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SEVERE

Clarithromycin and Ivacaftor Interaction

Clarithromycin is predicted to increase the exposure to Ivacaftor. Manufacturer advises adjust dose with potent CYP3A4 inhibitors, see ivacaftor, lumacaftor with ivacaftor, tezacaftor with ivacaftor, and ivacaftor with tezacaftor and elexacaftor.

Evidence: Study
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