Venlafaxine Drug Interactions
308Total Interactions
104Severe
14Moderate
2Mild
| Drug | Severity | Summary |
|---|---|---|
| Acalabrutinib | SEVERE | Both Venlafaxine and Acalabrutinib can increase the risk of bleeding. |
| Aceclofenac | SEVERE | Both Venlafaxine and Aceclofenac can increase the risk of bleeding. |
| Acenocoumarol | SEVERE | Acenocoumarol causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of dev... |
| Alprostadil | SEVERE | Both Venlafaxine and Alprostadil can increase the risk of bleeding. |
| Alteplase | SEVERE | Alteplase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develop... |
| Anagrelide | SEVERE | Both Venlafaxine and Anagrelide can increase the risk of bleeding. |
| Apixaban | SEVERE | Apixaban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of developi... |
| Argatroban | SEVERE | Argatroban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Asparaginase | SEVERE | Asparaginase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of deve... |
| Aspirin | SEVERE | Both Venlafaxine and Aspirin can increase the risk of bleeding. |
| Avapritinib | SEVERE | Venlafaxine might increase the risk of bleeding when given with Avapritinib. Manufacturer advises... |
| Axitinib | SEVERE | Both Venlafaxine and Axitinib can increase the risk of bleeding. |
| Bemiparin | SEVERE | Bemiparin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develop... |
| Benzydamine | SEVERE | Both Venlafaxine and Benzydamine can increase the risk of bleeding. |
| Bevacizumab | SEVERE | Venlafaxine causes bleeding, as can Bevacizumab ; concurrent use might increase the risk of devel... |
| Bivalirudin | SEVERE | Bivalirudin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of devel... |
| Bosutinib | SEVERE | Both Venlafaxine and Bosutinib can increase the risk of bleeding. |
| Bromfenac | SEVERE | Both Venlafaxine and Bromfenac can increase the risk of bleeding. |
| Bupropion | SEVERE | Bupropion might enhance the risk of serotonin syndrome when given with Venlafaxine. MHRA advises ... |
| Cabozantinib | SEVERE | Venlafaxine causes bleeding, as can Cabozantinib ; concurrent use might increase the risk of deve... |
| Cangrelor | SEVERE | Both Venlafaxine and Cangrelor can increase the risk of bleeding. |
| Caplacizumab | SEVERE | Venlafaxine causes bleeding, as can Caplacizumab ; concurrent use might increase the risk of deve... |
| Celecoxib | SEVERE | Both Venlafaxine and Celecoxib can increase the risk of bleeding. |
| Cilostazol | SEVERE | Both Venlafaxine and Cilostazol can increase the risk of bleeding. |
| Citalopram | SEVERE | Both Venlafaxine and Citalopram can increase the risk of bleeding. |
| Clopidogrel | SEVERE | Both Venlafaxine and Clopidogrel can increase the risk of bleeding. |
| Cobimetinib | SEVERE | Venlafaxine causes bleeding, as can Cobimetinib ; concurrent use might increase the risk of devel... |
| Crisantaspase | SEVERE | Crisantaspase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of dev... |
| Dabigatran | SEVERE | Dabigatran causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Dalteparin | SEVERE | Dalteparin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Danaparoid | SEVERE | Danaparoid causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Dapoxetine | SEVERE | Both Venlafaxine and Dapoxetine can increase the risk of bleeding. |
| Dasatinib | SEVERE | Both Venlafaxine and Dasatinib can increase the risk of bleeding. |
| Dexketoprofen | SEVERE | Both Venlafaxine and Dexketoprofen can increase the risk of bleeding. |
| Diclofenac | SEVERE | Both Venlafaxine and Diclofenac can increase the risk of bleeding. |
| Dipyridamole | SEVERE | Both Venlafaxine and Dipyridamole can increase the risk of bleeding. |
| Donanemab | SEVERE | Donanemab can increase the risk of bleeding when given with Venlafaxine. Manufacturer makes no re... |
| Edoxaban | SEVERE | Edoxaban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of developi... |
| Enoxaparin | SEVERE | Enoxaparin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Epoprostenol | SEVERE | Both Venlafaxine and Epoprostenol can increase the risk of bleeding. |
| Eptifibatide | SEVERE | Eptifibatide causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of deve... |
| Escitalopram | SEVERE | Both Venlafaxine and Escitalopram can increase the risk of bleeding. |
| Etodolac | SEVERE | Both Venlafaxine and Etodolac can increase the risk of bleeding. |
| Etoricoxib | SEVERE | Both Venlafaxine and Etoricoxib can increase the risk of bleeding. |
| Fluoxetine | SEVERE | Both Venlafaxine and Fluoxetine can increase the risk of bleeding. |
| Flurbiprofen | SEVERE | Both Venlafaxine and Flurbiprofen can increase the risk of bleeding. |
| Fluvoxamine | SEVERE | Both Venlafaxine and Fluvoxamine can increase the risk of bleeding. |
| Fondaparinux | SEVERE | Fondaparinux causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of deve... |
| Haloperidol | SEVERE | Venlafaxine slightly increases the exposure to Haloperidol. Manufacturer makes no recommendation. |
| Heparin | SEVERE | Heparin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of developin... |
| Ibrutinib | SEVERE | Both Venlafaxine and Ibrutinib can increase the risk of bleeding. |
| Ibuprofen | SEVERE | Both Venlafaxine and Ibuprofen can increase the risk of bleeding. |
| Icosapent | SEVERE | Both Venlafaxine and Icosapent can increase the risk of bleeding. |
| Iloprost | SEVERE | Both Venlafaxine and Iloprost can increase the risk of bleeding. |
| Imatinib | SEVERE | Both Venlafaxine and Imatinib can increase the risk of bleeding. |
| Indometacin | SEVERE | Both Venlafaxine and Indometacin can increase the risk of bleeding. |
| Inotersen | SEVERE | Venlafaxine causes bleeding, as can Inotersen ; concurrent use might increase the risk of develop... |
| Ketoprofen | SEVERE | Both Venlafaxine and Ketoprofen can increase the risk of bleeding. |
| Ketorolac | SEVERE | Both Venlafaxine and Ketorolac can increase the risk of bleeding. |
| Lecanemab | SEVERE | Lecanemab can increase the risk of bleeding when given with Venlafaxine. Manufacturer makes no re... |
| Lenvatinib | SEVERE | Both Venlafaxine and Lenvatinib can increase the risk of bleeding. |
| Mefenamic acid | SEVERE | Both Venlafaxine and Mefenamic acid can increase the risk of bleeding. |
| Meloxicam | SEVERE | Both Venlafaxine and Meloxicam can increase the risk of bleeding. |
| Nabumetone | SEVERE | Both Venlafaxine and Nabumetone can increase the risk of bleeding. |
| Naproxen | SEVERE | Both Venlafaxine and Naproxen can increase the risk of bleeding. |
| Nicotinic acid | SEVERE | Nicotinic acid causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of de... |
| Nintedanib | SEVERE | Both Venlafaxine and Nintedanib can increase the risk of bleeding. |
| Omega-3-acid ethyl esters | SEVERE | Both Venlafaxine and Omega-3-acid ethyl esters can increase the risk of bleeding. |
| Parecoxib | SEVERE | Both Venlafaxine and Parecoxib can increase the risk of bleeding. |
| Paroxetine | SEVERE | Both Venlafaxine and Paroxetine can increase the risk of bleeding. |
| Pazopanib | SEVERE | Both Venlafaxine and Pazopanib can increase the risk of bleeding. |
| Pegaspargase | SEVERE | Pegaspargase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of deve... |
| Pentosan | SEVERE | Pentosan causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of developi... |
| Phenazone | SEVERE | Both Venlafaxine and Phenazone can increase the risk of bleeding. |
| Phenindione | SEVERE | Phenindione causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of devel... |
| Piroxicam | SEVERE | Both Venlafaxine and Piroxicam can increase the risk of bleeding. |
| Ponatinib | SEVERE | Both Venlafaxine and Ponatinib can increase the risk of bleeding. |
| Prasugrel | SEVERE | Both Venlafaxine and Prasugrel can increase the risk of bleeding. |
| Ranibizumab | SEVERE | Venlafaxine causes bleeding, as can Ranibizumab ; concurrent use might increase the risk of devel... |
| Regorafenib | SEVERE | Both Venlafaxine and Regorafenib can increase the risk of bleeding. |
| Rivaroxaban | SEVERE | Rivaroxaban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of devel... |
| Ruxolitinib | SEVERE | Venlafaxine causes bleeding, as can Ruxolitinib ; concurrent use might increase the risk of devel... |
| Sertraline | SEVERE | Both Venlafaxine and Sertraline can increase the risk of bleeding. |
| Sorafenib | SEVERE | Both Venlafaxine and Sorafenib can increase the risk of bleeding. |
| Streptokinase | SEVERE | Streptokinase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of dev... |
| Sulindac | SEVERE | Both Venlafaxine and Sulindac can increase the risk of bleeding. |
| Sunitinib | SEVERE | Both Venlafaxine and Sunitinib can increase the risk of bleeding. |
| Tacrolimus | SEVERE | Tacrolimus potentially increases the risk of serotonin syndrome when given with Venlafaxine. Manu... |
| Tapentadol | SEVERE | Tapentadol is predicted to increase the risk of serotonin syndrome when given with Venlafaxine. M... |
| Tenecteplase | SEVERE | Tenecteplase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of deve... |
| Tenoxicam | SEVERE | Both Venlafaxine and Tenoxicam can increase the risk of bleeding. |
| Tiaprofenic acid | SEVERE | Both Venlafaxine and Tiaprofenic acid can increase the risk of bleeding. |
| Ticagrelor | SEVERE | Both Venlafaxine and Ticagrelor can increase the risk of bleeding. |
| Tinzaparin | SEVERE | Tinzaparin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develo... |
| Tirofiban | SEVERE | Tirofiban causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develop... |
| Tolfenamic acid | SEVERE | Both Venlafaxine and Tolfenamic acid can increase the risk of bleeding. |
| Trametinib | SEVERE | Venlafaxine causes bleeding, as can Trametinib ; concurrent use might increase the risk of develo... |
| Trastuzumab emtansine | SEVERE | Venlafaxine causes bleeding, as can Trastuzumab emtansine ; concurrent use might increase the ris... |
| Treprostinil | SEVERE | Both Venlafaxine and Treprostinil can increase the risk of bleeding. |
| Urokinase | SEVERE | Urokinase causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of develop... |
| Volanesorsen | SEVERE | Venlafaxine causes bleeding, as can Volanesorsen ; concurrent use might increase the risk of deve... |
| Vortioxetine | SEVERE | Both Venlafaxine and Vortioxetine can increase the risk of bleeding. |
| Warfarin | SEVERE | Warfarin causes bleeding, as can Venlafaxine ; concurrent use might increase the risk of developi... |
| Zanubrutinib | SEVERE | Both Venlafaxine and Zanubrutinib can increase the risk of bleeding. |
| Atazanavir | MODERATE | Atazanavir is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Ceritinib | MODERATE | Ceritinib is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Clarithromycin | MODERATE | Clarithromycin is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Cobicistat | MODERATE | Cobicistat is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Darunavir | MODERATE | Darunavir is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Fosamprenavir | MODERATE | Fosamprenavir is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Idelalisib | MODERATE | Idelalisib is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Itraconazole | MODERATE | Itraconazole is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Ketoconazole | MODERATE | Ketoconazole is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Lopinavir | MODERATE | Lopinavir is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Posaconazole | MODERATE | Posaconazole is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Ritonavir | MODERATE | Ritonavir is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Tucatinib | MODERATE | Tucatinib is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Voriconazole | MODERATE | Voriconazole is predicted to increase the exposure to Venlafaxine. Manufacturer advises caution. |
| Cimetidine | MILD | Cimetidine slightly increases the exposure to Venlafaxine. Manufacturer makes no recommendation. |
| Pitolisant | MILD | Venlafaxine is predicted to increase the exposure to Pitolisant. Manufacturer advises use with ca... |
| Agomelatine | LOW | Both Venlafaxine and Agomelatine have effects on the CNS and can cause sedation, which might affe... |
| Alcohol | LOW | Both Venlafaxine and Alcohol have effects on the CNS and can cause sedation, which might affect t... |
| Alfentanil | LOW | Both Venlafaxine and Alfentanil have effects on the CNS and can cause sedation, which might affec... |
| Alimemazine | LOW | Both Venlafaxine and Alimemazine have effects on the CNS and can cause sedation, which might affe... |
| Almotriptan | LOW | Both Venlafaxine and Almotriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Alprazolam | LOW | Both Venlafaxine and Alprazolam have effects on the CNS and can cause sedation, which might affec... |
| Amiloride | LOW | Both Venlafaxine and Amiloride can increase the risk of hyponatraemia. |
| Amisulpride | LOW | Both Venlafaxine and Amisulpride can increase the risk of hyponatraemia. |
| Amitriptyline | LOW | Both Venlafaxine and Amitriptyline can increase the risk of hyponatraemia. |
| Apomorphine | LOW | Both Venlafaxine and Apomorphine have effects on the CNS and can cause sedation, which might affe... |
| Apraclonidine | LOW | Both Venlafaxine and Apraclonidine have effects on the CNS and can cause sedation, which might af... |
| Aripiprazole | LOW | Both Venlafaxine and Aripiprazole can increase the risk of hyponatraemia. |
| Asenapine | LOW | Both Venlafaxine and Asenapine can increase the risk of hyponatraemia. |
| Baclofen | LOW | Both Venlafaxine and Baclofen have effects on the CNS and can cause sedation, which might affect ... |
| Bendroflumethiazide | LOW | Both Venlafaxine and Bendroflumethiazide can increase the risk of hyponatraemia. |
| Benperidol | LOW | Both Venlafaxine and Benperidol can increase the risk of hyponatraemia. |
| Brimonidine | LOW | Both Venlafaxine and Brimonidine have effects on the CNS and can cause sedation, which might affe... |
| Bromocriptine | LOW | Both Venlafaxine and Bromocriptine have effects on the CNS and can cause sedation, which might af... |
| Buclizine | LOW | Both Venlafaxine and Buclizine have effects on the CNS and can cause sedation, which might affect... |
| Bumetanide | LOW | Both Venlafaxine and Bumetanide can increase the risk of hyponatraemia. |
| Buprenorphine | LOW | Both Venlafaxine and Buprenorphine have effects on the CNS and can cause sedation, which might af... |
| Cabergoline | LOW | Both Venlafaxine and Cabergoline have effects on the CNS and can cause sedation, which might affe... |
| Cannabidiol | LOW | Both Venlafaxine and Cannabidiol have effects on the CNS and can cause sedation, which might affe... |
| Carbamazepine | LOW | Both Venlafaxine and Carbamazepine can increase the risk of hyponatraemia. |
| Carboplatin | LOW | Both Venlafaxine and Carboplatin can increase the risk of hyponatraemia. |
| Cariprazine | LOW | Both Venlafaxine and Cariprazine can increase the risk of hyponatraemia. |
| Cenobamate | LOW | Both Venlafaxine and Cenobamate have effects on the CNS and can cause sedation, which might affec... |
| Chloral hydrate | LOW | Both Venlafaxine and Chloral hydrate have effects on the CNS and can cause sedation, which might ... |
| Chlordiazepoxide | LOW | Both Venlafaxine and Chlordiazepoxide have effects on the CNS and can cause sedation, which might... |
| Chlorothiazide | LOW | Both Venlafaxine and Chlorothiazide can increase the risk of hyponatraemia. |
| Chlorphenamine | LOW | Both Venlafaxine and Chlorphenamine have effects on the CNS and can cause sedation, which might a... |
| Chlorpromazine | LOW | Both Venlafaxine and Chlorpromazine can increase the risk of hyponatraemia. |
| Chlortalidone | LOW | Both Venlafaxine and Chlortalidone can increase the risk of hyponatraemia. |
| Cinnarizine | LOW | Both Venlafaxine and Cinnarizine have effects on the CNS and can cause sedation, which might affe... |
| Cisplatin | LOW | Both Venlafaxine and Cisplatin can increase the risk of hyponatraemia. |
| Clobazam | LOW | Both Venlafaxine and Clobazam have effects on the CNS and can cause sedation, which might affect ... |
| Clomethiazole | LOW | Both Venlafaxine and Clomethiazole have effects on the CNS and can cause sedation, which might af... |
| Clomipramine | LOW | Both Venlafaxine and Clomipramine can increase the risk of hyponatraemia. |
| Clonazepam | LOW | Both Venlafaxine and Clonazepam have effects on the CNS and can cause sedation, which might affec... |
| Clonidine | LOW | Both Venlafaxine and Clonidine have effects on the CNS and can cause sedation, which might affect... |
| Clozapine | LOW | Both Venlafaxine and Clozapine can increase the risk of hyponatraemia. |
| Codeine | LOW | Both Venlafaxine and Codeine have effects on the CNS and can cause sedation, which might affect t... |
| Cyclizine | LOW | Both Venlafaxine and Cyclizine have effects on the CNS and can cause sedation, which might affect... |
| Cyclophosphamide | LOW | Both Venlafaxine and Cyclophosphamide can increase the risk of hyponatraemia. |
| Cyproheptadine | LOW | Both Venlafaxine and Cyproheptadine have effects on the CNS and can cause sedation, which might a... |
| Daridorexant | LOW | Both Venlafaxine and Daridorexant have effects on the CNS and can cause sedation, which might aff... |
| Desflurane | LOW | Both Venlafaxine and Desflurane have effects on the CNS and can cause sedation, which might affec... |
| Desmopressin | LOW | Both Venlafaxine and Desmopressin can increase the risk of hyponatraemia. |
| Dexamfetamine | LOW | Both Venlafaxine and Dexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin sy... |
| Dexmedetomidine | LOW | Both Venlafaxine and Dexmedetomidine have effects on the CNS and can cause sedation, which might ... |
| Diamorphine | LOW | Both Venlafaxine and Diamorphine have effects on the CNS and can cause sedation, which might affe... |
| Diazepam | LOW | Both Venlafaxine and Diazepam have effects on the CNS and can cause sedation, which might affect ... |
| Difelikefalin | LOW | Both Venlafaxine and Difelikefalin have effects on the CNS and can cause sedation, which might af... |
| Dihydrocodeine | LOW | Both Venlafaxine and Dihydrocodeine have effects on the CNS and can cause sedation, which might a... |
| Dimenhydrinate | LOW | Both Venlafaxine and Dimenhydrinate have effects on the CNS and can cause sedation, which might a... |
| Dipipanone | LOW | Both Venlafaxine and Dipipanone have effects on the CNS and can cause sedation, which might affec... |
| Dosulepin | LOW | Both Venlafaxine and Dosulepin can increase the risk of hyponatraemia. |
| Doxepin | LOW | Both Venlafaxine and Doxepin can increase the risk of hyponatraemia. |
| Doxylamine | LOW | Both Venlafaxine and Doxylamine have effects on the CNS and can cause sedation, which might affec... |
| Dronabinol | LOW | Both Venlafaxine and Dronabinol have effects on the CNS and can cause sedation, which might affec... |
| Droperidol | LOW | Both Venlafaxine and Droperidol can increase the risk of hyponatraemia. |
| Eletriptan | LOW | Both Venlafaxine and Eletriptan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Esketamine | LOW | Both Venlafaxine and Esketamine have effects on the CNS and can cause sedation, which might affec... |
| Eslicarbazepine | LOW | Both Venlafaxine and Eslicarbazepine can increase the risk of hyponatraemia. |
| Eszopiclone | LOW | Both Venlafaxine and Eszopiclone have effects on the CNS and can cause sedation, which might affe... |
| Etomidate | LOW | Both Venlafaxine and Etomidate have effects on the CNS and can cause sedation, which might affect... |
| Fenfluramine | LOW | Both Venlafaxine and Fenfluramine can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Fentanyl | LOW | Both Venlafaxine and Fentanyl can increase the risk of serotonin syndrome. See 'Serotonin syndrom... |
| Flupentixol | LOW | Both Venlafaxine and Flupentixol can increase the risk of hyponatraemia. |
| Flurazepam | LOW | Both Venlafaxine and Flurazepam have effects on the CNS and can cause sedation, which might affec... |
| Foslevodopa | LOW | Both Venlafaxine and Foslevodopa have effects on the CNS and can cause sedation, which might affe... |
| Fosphenytoin | LOW | Both Venlafaxine and Fosphenytoin have effects on the CNS and can cause sedation, which might aff... |
| Frovatriptan | LOW | Both Venlafaxine and Frovatriptan can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Furosemide | LOW | Both Venlafaxine and Furosemide can increase the risk of hyponatraemia. |
| Gabapentin | LOW | Both Venlafaxine and Gabapentin have effects on the CNS and can cause sedation, which might affec... |
| Granisetron | LOW | Both Venlafaxine and Granisetron can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Guanfacine | LOW | Both Venlafaxine and Guanfacine have effects on the CNS and can cause sedation, which might affec... |
| Hydrochlorothiazide | LOW | Both Venlafaxine and Hydrochlorothiazide can increase the risk of hyponatraemia. |
| Hydroflumethiazide | LOW | Both Venlafaxine and Hydroflumethiazide can increase the risk of hyponatraemia. |
| Hydromorphone | LOW | Both Venlafaxine and Hydromorphone have effects on the CNS and can cause sedation, which might af... |
| Hydroxyzine | LOW | Both Venlafaxine and Hydroxyzine have effects on the CNS and can cause sedation, which might affe... |
| Imipramine | LOW | Both Venlafaxine and Imipramine can increase the risk of hyponatraemia. |
| Indapamide | LOW | Both Venlafaxine and Indapamide can increase the risk of hyponatraemia. |
| Isocarboxazid | LOW | Both Venlafaxine and Isocarboxazid can increase the risk of serotonin syndrome. See 'Serotonin sy... |
| Isoflurane | LOW | Both Venlafaxine and Isoflurane have effects on the CNS and can cause sedation, which might affec... |
| Ketamine | LOW | Both Venlafaxine and Ketamine have effects on the CNS and can cause sedation, which might affect ... |
| Ketotifen | LOW | Both Venlafaxine and Ketotifen have effects on the CNS and can cause sedation, which might affect... |
| Lamotrigine | LOW | Both Venlafaxine and Lamotrigine have effects on the CNS and can cause sedation, which might affe... |
| Levetiracetam | LOW | Both Venlafaxine and Levetiracetam have effects on the CNS and can cause sedation, which might af... |
| Levodopa | LOW | Both Venlafaxine and Levodopa have effects on the CNS and can cause sedation, which might affect ... |
| Levomepromazine | LOW | Both Venlafaxine and Levomepromazine can increase the risk of hyponatraemia. |
| Linezolid | LOW | Both Venlafaxine and Linezolid can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Lisdexamfetamine | LOW | Both Venlafaxine and Lisdexamfetamine can increase the risk of serotonin syndrome. See 'Serotonin... |
| Lithium | LOW | Both Venlafaxine and Lithium can increase the risk of serotonin syndrome. See 'Serotonin syndrome... |
| Lofepramine | LOW | Both Venlafaxine and Lofepramine can increase the risk of hyponatraemia. |
| Lofexidine | LOW | Both Venlafaxine and Lofexidine have effects on the CNS and can cause sedation, which might affec... |
| Loprazolam | LOW | Both Venlafaxine and Loprazolam have effects on the CNS and can cause sedation, which might affec... |
| Lorazepam | LOW | Both Venlafaxine and Lorazepam have effects on the CNS and can cause sedation, which might affect... |
| Lormetazepam | LOW | Both Venlafaxine and Lormetazepam have effects on the CNS and can cause sedation, which might aff... |
| Loxapine | LOW | Both Venlafaxine and Loxapine can increase the risk of hyponatraemia. |
| Lurasidone | LOW | Both Venlafaxine and Lurasidone can increase the risk of hyponatraemia. |
| Mannitol | LOW | Both Venlafaxine and Mannitol can increase the risk of hyponatraemia. |
| Melatonin | LOW | Both Venlafaxine and Melatonin have effects on the CNS and can cause sedation, which might affect... |
| Meptazinol | LOW | Both Venlafaxine and Meptazinol have effects on the CNS and can cause sedation, which might affec... |
| Methadone | LOW | Both Venlafaxine and Methadone can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Methocarbamol | LOW | Both Venlafaxine and Methocarbamol have effects on the CNS and can cause sedation, which might af... |
| Methoxyflurane | LOW | Both Venlafaxine and Methoxyflurane have effects on the CNS and can cause sedation, which might a... |
| Methylthioninium chloride | LOW | Both Venlafaxine and Methylthioninium chloride can increase the risk of serotonin syndrome. See '... |
| Metolazone | LOW | Both Venlafaxine and Metolazone can increase the risk of hyponatraemia. |
| Mianserin | LOW | Both Venlafaxine and Mianserin have effects on the CNS and can cause sedation, which might affect... |
| Midazolam | LOW | Both Venlafaxine and Midazolam have effects on the CNS and can cause sedation, which might affect... |
| Mirtazapine | LOW | Both Venlafaxine and Mirtazapine can increase the risk of hyponatraemia. |
| Moclobemide | LOW | Both Venlafaxine and Moclobemide can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Morphine | LOW | Both Venlafaxine and Morphine have effects on the CNS and can cause sedation, which might affect ... |
| Moxonidine | LOW | Both Venlafaxine and Moxonidine have effects on the CNS and can cause sedation, which might affec... |
| Nabilone | LOW | Both Venlafaxine and Nabilone have effects on the CNS and can cause sedation, which might affect ... |
| Naratriptan | LOW | Both Venlafaxine and Naratriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Nitrazepam | LOW | Both Venlafaxine and Nitrazepam have effects on the CNS and can cause sedation, which might affec... |
| Nitrous oxide | LOW | Both Venlafaxine and Nitrous oxide have effects on the CNS and can cause sedation, which might af... |
| Nortriptyline | LOW | Both Venlafaxine and Nortriptyline can increase the risk of hyponatraemia. |
| Olanzapine | LOW | Both Venlafaxine and Olanzapine can increase the risk of hyponatraemia. |
| Ondansetron | LOW | Both Venlafaxine and Ondansetron can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Orphenadrine | LOW | Both Venlafaxine and Orphenadrine have effects on the CNS and can cause sedation, which might aff... |
| Oxazepam | LOW | Both Venlafaxine and Oxazepam have effects on the CNS and can cause sedation, which might affect ... |
| Oxcarbazepine | LOW | Both Venlafaxine and Oxcarbazepine can increase the risk of hyponatraemia. |
| Oxycodone | LOW | Both Venlafaxine and Oxycodone have effects on the CNS and can cause sedation, which might affect... |
| Oxytocin | LOW | Both Venlafaxine and Oxytocin can increase the risk of hyponatraemia. |
| Paliperidone | LOW | Both Venlafaxine and Paliperidone can increase the risk of hyponatraemia. |
| Palonosetron | LOW | Both Venlafaxine and Palonosetron can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Pentazocine | LOW | Both Venlafaxine and Pentazocine can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Perampanel | LOW | Both Venlafaxine and Perampanel have effects on the CNS and can cause sedation, which might affec... |
| Pericyazine | LOW | Both Venlafaxine and Pericyazine can increase the risk of hyponatraemia. |
| Pethidine | LOW | Both Venlafaxine and Pethidine can increase the risk of serotonin syndrome. See 'Serotonin syndro... |
| Phenelzine | LOW | Both Venlafaxine and Phenelzine can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Phenobarbital | LOW | Both Venlafaxine and Phenobarbital have effects on the CNS and can cause sedation, which might af... |
| Phenytoin | LOW | Both Venlafaxine and Phenytoin have effects on the CNS and can cause sedation, which might affect... |
| Pimozide | LOW | Both Venlafaxine and Pimozide can increase the risk of hyponatraemia. |
| Pizotifen | LOW | Both Venlafaxine and Pizotifen have effects on the CNS and can cause sedation, which might affect... |
| Pramipexole | LOW | Both Venlafaxine and Pramipexole have effects on the CNS and can cause sedation, which might affe... |
| Pregabalin | LOW | Both Venlafaxine and Pregabalin have effects on the CNS and can cause sedation, which might affec... |
| Primidone | LOW | Both Venlafaxine and Primidone have effects on the CNS and can cause sedation, which might affect... |
| Prochlorperazine | LOW | Both Venlafaxine and Prochlorperazine can increase the risk of hyponatraemia. |
| Procyclidine | LOW | Both Venlafaxine and Procyclidine have effects on the CNS and can cause sedation, which might aff... |
| Promazine | LOW | Both Venlafaxine and Promazine can increase the risk of hyponatraemia. |
| Promethazine | LOW | Both Venlafaxine and Promethazine have effects on the CNS and can cause sedation, which might aff... |
| Propofol | LOW | Both Venlafaxine and Propofol have effects on the CNS and can cause sedation, which might affect ... |
| Quetiapine | LOW | Both Venlafaxine and Quetiapine can increase the risk of hyponatraemia. |
| Quinagolide | LOW | Both Venlafaxine and Quinagolide have effects on the CNS and can cause sedation, which might affe... |
| Rasagiline | LOW | Both Venlafaxine and Rasagiline can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Remifentanil | LOW | Both Venlafaxine and Remifentanil have effects on the CNS and can cause sedation, which might aff... |
| Remimazolam | LOW | Both Venlafaxine and Remimazolam have effects on the CNS and can cause sedation, which might affe... |
| Risperidone | LOW | Both Venlafaxine and Risperidone can increase the risk of hyponatraemia. |
| Rizatriptan | LOW | Both Venlafaxine and Rizatriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Ropinirole | LOW | Both Venlafaxine and Ropinirole have effects on the CNS and can cause sedation, which might affec... |
| Rotigotine | LOW | Both Venlafaxine and Rotigotine have effects on the CNS and can cause sedation, which might affec... |
| Rufinamide | LOW | Both Venlafaxine and Rufinamide have effects on the CNS and can cause sedation, which might affec... |
| Safinamide | LOW | Both Venlafaxine and Safinamide can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Selegiline | LOW | Both Venlafaxine and Selegiline can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Sevoflurane | LOW | Both Venlafaxine and Sevoflurane have effects on the CNS and can cause sedation, which might affe... |
| Sodium oxybate | LOW | Both Venlafaxine and Sodium oxybate have effects on the CNS and can cause sedation, which might a... |
| St John's wort | LOW | Both Venlafaxine and St John's wort can increase the risk of serotonin syndrome. See 'Serotonin s... |
| Sufentanil | LOW | Both Venlafaxine and Sufentanil have effects on the CNS and can cause sedation, which might affec... |
| Sulpiride | LOW | Both Venlafaxine and Sulpiride can increase the risk of hyponatraemia. |
| Sumatriptan | LOW | Both Venlafaxine and Sumatriptan can increase the risk of serotonin syndrome. See 'Serotonin synd... |
| Temazepam | LOW | Both Venlafaxine and Temazepam have effects on the CNS and can cause sedation, which might affect... |
| Tetrabenazine | LOW | Both Venlafaxine and Tetrabenazine have effects on the CNS and can cause sedation, which might af... |
| Thalidomide | LOW | Both Venlafaxine and Thalidomide have effects on the CNS and can cause sedation, which might affe... |
| Thiopental | LOW | Both Venlafaxine and Thiopental have effects on the CNS and can cause sedation, which might affec... |
| Tizanidine | LOW | Both Venlafaxine and Tizanidine have effects on the CNS and can cause sedation, which might affec... |
| Torasemide | LOW | Both Venlafaxine and Torasemide can increase the risk of hyponatraemia. |
| Tramadol | LOW | Both Venlafaxine and Tramadol can increase the risk of hyponatraemia. |
| Tranylcypromine | LOW | Both Venlafaxine and Tranylcypromine can increase the risk of serotonin syndrome. See 'Serotonin ... |
| Trazodone | LOW | Both Venlafaxine and Trazodone can increase the risk of hyponatraemia. |
| Trifluoperazine | LOW | Both Venlafaxine and Trifluoperazine can increase the risk of hyponatraemia. |
| Trihexyphenidyl | LOW | Both Venlafaxine and Trihexyphenidyl have effects on the CNS and can cause sedation, which might ... |
| Trimipramine | LOW | Both Venlafaxine and Trimipramine can increase the risk of hyponatraemia. |
| Tryptophan | LOW | Both Venlafaxine and Tryptophan can increase the risk of serotonin syndrome. See 'Serotonin syndr... |
| Valproate | LOW | Both Venlafaxine and Valproate can increase the risk of hyponatraemia. |
| Vigabatrin | LOW | Both Venlafaxine and Vigabatrin have effects on the CNS and can cause sedation, which might affec... |
| Vinblastine | LOW | Both Venlafaxine and Vinblastine can increase the risk of hyponatraemia. |
| Vincristine | LOW | Both Venlafaxine and Vincristine can increase the risk of hyponatraemia. |
| Vinorelbine | LOW | Both Venlafaxine and Vinorelbine can increase the risk of hyponatraemia. |
| Xipamide | LOW | Both Venlafaxine and Xipamide can increase the risk of hyponatraemia. |
| Zolmitriptan | LOW | Both Venlafaxine and Zolmitriptan can increase the risk of serotonin syndrome. See 'Serotonin syn... |
| Zolpidem | LOW | Both Venlafaxine and Zolpidem have effects on the CNS and can cause sedation, which might affect ... |
| Zopiclone | LOW | Both Venlafaxine and Zopiclone have effects on the CNS and can cause sedation, which might affect... |
| Zuclopenthixol | LOW | Both Venlafaxine and Zuclopenthixol can increase the risk of hyponatraemia. |
| Vaborbactam | UNKNOWN | Vaborbactam is predicted to increase the concentration of Venlafaxine. Manufacturer advises monit... |
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