril | LOW | Both Trimethoprim and Enalapril can increase the risk of nephrotoxicity. |
| Enoxaparin | LOW | Both Trimethoprim and Enoxaparin can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Eplerenone | LOW | Both Trimethoprim and Eplerenone can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Eprosartan | LOW | Both Trimethoprim and Eprosartan can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Etodolac | LOW | Both Trimethoprim and Etodolac can increase the risk of nephrotoxicity. |
| Etoricoxib | LOW | Both Trimethoprim and Etoricoxib can increase the risk of nephrotoxicity. |
| Finerenone | LOW | Both Trimethoprim and Finerenone can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Flurbiprofen | LOW | Both Trimethoprim and Flurbiprofen can increase the risk of nephrotoxicity. |
| Foscarnet | LOW | Both Trimethoprim and Foscarnet can increase the risk of nephrotoxicity. |
| Fosinopril | LOW | Both Trimethoprim and Fosinopril can increase the risk of nephrotoxicity. |
| Ganciclovir | LOW | Both Trimethoprim and Ganciclovir can increase the risk of nephrotoxicity. |
| Gentamicin | LOW | Both Trimethoprim and Gentamicin can increase the risk of nephrotoxicity. |
| Heparin | LOW | Both Trimethoprim and Heparin can increase the risk of hyperkalaemia (hyperkalaemia is particular... |
| Ibuprofen | LOW | Both Trimethoprim and Ibuprofen can increase the risk of nephrotoxicity. |
| Ifosfamide | LOW | Both Trimethoprim and Ifosfamide can increase the risk of nephrotoxicity. |
| Imidapril | LOW | Both Trimethoprim and Imidapril can increase the risk of nephrotoxicity. |
| Indometacin | LOW | Both Trimethoprim and Indometacin can increase the risk of nephrotoxicity. |
| Inotersen | LOW | Both Trimethoprim and Inotersen can increase the risk of nephrotoxicity. |
| Irbesartan | LOW | Both Trimethoprim and Irbesartan can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Ketoprofen | LOW | Both Trimethoprim and Ketoprofen can increase the risk of nephrotoxicity. |
| Ketorolac | LOW | Both Trimethoprim and Ketorolac can increase the risk of nephrotoxicity. |
| Labetalol | LOW | Both Trimethoprim and Labetalol can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Lisinopril | LOW | Both Trimethoprim and Lisinopril can increase the risk of nephrotoxicity. |
| Lithium | LOW | Both Trimethoprim and Lithium can increase the risk of nephrotoxicity. |
| Losartan | LOW | Both Trimethoprim and Losartan can increase the risk of hyperkalaemia (hyperkalaemia is particula... |
| Mefenamic acid | LOW | Both Trimethoprim and Mefenamic acid can increase the risk of nephrotoxicity. |
| Meloxicam | LOW | Both Trimethoprim and Meloxicam can increase the risk of nephrotoxicity. |
| Mesalazine | LOW | Both Trimethoprim and Mesalazine can increase the risk of nephrotoxicity. |
| Nabumetone | LOW | Both Trimethoprim and Nabumetone can increase the risk of nephrotoxicity. |
| Naproxen | LOW | Both Trimethoprim and Naproxen can increase the risk of nephrotoxicity. |
| Neomycin | LOW | Both Trimethoprim and Neomycin can increase the risk of nephrotoxicity. |
| Netilmicin | LOW | Both Trimethoprim and Netilmicin can increase the risk of nephrotoxicity. |
| Olmesartan | LOW | Both Trimethoprim and Olmesartan can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Oxaliplatin | LOW | Both Trimethoprim and Oxaliplatin can increase the risk of nephrotoxicity. |
| Pamidronate | LOW | Both Trimethoprim and Pamidronate can increase the risk of nephrotoxicity. |
| Parecoxib | LOW | Both Trimethoprim and Parecoxib can increase the risk of nephrotoxicity. |
| Pemetrexed | LOW | Both Trimethoprim and Pemetrexed can increase the risk of nephrotoxicity. |
| Pentamidine | LOW | Both Trimethoprim and Pentamidine can increase the risk of nephrotoxicity. |
| Perindopril | LOW | Both Trimethoprim and Perindopril can increase the risk of nephrotoxicity. |
| Phenazone | LOW | Both Trimethoprim and Phenazone can increase the risk of nephrotoxicity. |
| Piroxicam | LOW | Both Trimethoprim and Piroxicam can increase the risk of nephrotoxicity. |
| Potassium aminobenzoate | LOW | Both Trimethoprim and Potassium aminobenzoate can increase the risk of hyperkalaemia (hyperkalaem... |
| Potassium canrenoate | LOW | Both Trimethoprim and Potassium canrenoate can increase the risk of hyperkalaemia (hyperkalaemia ... |
| Potassium chloride | LOW | Both Trimethoprim and Potassium chloride can increase the risk of hyperkalaemia (hyperkalaemia is... |
| Quinapril | LOW | Both Trimethoprim and Quinapril can increase the risk of nephrotoxicity. |
| Ramipril | LOW | Both Trimethoprim and Ramipril can increase the risk of nephrotoxicity. |
| Sparsentan | LOW | Both Trimethoprim and Sparsentan can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Spironolactone | LOW | Both Trimethoprim and Spironolactone can increase the risk of hyperkalaemia (hyperkalaemia is par... |
| Streptomycin | LOW | Both Trimethoprim and Streptomycin can increase the risk of nephrotoxicity. |
| Streptozocin | LOW | Both Trimethoprim and Streptozocin can increase the risk of nephrotoxicity. |
| Sulfasalazine | LOW | Both Trimethoprim and Sulfasalazine can increase the risk of nephrotoxicity. |
| Sulindac | LOW | Both Trimethoprim and Sulindac can increase the risk of nephrotoxicity. |
| Suxamethonium | LOW | Both Trimethoprim and Suxamethonium can increase the risk of hyperkalaemia (hyperkalaemia is part... |
| Tacrolimus | LOW | Both Trimethoprim and Tacrolimus can increase the risk of nephrotoxicity. |
| Telmisartan | LOW | Both Trimethoprim and Telmisartan can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Tenofovir disoproxil | LOW | Both Trimethoprim and Tenofovir disoproxil can increase the risk of nephrotoxicity. |
| Tenoxicam | LOW | Both Trimethoprim and Tenoxicam can increase the risk of nephrotoxicity. |
| Tiaprofenic acid | LOW | Both Trimethoprim and Tiaprofenic acid can increase the risk of nephrotoxicity. |
| Tinzaparin | LOW | Both Trimethoprim and Tinzaparin can increase the risk of hyperkalaemia (hyperkalaemia is particu... |
| Tobramycin | LOW | Both Trimethoprim and Tobramycin can increase the risk of nephrotoxicity. |
| Tolfenamic acid | LOW | Both Trimethoprim and Tolfenamic acid can increase the risk of nephrotoxicity. |
| Tolvaptan | LOW | Both Trimethoprim and Tolvaptan can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Trandolapril | LOW | Both Trimethoprim and Trandolapril can increase the risk of nephrotoxicity. |
| Triamterene | LOW | Both Trimethoprim and Triamterene can increase the risk of hyperkalaemia (hyperkalaemia is partic... |
| Valaciclovir | LOW | Both Trimethoprim and Valaciclovir can increase the risk of nephrotoxicity. |
| Valganciclovir | LOW | Both Trimethoprim and Valganciclovir can increase the risk of nephrotoxicity. |
| Valsartan | LOW | Both Trimethoprim and Valsartan can increase the risk of hyperkalaemia (hyperkalaemia is particul... |
| Vancomycin | LOW | Both Trimethoprim and Vancomycin can increase the risk of nephrotoxicity. |
| Voclosporin | LOW | Both Trimethoprim and Voclosporin can increase the risk of nephrotoxicity. |
| Zoledronate | LOW | Both Trimethoprim and Zoledronate can increase the risk of nephrotoxicity. |
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