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SEVERE

Clarithromycin and Tezacaftor Interaction

Clarithromycin is predicted to increase the exposure to Tezacaftor. Manufacturer advises adjust dose with potent CYP3A4 inhibitors, see tezacaftor with ivacaftor, ivacaftor with tezacaftor and elexacaftor, and deutivacaftor with tezacaftor and vanzacaftor.

Evidence: Study
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